The Role of Hyaluronic Acid in the Correction of Soft Tissue Deficiencies: Review and Clinical Considerations

2015 ◽  
Vol 638 ◽  
pp. 270-273
Author(s):  
Andrei Carantino
Keyword(s):  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Soft Tissues ◽  
Years Of Experience ◽  
Clinical Considerations ◽  
Surgical Operations

This paper presents some aspects from last 10 years of experience, when we used the hyaluronic acid produced and traded by a certain company, to obtain aesthetic good results in the treatment of the facial wrinkles, nazolabial folds, augmentation of the lips, face rejuvenation and hydration, correction of soft tissues deficiencies after major surgical operations.

scholarly journals SANOGENETIC AND PHARMACOLOGICAL EFFECTS OF LOCAL APPLICATION OF HYALURONIC ACID IN EXPERIMENTAL SOFT TISSUE COMPRESSION TRAUMA

2020 ◽  
Vol 10 (2) ◽  
pp. 53-60
Author(s):  
I. A. Shperling ◽  
A. V. Shulepov ◽  
N. V. Shperling ◽  
Yu. V. Yurkevich ◽  
O. Yu. Kuzmina ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Soft Tissues ◽  
Local Application ◽  
Control Group ◽  
Repair System ◽  
Pharmacological Effects ◽  
Muscle Injuries ◽  
Compression Injury ◽  
Tissue Compression

Regional activation of cellular repair systems, including local application of hyaluronic acid, is a promising direction for the sanogenesis of muscle injuries. Purpose: to identify the sanogenetic and pharmacological effects of local application of hyaluronic acid in experimental soft tissue compression trauma. Compression injury was simulated by mechanical compression of the right pelvic limb of a rat at the level of the lower leg for 7 hours with a pressure force of 10-12 kg/cm2. Further, the animals were divided into 2 groups: 3 hours after decompression, animals in the main group were injected with 3.5% hyaluronic acid (the drug «Hyalift 3.5») by fan-pricking with a sterile disposable syringe at 5-6 points to a depth of 0.5-0.8 cm in a volume of up to 0.1 ml at each point; rats in the control group were given a similar method and an equivalent volume of 0.9% sodium chloride solution. The level of myoglobin in the blood, microcirculation, histomorphological and immuno- histochemical characteristics of tissues in the compression area were studied. A comprehensive analysis of the results of the study allowed us to establish that early local administration of 3.5% hyaluronic acid to the area of compression damage of soft tissues (3 hours after decompression) has a muscle-protecting effect, activates the repair system of damaged skeletal muscles. It is concluded that the sanogenetic effect of hyaluronic acid is mediated by the mecha- nisms of its pharmacological action: activation of angiogenesis, improvement of in situ efficiency of microcirculation and metabolism, reduction of the severity of primary and secondary necrosis and about traumatic disorders, activation of regeneration of damaged muscle fibers with the formation of muscle tissue. Hyaluronic acid is an active stimulant of reparative processes in the perspective of pharmacotherapy and may be a promising component in the local correction of extensive traumatic injuries.

Processing and Characterization of a Composite of Hyaluronic Acid (HA) and Microspheres Biphasic Calcium Phosphate (BCP) for Dermal Repair

2012 ◽  
Vol 529-530 ◽  
pp. 421-425
Author(s):  
Edirlaine Soares Silva ◽  
Deny Gomes de Freitas ◽  
Sidney Nicodemos da Silva
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Soft Tissue ◽  
Biphasic Calcium Phosphate ◽  
Soft Tissues ◽  
Biological Response ◽  
Water Soluble ◽  
Potential Candidate ◽  
Dermal Fillers

Dermal fillers are injectable implants made of biological materials (collagen, autologous fat and hyaluronic acid animal) or synthetic (PMMA microparticles of hydroxyapatite and non-animal hyaluronic acid), biodegradable or not, that include features such as ideal biocompatibility, durability, non-profile migration and ability to promote a smooth, natural-looking correction. Its main indication is intended to treat contour defects caused by aging, photo damage, disease, trauma or scarification. The fact of biodegradable fillers are absorbed within a year after application resulted in the emergence of products permanent and semi-permanent to offer patients long-lasting effects. Currently, one of the most effective strategies has been the development of scaffolds formed by combining two or more biomaterials seeking the restoration of tissue function. The bioceramic associated with water-soluble polymers have been developed as substitutes for the repair of soft tissues with optimal biological response. The objective of this study was to process and characterize a composite hydrogel in the form of hyaluronic acid (HA) microspheres and biphasic calcium phosphate (BCP) in order injectable applications for repair of soft tissue. The powders of HA and BCP were characterized by Infrared Spectroscopy Fourier Transform (FTIR) and X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM). The characterization of the hydrogel injectability pure and the composite with different ratios of HA and BCP was performed. The components were characterized compatible for use as dermal fillers. The composite of hyaluronic acid (HA) and biphasic calcium phosphate (BCP) had adequate characterization and injetabilidade proving to be a potential candidate for restoration of soft tissue.

