Drug Adsorption Property of Surfaces of Polarized Calcium Phosphate Powders
Keyword(s):
Calcium phosphate powders (hydroxyapatite, α-tricalcium phosphate, β-tricalcium phosphate, and tetracalcium phosphate) were electrically polarized by an applied dc voltage. Thermally stimulated depolarization current measurements confirmed that each calcium phosphate powder exhibited surface charges after polarization treatment. The surface adsorption of simvastatin on each powder was investigated. We observed a difference in adsorption between polarized and non-polarized powders. This difference in adsorption is due to the electrostatic force between the polarized surface and the open-ring form of simvastatin, which has a larger electrical polarity than its closed-ring form.
2012 ◽
Vol 727-728
◽
pp. 1164-1169
◽
2012 ◽
Vol 8
(11)
◽
pp. 919-924
◽
2012 ◽
Vol 8
(9)
◽
pp. 3500-3508
◽
Keyword(s):
1929 ◽
Vol 51
(4)
◽
pp. 1097-1106
◽
1954 ◽
Vol 21
(2)
◽
pp. 229-237
◽
Keyword(s):
2006 ◽
Vol 309-311
◽
pp. 333-336