Formation of Hydroxycarbonate Apatite Layer on Poly(Lactic Acid) Composites in Simulated Body Fluid

2005 ◽  
Vol 284-286 ◽  
pp. 489-492 ◽  
Author(s):  
Hirotaka Maeda ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
Keyword(s):  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Zeta Potential ◽  
Calcium Chloride ◽  
Composite Membrane ◽  
Body Fluid ◽  
Poly Lactic Acid ◽  
Zeta Potentials ◽  
Carbonate Ion ◽  
Ft Ir

Hydroxycarbonate apatite (HCA), which formed on a poly(lactic acid) (PLA) composite membrane containing vaterite or calcium chloride after soaking in simulated body fluid, was examined to clarify the importance of the ceramic phases in the composites. FT-IR spectra showed that the ratio of CO3/PO4 in the infrared adsorption bands of HCA formed on the PLA composite containing vaterite was much larger than that of HCA formed on the PLA composite containing calcium chloride. Substitution of carbonate ion in hydroxyapatite is believed to be strongly influenced by ceramic phases in the composites. The zeta potentials of HCA formed on the PLA composite containing vaterite or calcium chloride was -6 mV or -17 mV, respectively. The zeta potential may be influenced by the amount of carbonate ion in hydroxyapatite.

Preparation of Silicon-Containing Poly(lactic acid)-Vaterite Hybrid Membranes

2010 ◽  
Vol 638-642 ◽  
pp. 670-674
Author(s):  
Akiko Obata ◽  
Takashi Wakita ◽  
Yoshio Ota ◽  
Toshihiro Kasuga
Keyword(s):  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Bone Regeneration ◽  
Trace Amount ◽  
Body Fluid ◽  
Poly Lactic Acid ◽  
Osteogenic Cells ◽  
A Cell ◽  
Silicon Doped ◽  
Gbr Membrane

Microfiber meshes releasing a trace amount of silicon species were prepared by electrospinning silicon-doped vaterite (SiV) and poly(lactic acid) (PLA) hybrids for application to membranes for guided bone regeneration (GBR). A trace amount of silicon-species has been reported to enhance the mineralization and bone-forming abilities of osteogenic cells. The microfiber meshes prepared by electrospinning are regarded to be a useful candidate for the GBR membrane, because they have adequate flexibility and porosity for it. In this study, hydroxyapatite (HA)-forming abilities in simulated body fluid, silicon-releasabilities, compatibility with osteoblast-like cells of the prepared microfiber meshes were examined. The meshes were completely coated with HA after soaking in simulated body fluid for 1 day. The meshes coated with HA released 0.2 -0.7 mg/L of silicon species in a cell culture medium for 7 days. The cells elongated on the microfibers of the meshes and some of them entered the mesh after 1 day-culturing. The meshes are expected to provide an excellent substrate for bone regeneration and enhance bone-forming ability of the cells.

Fabrication of Hydroxyapatite Microcapsules by Biomimetic Method

2007 ◽  
Vol 330-332 ◽  
pp. 1029-1032 ◽  
Author(s):  
Yasuhiro Tabe ◽  
Mitsuhiro Hibino ◽  
Takeshi Yao
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Body Fluid ◽  
Poly Lactic Acid ◽  
Biomimetic Method

Apatite nuclei were synthesized by raising pH of simulated body fluid (SBF). Poly (lactic acid) (PLA) microspheres were soaked in apatite nuclei suspension, and then apatite nuclei were attached to surfaces of the PLA microspheres. When these PLA microspheres were soaked in SBF, apatite nuclei on the PLA microspheres induced HAp. As a result, PLA microspheres coated with HAp were fabricated. The HAp-coated PLA microspheres were soaked in acetone. The PLA core was dissolved out, and then consequently hollow microcapsules constructed of HAp were fabricated. As HAp microcapsules have properties of bioaffinity and non-toxicity, they were expected to be applicable to an excellent carrier of drug delivery system.

scholarly journals Effect of Alkaline–hydrolyzed Bioactive Poly（Lactic Acid-ε-caprolactone）Film on Apatite Precipitation in Simulated Body Fluid

