Macroporous Calcium Phosphate Cement (MCPC®) for Bone Reconstruction in Cranioplasty: Animal Study Performance

2008 ◽  
Vol 396-398 ◽  
pp. 245-248
Author(s):  
Xavier Bourges ◽  
Eric Aguado ◽  
Eric Goyenvalle ◽  
Serge Baroth ◽  
G. Daculsi
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Bone Ingrowth ◽  
Parietal Bone ◽  
Cement Matrix ◽  
Bone Reconstruction ◽  
Reconstruction Surgery ◽  
Powder Component ◽  
Study Performance

We have developed a novel macroporous calcium phosphate cement MCPC® that sets to poorly crystalline apatite after mixing the powder component with an aqueous solution and has interconnective macroporosity We performed cranioplasty on rat model by injecting the new macroporous calcium phosphate cement MCPC®. The mechanical property of the cement is about 12MPa after 24 hours (compression test). The cement matrix is totally transformed into poorly crystalline apatite in 48 hours. This study demonstrates that MCPC® cement was suitable and efficient for parietal bone reconstruction. Its injectability and moldability allows to be used in bone reconstruction surgery and its mechanical properties are compatible to support calvarial reconstruction. In addition, a bone ingrowth onto the BCP granules occurred on time.

Vertebroplasty in Goat Model Using Macroporous Calcium Phosphate Cement (MCPC®)

2007 ◽  
Vol 361-363 ◽  
pp. 377-380
Author(s):  
Xavier Bourges ◽  
Serge Baroth ◽  
Eric Goyenvalle ◽  
Ronan Cognet ◽  
Françoise Moreau ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Mechanical Property ◽  
Calcium Phosphate ◽  
Compression Test ◽  
Invasive Surgery ◽  
Calcium Phosphate Cement ◽  
Bone Ingrowth ◽  
Cement Matrix

We performed vertebroplasty on goat model by injecting a new macroporous calcium phosphate cement MCPC®. The mechanical property of the cement is about 12MPa after 24 hours (compression test). The cement matrix is totally transformed into poorly crystallized apatite in 48 hours. This study demonstrates that MCPC cement was suitable and efficient for a spine application. Its injectability allows to be used in mini invasive surgery and its mechanical properties are compatible to support spine strength. In addition, a bone ingrowth onto the BCP granules occurred with time.

PL DLLA Calcium Phosphate Composite Combined with Macroporous Calcium Phosphate Cement MCPC® for New Surgical Technologies Combining Resorbable Osteosynthesis and Injectable Bone Substitute

2007 ◽  
Vol 361-363 ◽  
pp. 411-414 ◽  
Author(s):  
Gaelle Jouan ◽  
Eric Goyenvalle ◽  
Eric Aguado ◽  
Ronan Cognet ◽  
Françoise Moreau ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Bone Ingrowth ◽  
The Novel ◽  
Powder Component ◽  
New Generation ◽  
Controlled Hydrolysis

Resorbable osteosynthesis based on PLLA and derivatives will be associated to bone substitute for bone reconstruction. We have performed rand evaluated a composite combining PL DLLA and Biphasic calcium phosphate able to have a), a better controlled hydrolysis in the purpose to preserve on time the mechanical property, and b), for long term efficiency, bone ingrowth at the expense of the osteosynthesis and the associated bone substitute. A new calcium phosphate cement MCPC® was tested with such composite. The novel macroporous calcium phosphate cement MCPC sets to poorly crystalline apatite after mixing the powder component and an aqueous solution. Interconnective macroporosity was induced on time by resorption of one part of the MCPC®. The multiphasic calcium phosphate components in the cement, are resorbed at different rates allowing the replacement by newly formed bone. This study reports the biocompatibility and the interactions of a composite using PL DLLA (Poly [L-Lactide-co-D,L-Lactide] acid) charged with biphasic calcium phosphate granules and a self setting calcium phosphate cement of new generation.

The Effect of Cefazolin on Mechanical Properties and Antibacterial Reactions of Calcium Phosphate Cement

2011 ◽  
Vol 46 (4) ◽  
pp. 273
Author(s):  
Ki-Dae Kwon ◽  
Jae-Suk Chang ◽  
Soo-Ho Lee ◽  
Dong-Ho Lee ◽  
Kang-Sik Lee ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Calcium Phosphate Cement

Effect of Methotrexate on the Mechanical Properties and Microstructure of Calcium Phosphate Cement

Orthopedics ◽  
2014 ◽  
Vol 37 (10) ◽  
pp. e906-e910 ◽  
Author(s):  
Guangjun Liao ◽  
Dongxiu Sun ◽  
Jian Han ◽  
Jiangwei Tan
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Calcium Phosphate Cement

Stearate Salts as Brushite Bone Cement Setting Retardants

2005 ◽  
Vol 284-286 ◽  
pp. 19-22 ◽  
Author(s):  
M.P. Hofmann ◽  
Uwe Gbureck ◽  
Liam M. Grover ◽  
J.E. Barralet
Keyword(s):  
Compressive Strength ◽  
Calcium Phosphate ◽  
Bone Cement ◽  
Calcium Phosphate Cement ◽  
Tricalcium Phosphate ◽  
Sodium Stearate ◽  
Setting Times ◽  
Powder Component ◽  
Cement System ◽  
Cement Setting

This study sought to examine the efficiency of coating cement powder reactants in order to reduce the solubility rate of reactants and thereby increase setting times of cement systems. In this investigation magnesium and sodium stearate salts were used to coat the highly soluble monocalcium phosphate monohydrate (MCPM) powder component of a hydraulic brushite forming calcium phosphate cement system with b-tricalcium phosphate (b-TCP) as other component. The results showed that stearate coating of the MCPM reactant could lead to a 100% increase in setting and working times without affecting compressive strength of the set cement when applied with the appropriate P/L-ratio.

scholarly journals Deposition of Hydroxyapatite on Silica Made from Rice Husk Ash to Produce the Powder Component of Calcium Phosphate Cement

2020 ◽  
Author(s):  
Tri Windarti ◽  
Widjijono Widjijono ◽  
Nuryono Nuryono
Keyword(s):  
Calcium Phosphate ◽  
Rice Husk ◽  
Calcium Phosphate Cement ◽  
Rice Husk Ash ◽  
Sol Gel ◽  
Molar Ratio ◽  
Composite Surface ◽  
Cell Parameters ◽  
Powder Component ◽  
Sio2 Particles

Hydroxyapatite (HA) has been deposited on silica (SiO2) particles to produce HA-SiO2 composite that will be used as the powder component of calcium phosphate cement. HA was expected to be on the composite surface to maintain its bioactivity. SiO2 was made by the sol-gel method, in which silicate solution was extracted from rice husk ash with NaOH solution. Deposition of HA on SiO2 was carried out by wet chemical deposition method at various Ca/Si molar ratio (in a range of 5–25) followed by calcination at 600 °C for 2 h. Results showed that HA was successfully deposited on SiO2 particles. The cell parameters of the HA crystals were slightly distorted by the presence of SiO2 and HA in the composite had a bigger cell volume than pure HA. The crystallite size of HA in the composites increased with the increase of the Ca/Si ratio but the values were smaller than pure HA. SiO2 acted as a morphology directing agent. At low Ca/Si ratio, the HA-SiO2 particles were in a form of short rod-like particles with sizes of < 50 nm, while at high Ca/Si ratio, a mixture of short and long rod-like particles with the size of < 100 nm was obtained. The zeta potential of composites was almost similar to pure HA. These properties indicated that HA-SiO2 composites support the bioactivity of injectable calcium phosphate cement.

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