Enhance of Tumor Targeting by Receptor-Mediated Endocytosis Using Low Molecular Water-Soluble Chitosan Nanoparticles Loaded with Anticancer Agent
2007 ◽
Vol 342-343
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pp. 469-472
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Keyword(s):
In this study, we prepared using low molecular weight water-soluble chitosan nanoparticle loaded paclitaxel (LMWSC-NPT) and investigated the potential as a drug carrier which is able to accumulate in the tumor site. In the experiment of receptor-mediated endocytosis, LMWSC-NPT was treated with sodium azid (NaN3) as an inhibitor of endocytosis process. As results, the antitumor activity of LMWSC-NPT treated with sodium azid didn’t show but LMWSC-NPT was shown the high antitumor activity. Therefore, LMWSC-NPs modified with hydrophobic group will be useful anticancer agent carrier via receptor-mediated endocytosis.
2007 ◽
pp. 469-472
2006 ◽
Vol 319
(1-2)
◽
pp. 130-138
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2003 ◽
Vol 11
(20)
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pp. 4303-4313
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Keyword(s):
2009 ◽
Vol 27
(15_suppl)
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pp. 2570-2570
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2013 ◽
Vol 796
◽
pp. 92-97
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Keyword(s):