2021 ◽  
Vol 20 (1) ◽  
pp. 11-18
Author(s):  
Megumi Fuse ◽  
Tomomi Hashizume - Takizawa ◽  
Chieko Taguchi ◽  
Kou Fujita - Nakajima ◽  
Takao Kuwada - Kusunose
Keyword(s):  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Poly Lactic Acid

scholarly journals Preparations of Poly(lactic acid) Dispersions in Water for Coating Applications

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2767
Author(s):  
Giada Belletti ◽  
Sara Buoso ◽  
Lucia Ricci ◽  
Alejandro Guillem-Ortiz ◽  
Alejandro Aragón-Gutiérrez ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Gel Permeation Chromatography ◽  
Sem Analysis ◽  
Water Phase ◽  
Poly Lactic Acid ◽  
Water Emulsion ◽  
Preparation Conditions ◽  
Ft Ir ◽  
Homogenization Methods ◽  
Oil In Water Emulsion

A green, effective methodology for the preparation of water-based dispersions of poly(lactic acid) (PLA) for coating purposes is herein presented. The procedure consists of two steps: in the first one, an oil-in-water emulsion is obtained by mixing a solution of PLA in ethyl acetate with a water phase containing surfactant and stabilizer. Different homogenization methods as well as oil/water phase ratio, surfactant and stabilizer combinations were screened. In the second step, the quantitative evaporation of the organic provides water dispersions of PLA that are stable, at least, over several weeks at room temperature or at 4 °C. Particle size was in the 200–500 nm range, depending on the preparation conditions, as confirmed by scanning electron microscope (SEM) analysis. PLA was found not to suffer significant molecular weight degradation by gel permeation chromatography (GPC) analysis. Furthermore, two selected formulations with glass transition temperature (Tg) of 51 °C and 34 °C were tested for the preparation of PLA films by drying in PTFE capsules. In both cases, continuous films that are homogeneous by Fourier-transform infrared spectroscopy (FT-IR) and SEM observation were obtained only when drying was performed above 60 °C. The formulation with lower Tg results in films which are more flexible and transparent.

Preparation and characterization of a novel hydroxyapatite-wollastonite/silk fibroin composite

2011 ◽  
Vol 46 (13) ◽  
pp. 1571-1581 ◽  
Author(s):  
Song Zhao ◽  
Zhufa Zhou ◽  
Jiang Wu ◽  
Shumei Wang ◽  
Xinshuang Guo ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Low Temperature ◽  
Simulated Body Fluid ◽  
Silk Fibroin ◽  
Body Fluid ◽  
Bone Repair ◽  
Coprecipitation Method ◽  
Ft Ir ◽  
Low Crystallinity

A novel hydroxyapatite-wollastonite/silk fibroin (AW/SF) composite was prepared for bone repair and replacement by a modified coprecipitation method. The wollastonite powders introduced in the composite were sintered with full crytallinity and ground to the diameter of 30–50 nm. The FT-IR and XRD analyses showed that the silk fibroin, wollastonite, and hydroxyapatite co-existed in the composite, but the newly formed hydroxyapatite had low crystallinity ascribing to the low temperature procedure. The composite exhibited both higher compressive strength (84.4 MPa) and Barcol hardness (48.5) than the hydroxyapatite/silk fibroin (HA/SF) composite without any wallostonite involved. And the composite in this work showed excellent bioactivities while held in simulated body fluid (SBF).

Characterization of Electrospun Poly(Lactic Acid)/polyaniline Blend Nanofibers

2011 ◽  
Vol 332-334 ◽  
pp. 317-320 ◽  
Author(s):  
Hui Qin Zhang
Keyword(s):  
Lactic Acid ◽  
Composite Nanofibers ◽  
Weight Ratio ◽  
Electrospinning Process ◽  
Poly Lactic Acid ◽  
X Ray Diffraction ◽  
Sem Images ◽  
X Ray ◽  
Ft Ir

In this study, composite nanofibers of polyaniline doped with dodecylbenzene sulfonic acid (PANI-DBSA) and Poly(lactic acid) (PLA) were prepared via an electrospinning process. The surface morphology, thermal properties and crystal structure of PLA/PANI-DBSA nanofibers are characterized using Fourier transform infrared spectroscopy (FT-IR), wide-angle x-ray diffraction (WAXD) and scanning electron microscopy (SEM). SEM images showed that the morphology and diameter of the nanofibers were affected by the weight ratio of blend solution.

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