Physical Properties of Composite Membrane Containing Apatite and Poly-Lactic Acid /Poly-Glycolic Acid Copolymer In Vitro

2005 ◽  
pp. 749-752
Author(s):  
T. Watanabe ◽  
Seiji Ban ◽  
Toshiki Itoh ◽  
Shozo Tsuruta ◽  
Takahiro Kawai ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Physical Properties ◽  
Composite Membrane ◽  
Glycolic Acid ◽  
Poly Lactic Acid ◽  
Acid Copolymer

Physical Properties of Composite Membrane Containing Apatite and Poly-Lactic Acid /Poly-Glycolic Acid Copolymer In Vitro

2005 ◽  
Vol 284-286 ◽  
pp. 749-752
Author(s):  
T. Watanabe ◽  
Seiji Ban ◽  
Toshiki Itoh ◽  
Shozo Tsuruta ◽  
Takahiro Kawai ◽  
...  
Keyword(s):  
Physical Properties ◽  
Composite Membrane ◽  
Body Fluid ◽  
Glycolic Acid ◽  
Poly Lactic Acid ◽  
X Ray ◽  
Acid Copolymer ◽  
Before And After

The purpose of this study was to evaluate the physical properties of the composite membrane before and after soaking in simulated body fluid (SBF) and discuss both degradation and maintenance of their properties. Before and after soaking in SBF, some deposits were found on the preexisted apatite crystals, and Ca and P were mainly detected by energy dispersive X-ray analyzer (EDX). Our results suggest that the composite membrane consisting of apatite and the biodegradable PLGA copolymer would have excellent biocompatibility and maintain adequate physical properties for in vivo use.

scholarly journals DEGRADASI POLIBLEND POLI(ASAMLAKTAT-KO-ASAMGLIKOLAT) DENGAN POLI(ε-KAPROLAKTON) SECARA IN VITRO

2015 ◽  
Vol 2 (2) ◽  
pp. 174
Author(s):  
Tetty Kemala ◽  
Achmad Sjahriza ◽  
Hendra Adijuwana ◽  
Mardiana Hardianti
Keyword(s):  
Lactic Acid ◽  
Polylactic Acid ◽  
Intrinsic Viscosity ◽  
Phosphate Buffer ◽  
Glycolic Acid ◽  
Incubation Temperature ◽  
Human Life ◽  
Polyglycolic Acid ◽  
Poly Lactic Acid

 ABSTRACT  Polymer has many applications in human life, one of them is in the field of health. Polymer synthetics like polylactic acid (PLA), polyglycolic acid (PGA), poly(ε-caprolactone) (PCL), and poly(lactic acid-co-glycolic acid) (PLGA) were kind of polyesters that is many used in field   of health. Many researchers have already made research about degradation of PLA, PGA, PCL, and PLGA. However, there is no one doing research about degradation of combination between this two polymers, one of them is polyblend of  PLGA and PCL. Polyblend were made of four compositions, that were PLGA(90:10):PCL 3:1, PLGA(75:25):PCL 3:1, PLGA(90:10):PCL 5:1, and PLGA(75:25):PCL 5:1. Degradation was carried out for eight weeks by using phosphate buffer pH 7.4 and incubation temperature of 37°C. Degradation of the polymer was observed by mass remained, and intrinsic viscosity. The result showed that composition PLGA(75:25):PCL 5:1 was the fastest in degradation compared to other compositions. It was showed by the decrease in mass until 89.06% and the change in intrinsic viscosity until 20.13%. Keywords: PLGA, PCL   

A Knitted Scaffold for Tendon Engineering Using Poly (Lactic Acid) Fibers

2011 ◽  
Vol 197-198 ◽  
pp. 164-167 ◽  
Author(s):  
Zheng Guo ◽  
Jin Jing Chen ◽  
Pei Hua Zhang
Keyword(s):  
Tensile Strength ◽  
Lactic Acid ◽  
Glycolic Acid ◽  
Cell Attachment ◽  
Dermal Fibroblasts ◽  
Poly Lactic Acid ◽  
Better Than

A tubal knitted scaffold fabricated from poly(lactic acid) (PLA) yarns was given in this work. The performance of the scaffold during degradation in vitro and the morphology of the scaffold with cells (monkey dermal fibroblasts) were examined. The scaffold fabricated from poly(glycolic acid) (PGA) yarns was manufactured as the control. Results showed that the PLA scaffold could keep much more tensile strength during degradation in vitro, compared with the PGA scaffold. However, cell attachment and proliferation on the PGA scaffold were better than on the PLA scaffold.

