PL DLLA Calcium Phosphate Composite Combined with Macroporous Calcium Phosphate Cement MCPC® for New Surgical Technologies Combining Resorbable Osteosynthesis and Injectable Bone Substitute

Resorbable osteosynthesis based on PLLA and derivatives will be associated to bone substitute for bone reconstruction. We have performed rand evaluated a composite combining PL DLLA and Biphasic calcium phosphate able to have a), a better controlled hydrolysis in the purpose to preserve on time the mechanical property, and b), for long term efficiency, bone ingrowth at the expense of the osteosynthesis and the associated bone substitute. A new calcium phosphate cement MCPC® was tested with such composite. The novel macroporous calcium phosphate cement MCPC sets to poorly crystalline apatite after mixing the powder component and an aqueous solution. Interconnective macroporosity was induced on time by resorption of one part of the MCPC®. The multiphasic calcium phosphate components in the cement, are resorbed at different rates allowing the replacement by newly formed bone. This study reports the biocompatibility and the interactions of a composite using PL DLLA (Poly [L-Lactide-co-D,L-Lactide] acid) charged with biphasic calcium phosphate granules and a self setting calcium phosphate cement of new generation.

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Macroporous Calcium Phosphate Cement (MCPC®) for Bone Reconstruction in Cranioplasty: Animal Study Performance

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.396-398.245 ◽

2008 ◽

Vol 396-398 ◽

pp. 245-248

Author(s):

Xavier Bourges ◽

Eric Aguado ◽

Eric Goyenvalle ◽

Serge Baroth ◽

G. Daculsi

Keyword(s):

Mechanical Properties ◽

Calcium Phosphate ◽

Calcium Phosphate Cement ◽

Bone Ingrowth ◽

Parietal Bone ◽

Cement Matrix ◽

Bone Reconstruction ◽

Reconstruction Surgery ◽

Powder Component ◽

Study Performance

We have developed a novel macroporous calcium phosphate cement MCPC® that sets to poorly crystalline apatite after mixing the powder component with an aqueous solution and has interconnective macroporosity We performed cranioplasty on rat model by injecting the new macroporous calcium phosphate cement MCPC®. The mechanical property of the cement is about 12MPa after 24 hours (compression test). The cement matrix is totally transformed into poorly crystalline apatite in 48 hours. This study demonstrates that MCPC® cement was suitable and efficient for parietal bone reconstruction. Its injectability and moldability allows to be used in bone reconstruction surgery and its mechanical properties are compatible to support calvarial reconstruction. In addition, a bone ingrowth onto the BCP granules occurred on time.

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Performance for Bone Ingrowth of Biphasic Calcium Phosphate Ceramic Versus Bovine Bone Substitute

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.309-311.1379 ◽

2006 ◽

Vol 309-311 ◽

pp. 1379-1382 ◽

Cited By ~ 2

Author(s):

G. Daculsi ◽

P. Corre ◽

Oliver Malard ◽

Racquel Z. LeGeros ◽

Eric Goyenvalle

Keyword(s):

Calcium Phosphate ◽

Bone Substitute ◽

Biphasic Calcium Phosphate ◽

Bone Ingrowth ◽

Maxillofacial Surgery ◽

Bovine Bone ◽

Calcium Phosphate Ceramic ◽

Porous Biphasic Calcium Phosphate

Calcium phosphate bioceramics and bovine bone xenograft with or without sintering are more or less used in orthopaedics or in maxillofacial surgery. In this study we compare in a rat femoral epiphysis model after 3 weeks of implantation the bone in growth at the expense of granules of same size of micro macro porous biphasic calcium phosphate MBCP, sintered bovine bone and unsintered BioOss.

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Performance for Bone Ingrowth of Biphasic Calcium Phosphate Ceramic Versus Bovine Bone Substitute

Bioceramics 18 - Key Engineering Materials ◽

10.4028/0-87849-992-x.1379 ◽

2006 ◽

pp. 1379-1382

Author(s):

Guy Daculsi ◽

P. Corre ◽

Oliver Malard ◽

Racquel Z. LeGeros ◽

Eric Goyenvalle

Keyword(s):

Calcium Phosphate ◽

Bone Substitute ◽

Biphasic Calcium Phosphate ◽

Bone Ingrowth ◽

Bovine Bone ◽

Calcium Phosphate Ceramic

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Biphasic calcium phosphate as a bone substitute

Frontiers in Bioengineering and Biotechnology ◽

10.3389/conf.fbioe.2016.01.00487 ◽

2016 ◽

Vol 4 ◽

Author(s):

Pluta Klaudia ◽

Walczyk Dorota ◽

Sobczak-Kupiec Agnieszka ◽

Malina Dagmara ◽

Tyliszczak Bozena

Keyword(s):

Calcium Phosphate ◽

Bone Substitute ◽

Biphasic Calcium Phosphate

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The pH-Dependent Properties of the Biphasic Calcium Phosphate for Bone Cements

Journal of Biomimetics Biomaterials and Biomedical Engineering ◽

10.4028/www.scientific.net/jbbbe.21.3 ◽

2014 ◽

Vol 21 ◽

pp. 3-16 ◽

Cited By ~ 5

Author(s):

Nuan La Ong Srakaew ◽

Sirirat Tubsungnoen Rattanachan

Keyword(s):