The Role of Biology in the Fossilization of Embryos and Other Soft-Bodied Organisms: Microbial Biofilms and Lagerstätten

2014 ◽  
Vol 20 ◽  
pp. 83-100
Author(s):  
Rudolf A. Raff ◽  
Elizabeth C. Raff
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Active Role ◽  
Microbial Interactions ◽  
Skin Texture ◽  
Microbial Biofilms ◽  
Insect Wings ◽  
Large Animals ◽  
Simple Systems

Soft-tissue fossils are among the most striking and informative remains of extinct organisms. Although relatively rare, they are diverse, ranging from single microbial cells to nuclei and chromosomes; algae; metazoan embryos and larvae; flowers; complete, small, soft-bodied metazoans, metazoan tissues; integumentary structures such as melanosomes; skin texture, vertebrate feathers and hair, insect wings with color patterns, and sometimes even the entire bodies of large animals. The susceptibility of newly dead soft tissues to physical destruction, consumption, and microbial decay makes their preservation unlikely under most taphonomic conditions. In addition, their vulnerability to rapid autolysis, bioturbation, and destructive physical processes requires that rapid biological events must occur as the critical first steps of fossilization. An understanding of the processes by which biological remains enter the fossil record is important in inferring what non-microbial and microbial processes were operative in Lagerstätten. Paleontologists have recognized that microbial biofilms often accompany soft-tissue fossils, and have suggested that bacteria play an active role in soft tissue fossilization, but that role must be determined experimentally with living bacteria and dead tissue.Marine embryos and marine bacteria are used to investigate the processes that mediate early steps in soft-tissue preservation because they offer simple systems for laboratory investigation of the roles of autolysis-blocking environments, microbial interactions, biofilm formation, and authigenic mineralization in taphonomy. Understanding microbially mediated preservation of embryos may supply new insights into a more general biology of fossilization.

scholarly journals Principles of Soft Tissue Management in Dental Implants

2017 ◽  
pp. 36-39
Author(s):  
Xiao-Quan Mao
Keyword(s):  
Soft Tissue ◽  
Dental Implants ◽  
Soft Tissues ◽  
Negative Impact ◽  
Final Analysis ◽  
Cochrane Library ◽  
Study Selection ◽  
Tissue Factors ◽  
The Impact

Objective: To evaluate the impact of soft tissue factors in dental implants. Data: Studies evaluating the role of soft tissues in dental implants were included in this review. Sources: A comprehensive literature search of English and Chinese language articles was performed via electronic databases (PubMed, Cochrane Library, Web of Science, CNKI and VIP) using the appropriate key words(esthetic; evaluation; impact factor; soft tissue). The most recent search took place in January 2016. Study selection: Potentially appropriate articles were identified and evaluated for eligibility through a predefined review process conducted by two examiners. Only 16 out of the 346 identified records met criteria and were included in the final analysis. Conclusion: The success of dental implants depends on two outcomes, the functional utility of the implant and its beauty. During the early phase of treatment, the main objective of a dental implant is to achieve adequate function. In clinical practice, however, subsequent soft tissue retraction and implant exposure have a significantly negative impact on implant esthetics, especially in young women’s teeth, which can also be considered as implant failure. It is particularly important to understand how to support the surrounding soft tissue so that it is esthetically pleasing.

scholarly journals Early formation and taphonomic significance of kaolinite associated with Burgess Shale fossils

Geology ◽  
2020 ◽  
Vol 49 (4) ◽  
pp. 355-359
Author(s):  
Ross P. Anderson ◽  
Nicholas J. Tosca ◽  
Erin E. Saupe ◽  
Jon Wade ◽  
Derek E.G. Briggs
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Heterotrophic Bacteria ◽  
Burgess Shale ◽  
X Ray Diffraction ◽  
The Matrix ◽  
Shale Formation ◽  
Area X

Abstract The role of minerals in Burgess Shale–type fossilization is controversial, particularly that of the clay mineral kaolinite. Kaolinite may have formed on carcasses or attached to them as they decayed, stabilizing organic matter. Alternatively, kaolinite may have formed during metamorphism, playing no role in the preservation of soft tissues. Evaluating the formation and taphonomic role of kaolinite is difficult, because the mineralogy of Burgess Shale–type fossils is incompletely known. We used in situ selected-area X-ray diffraction to constrain the mineralogy of fossils from the classic Burgess Shale Formation in British Columbia, Canada. Fossils can be distinguished from the matrix that surrounds them by the presence of dolomite, kaolinite, and pyrite. Chlorite may be more abundant in the matrix. The preferential survival of kaolinite in association with fossils provides evidence of early diagenetic clay-organic interactions that protected the clay from metamorphic transformation. Kaolinite likely played a crucial role in fossilization, inhibiting the growth of heterotrophic bacteria and aiding polymerization of soft tissue biomolecules. This may result in biases in soft-tissue preservation to areas and times where kaolinite was prevalent.