Alternative methods of sterilization on films of polymers: Poly(-L-lactic acid) (PLLA), Poly(L-lactic acid-co-glycolic acid) (PLGA) and Poly(-LD-lactic acid) (PLDLA), for bioresorbable vascular scaffolds models

2018 ◽  
pp. 248-256 ◽  
Author(s):  
Adriana Del Monaco ◽  
ER Duek ◽  
Aron José Pazin de Andrade ◽  
SM Malmonge
Keyword(s):  
Lactic Acid ◽  
Glycolic Acid ◽  
Alternative Methods ◽  
Poly Lactic Acid ◽  
Differential Scanning Calorimetric ◽  
Calorimetric Analysis ◽  
Acid Copolymer ◽  
Vascular Scaffolds ◽  
Living Organisms ◽  
The Stability

Biodegradable polymers have been the subject of study for more than three decades because of their unique characteristics such as: biocompatibility and non-immunogenic and non-toxic properties, revealing their great acceptance in living organisms and being used as fastening elements in materials such as prostheses, sutures, drug encapsulation matrices and several important applications. The Poly(-lactic acid) (PLLA and PLDLA) and its glycolic acid copolymer (PLGA), present great biocompatibility. A problem when using polymers in bioengineering is sterilization process, which should enable the inactivation of a wide variety of microorganisms without affecting the properties of the materials of the device sterilized. Most of the processes used have limitations for use in thermo sensitive and chemo sensitive materials. Among the alternatives are ultraviolet radiation (UV) and plasma of hydrogen peroxide. This project tested these two alternatives methods, in films and tubes of these polymers. After the process of sterilization, no changes were found in thermal properties evaluated by differential scanning calorimetric analysis (DSC) and termogravimetric analysis (TGA). The mechanical properties of the PLLA, PLDLA and PLGA materials after the sterilization processes, also presents no changes, by UV and plasma, indicating the stability of samples to these processes.

scholarly journals A Tailored Thermosensitive PLGA-PEG-PLGA/Emulsomes Composite for Enhanced Oxcarbazepine Brain Delivery via the Nasal Route

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 217 ◽  
Author(s):  
Ghada El-Zaafarany ◽  
Mahmoud Soliman ◽  
Samar Mansour ◽  
Marco Cespi ◽  
Giovanni Palmieri ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Glycolic Acid ◽  
Histopathological Examination ◽  
Nasal Administration ◽  
Poly Lactic Acid ◽  
Saline Control ◽  
Pharmacokinetic Studies ◽  
Sustained Drug Release

The use of nanocarrier delivery systems for direct nose to brain drug delivery shows promise for achieving increased brain drug levels as compared to simple solution systems. An example of such nanocarriers is emulsomes formed from lipid cores surrounded and stabilised by a corona of phospholipids (PC) and a coating of Tween 80, which combines the properties of both liposomes and emulsions. Oxcarbazepine (OX), an antiepileptic drug, was entrapped in emulsomes and then localized in a poly(lactic acid-co-glycolic acid)-poly(ethylene glycol)-poly(lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) triblock copolymer thermogel. The incorporation of OX emulsomes in thermogels retarded drug release and increased its residence time (MRT) in rats. The OX-emulsome and the OX-emulsome-thermogel formulations showed in vitro sustained drug release of 81.1 and 53.5%, respectively, over a period of 24 h. The pharmacokinetic studies in rats showed transport of OX to the systemic circulation after nasal administration with a higher uptake in the brain tissue in case of OX-emulsomes and highest MRT for OX-emulsomal-thermogels as compared to the IN OX-emulsomes, OX-solution and Trileptal® suspension. Histopathological examination of nasal tissues showed a mild vascular congestion and moderate inflammatory changes around congested vessels compared to saline control, but lower toxic effect than that reported in case of the drug solution.

scholarly journals Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid)

Biomaterials ◽  
2008 ◽  
Vol 29 (3) ◽  
pp. 337-349 ◽  
Author(s):  
Meng Deng ◽  
Lakshmi S. Nair ◽  
Syam P. Nukavarapu ◽  
Sangamesh G. Kumbar ◽  
Tao Jiang ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Glycolic Acid ◽  
Poly Lactic Acid ◽  
Biodegradable Blends
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