Compressive Strength ◽

Liquid Phase ◽

Calcium Phosphate ◽

Phase Analysis ◽

Calcium Phosphate Cement ◽

Biphasic Calcium Phosphate ◽

Setting Time ◽

Bone Cements ◽

Apatite Formation ◽

Apatite Cement

Self-setting calcium phosphate cement (CPC) has been used in bone repair and substitution due to their excellent biocompatibility, bioactive as well as simplicity of preparation and use. The inherent brittleness and slow degradation are the major disadvantages for the use of calcium phosphate cements. To improve the degradation for the traditional CPC, the apatite cement formula incorporated with β-tricalcium phosphate (β-TCP) with varying concentration were studied and the effect of the pH value of liquid phase on the properties of this new calcium phosphate cement formula was evaluated. The apatite cements containing β-TCP for 10 and 40 wt.% were mixed into the aqueous solution with different pH values and then aging in absolute humidity at 37°C for 7 days. The setting time and phase analysis of the biphasic calcium phosphate were determined as compared to the apatite cement. For proper medical application, the compressive strength, the phase analysis and the degradation of the CPC samples at pH 7.0 and 7.4 were evaluated after soaking in the simulated body fluid (SBF) at 37°C for 7 days. The results indicated that the properties of the samples such as the setting time, the compressive strength related to the phase analysis of the set cements. The high degradation of the CPC was found in the cement with increasing β-TCP addition due to the phase after setting. Apatite formation with oriented plate-like morphology was also found to be denser on the surface of the biphasic bone cements after soaking in SBF for 7 days. The obtained results indicated that the cement containing β-TCP mixed with the liquid phase at pH 7.4 could be considered as a highly biodegradable and bioactive bone cement, as compared to the traditional CPC.

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Vertebroplasty in Goat Model Using Macroporous Calcium Phosphate Cement (MCPC®)

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.361-363.377 ◽

2007 ◽

Vol 361-363 ◽

pp. 377-380

Author(s):

Xavier Bourges ◽

Serge Baroth ◽

Eric Goyenvalle ◽

Ronan Cognet ◽

Françoise Moreau ◽

...

Keyword(s):

Mechanical Properties ◽

Mechanical Property ◽

Calcium Phosphate ◽

Compression Test ◽

Invasive Surgery ◽

Calcium Phosphate Cement ◽

Bone Ingrowth ◽

Cement Matrix

We performed vertebroplasty on goat model by injecting a new macroporous calcium phosphate cement MCPC®. The mechanical property of the cement is about 12MPa after 24 hours (compression test). The cement matrix is totally transformed into poorly crystallized apatite in 48 hours. This study demonstrates that MCPC cement was suitable and efficient for a spine application. Its injectability allows to be used in mini invasive surgery and its mechanical properties are compatible to support spine strength. In addition, a bone ingrowth onto the BCP granules occurred with time.

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Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.361-363.119 ◽

2007 ◽

Vol 361-363 ◽

pp. 119-122 ◽

Cited By ~ 4

Author(s):

J.H. Lim ◽

J.H. Park ◽

Eui Kyun Park ◽

Hae Jung Kim ◽

Il Kyu Park ◽

...

Keyword(s):

Tissue Engineering ◽

Calcium Phosphate ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Bone Substitute ◽

Biphasic Calcium Phosphate ◽

Bone Defects ◽

Calcium Phosphate Ceramic ◽

Ceramic Scaffold ◽

Porous Biphasic Calcium Phosphate

An appropriate scaffold, which provides structural support for transplanted cells and acts as a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. We developed a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold by adopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bone tissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacity in rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnecting interpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity and noxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffold construct formation. Also the bone defects grafted with fully interconnected globular porous biphasic calcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findings suggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by the foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.

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Macro/Microporous Biphasic Calcium Phosphate Cylinders and Resorbable Collagen Membranes for Guided Bone Growth

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.361-363.439 ◽

2007 ◽

Vol 361-363 ◽

pp. 439-442

Author(s):

Borhane H. Fellah ◽

Said Kimakhe ◽

G. Daculsi ◽

Pierre Layrolle

Keyword(s):

Calcium Phosphate ◽

Biphasic Calcium Phosphate ◽

Bone Growth ◽

Bone Ingrowth ◽

Collagen Membrane ◽

Calcium Phosphate Ceramic ◽

Collagen Membranes ◽

Large Bone ◽

Empty Control ◽

Large Bone Defects

This study aims at evaluating bone growth in critical-sized femoral defects of rats filled with macro micro porous biphasic calcium phosphate ceramic (MBCP) cylinders surrounded or not by a resorbable collagen membrane. Femoral defects left empty (control) exhibited partial bone ingrowths after 3 and 6 weeks and were completely healed at 12 weeks. The defects filled with the collagen membranes appeared partially healed suggesting that the membranes constraint bone ingrowth. Bone formation occurred around the collagen membrane which partially degraded over time. In the MBCP/membrane group, bone has grown inside the macro pores of the MBCP cylinders. Bone ingrowth was more rapid and abundant in the defects filled with MBCP alone. The combination MBCP/collagen membrane may be beneficial for the reconstruction of large bone defects without using repetitive surgeries and autologous bone grafting.

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