scholarly journals The Role of Cutaneous Microcirculatory Responses in Tissue Injury, Inflammation and Repair at the Foot in Diabetes

2021 ◽  
Vol 9 ◽  
Author(s):  
Gayathri Victoria Balasubramanian ◽  
Nachiappan Chockalingam ◽  
Roozbeh Naemi
Keyword(s):  
Blood Flow ◽  
Soft Tissue ◽  
Diabetic Foot ◽  
Soft Tissues ◽  
Tissue Injury ◽  
Applied Pressure ◽  
Skin Perfusion ◽  
Increased Risk ◽  
Microcirculatory Function

Diabetic foot syndrome is one of the most costly complications of diabetes. Damage to the soft tissue structure is one of the primary causes of diabetic foot ulcers and most of the current literature focuses on factors such as neuropathy and excessive load. Although the role of blood supply has been reported in the context of macro-circulation, soft tissue damage and its healing in the context of skin microcirculation have not been adequately investigated. Previous research suggested that certain microcirculatory responses protect the skin and their impairment may contribute to increased risk for occlusive and ischemic injuries to the foot. The purpose of this narrative review was to explore and establish the possible link between impairment in skin perfusion and the chain of events that leads to ulceration, considering the interaction with other more established ulceration factors. This review highlights some of the key skin microcirculatory functions in response to various stimuli. The microcirculatory responses observed in the form of altered skin blood flow are divided into three categories based on the type of stimuli including occlusion, pressure and temperature. Studies on the three categories were reviewed including: the microcirculatory response to occlusive ischemia or Post-Occlusive Reactive Hyperaemia (PORH); the microcirculatory response to locally applied pressure such as Pressure-Induced Vasodilation (PIV); and the interplay between microcirculation and skin temperature and the microcirculatory responses to thermal stimuli such as reduced/increased blood flow due to cooling/heating. This review highlights how microcirculatory responses protect the skin and the plantar soft tissues and their plausible dysfunction in people with diabetes. Whilst discussing the link between impairment in skin perfusion as a result of altered microcirculatory response, the review describes the chain of events that leads to ulceration. A thorough understanding of the microcirculatory function and its impaired reactive mechanisms is provided, which allows an understanding of the interaction between functional disturbances of microcirculation and other more established factors for foot ulceration.

scholarly journals Impact of Soft Tissue Pathophysiology in the Development and Maintenance of Bisphosphonate Related Osteonecrosis of the Jaw (BRONJ)

2016 ◽  
Author(s):  
Thomas Ziebart ◽  
Sebastian Blatt ◽  
Junho Jung ◽  
Andreas Pabst ◽  
Christian Walter ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Cell Biology ◽  
Soft Tissues ◽  
Mevalonate Pathway ◽  
Osteonecrosis Of The Jaw ◽  
Biological Behavior ◽  
Cell Architecture ◽  
High Concentrations ◽  
Apoptosis And Necrosis

Since the first description of bisphosphonate-related osteonecrosis of the jaw (BRONJ) numerous research groups have focused on possible pathological mechanisms including the suppression of the bone turnover of the jaw, antiangiogenic effects and soft tissue toxicity. In our review we focused on summarizing the role of the soft tissues in the development and progression of BRONJ. The biological behavior of fibroblasts can be significantly influenced by bisphosphonates (BP) such as a concentration dependent reduction of cell viability. High concentrations of BP can induce apoptosis and necrosis of the cells. Comparable effects could be detected for keratinocytes. Compared to non-nitrogen containing bisphosphonates nitrogen-containing BP have worse effects on cell biology by blocking the mevalonate pathway. Next to this the cell architecture and the expression levels of several genes and proteins are significantly disturbed by BP. These inhibitory effects of BP are in accordance with BP related reduced angiogenesis and neovascularization and could underline the hypothesis that inhibition of fibroblasts and keratinocytes results in delayed wound healing and can induce and trigger BRONJ.

Soft Tissue Sarcoma: The Important Role of Initial MRI Reports for Disease Control

2020 ◽  
Author(s):  
S Weiß ◽  
A Korthaus ◽  
K-H Frosch ◽  
C Schlickewei ◽  
M Priemel
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Disease Control
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