scholarly journals Effect of Alkaline–hydrolyzed Bioactive Poly（Lactic Acid-ε-caprolactone）Film on Apatite Precipitation in Simulated Body Fluid

2021 ◽  
Vol 20 (1) ◽  
pp. 11-18
Author(s):  
Megumi Fuse ◽  
Tomomi Hashizume - Takizawa ◽  
Chieko Taguchi ◽  
Kou Fujita - Nakajima ◽  
Takao Kuwada - Kusunose
Keyword(s):  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Poly Lactic Acid

Formation of Hydroxycarbonate Apatite Layer on Poly(Lactic Acid) Composites in Simulated Body Fluid

2005 ◽  
Vol 284-286 ◽  
pp. 489-492 ◽  
Author(s):  
Hirotaka Maeda ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
Keyword(s):  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Zeta Potential ◽  
Calcium Chloride ◽  
Composite Membrane ◽  
Body Fluid ◽  
Poly Lactic Acid ◽  
Zeta Potentials ◽  
Carbonate Ion ◽  
Ft Ir

Hydroxycarbonate apatite (HCA), which formed on a poly(lactic acid) (PLA) composite membrane containing vaterite or calcium chloride after soaking in simulated body fluid, was examined to clarify the importance of the ceramic phases in the composites. FT-IR spectra showed that the ratio of CO3/PO4 in the infrared adsorption bands of HCA formed on the PLA composite containing vaterite was much larger than that of HCA formed on the PLA composite containing calcium chloride. Substitution of carbonate ion in hydroxyapatite is believed to be strongly influenced by ceramic phases in the composites. The zeta potentials of HCA formed on the PLA composite containing vaterite or calcium chloride was -6 mV or -17 mV, respectively. The zeta potential may be influenced by the amount of carbonate ion in hydroxyapatite.

Preparation of Silicon-Containing Poly(lactic acid)-Vaterite Hybrid Membranes

2010 ◽  
Vol 638-642 ◽  
pp. 670-674
Author(s):  
Akiko Obata ◽  
Takashi Wakita ◽  
Yoshio Ota ◽  
Toshihiro Kasuga
Keyword(s):  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Bone Regeneration ◽  
Trace Amount ◽  
Body Fluid ◽  
Poly Lactic Acid ◽  
Osteogenic Cells ◽  
A Cell ◽  
Silicon Doped ◽  
Gbr Membrane

Microfiber meshes releasing a trace amount of silicon species were prepared by electrospinning silicon-doped vaterite (SiV) and poly(lactic acid) (PLA) hybrids for application to membranes for guided bone regeneration (GBR). A trace amount of silicon-species has been reported to enhance the mineralization and bone-forming abilities of osteogenic cells. The microfiber meshes prepared by electrospinning are regarded to be a useful candidate for the GBR membrane, because they have adequate flexibility and porosity for it. In this study, hydroxyapatite (HA)-forming abilities in simulated body fluid, silicon-releasabilities, compatibility with osteoblast-like cells of the prepared microfiber meshes were examined. The meshes were completely coated with HA after soaking in simulated body fluid for 1 day. The meshes coated with HA released 0.2 -0.7 mg/L of silicon species in a cell culture medium for 7 days. The cells elongated on the microfibers of the meshes and some of them entered the mesh after 1 day-culturing. The meshes are expected to provide an excellent substrate for bone regeneration and enhance bone-forming ability of the cells.

Fabrication of Hydroxyapatite Microcapsules by Biomimetic Method

2007 ◽  
Vol 330-332 ◽  
pp. 1029-1032 ◽  
Author(s):  
Yasuhiro Tabe ◽  
Mitsuhiro Hibino ◽  
Takeshi Yao
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Body Fluid ◽  
Poly Lactic Acid ◽  
Biomimetic Method

Apatite nuclei were synthesized by raising pH of simulated body fluid (SBF). Poly (lactic acid) (PLA) microspheres were soaked in apatite nuclei suspension, and then apatite nuclei were attached to surfaces of the PLA microspheres. When these PLA microspheres were soaked in SBF, apatite nuclei on the PLA microspheres induced HAp. As a result, PLA microspheres coated with HAp were fabricated. The HAp-coated PLA microspheres were soaked in acetone. The PLA core was dissolved out, and then consequently hollow microcapsules constructed of HAp were fabricated. As HAp microcapsules have properties of bioaffinity and non-toxicity, they were expected to be applicable to an excellent carrier of drug delivery system.

Biodegradable Mg Strengthened Poly-Lactic Acid Composite through Interfacial Properties

2017 ◽  
Vol 900 ◽  
pp. 7-11
Author(s):  
Muhammad Shoaib Butt ◽  
Jing Bai ◽  
Feng Xue
Keyword(s):  
Lactic Acid ◽  
Body Fluid ◽  
Biomedical Applications ◽  
Mechanical Performance ◽  
High Strength ◽  
Poly Lactic Acid ◽  
Magnesium Alloy Az31 ◽  
Injection Process ◽  
Good Potential ◽  
Plastic Injection

High-strength magnesium alloy (AZ31) reinforced poly-lactic acid (PLA) composite rods for potential application of bone fracture fixation prepared by plastic injection process on Mg rod.Thecomposities possess improved the interfacial bonding between poly-lactic acid and Mg rod due to the micro-anchoring which lead to better mechanical performance in Simulated body fluid solution.The present results indicated that this new PLA-clad Mg composite rods show good potential for biomedical applications.

Biomineralization of electrospun poly(l-lactic acid)/gelatin composite fibrous scaffold by using a supersaturated simulated body fluid with continuous CO2 bubbling

2011 ◽  
Vol 257 (23) ◽  
pp. 10109-10118 ◽  
Author(s):  
Qing Cai ◽  
Qingqing Xu ◽  
Qiaofang Feng ◽  
Xiaoyan Cao ◽  
Xiaoping Yang ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Fibrous Scaffold
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