The Balance between Bone Formation and Material Resorption in Unidirectional Porous β-Tricalcium Phosphate Implanted in a Rabbit Tibia

2016 ◽  
Vol 696 ◽  
pp. 177-182 ◽  
Author(s):  
Takeshi Makihara ◽  
Masataka Sakane ◽  
Hiroshi Noguchi ◽  
Masashi Yamazaki
Keyword(s):  
Bone Formation ◽  
Bone Defect ◽  
Tricalcium Phosphate ◽  
Histomorphometric Analysis ◽  
Defect Model ◽  
Micropore Structure ◽  
Animal Bone ◽  
Rabbit Tibia

We examined the balance between bone formation and material resorption in β-tricalcium phosphate, with unidirectional pores (porosity of 57%) and micropore structure. Using an animal bone defect model, rapid bone formation reached to the center of the material, while the material remained at the same period. Histomorphometric analysis showed that the sum total area of formed bone and material gradually increased with time throughout the experiment. These results indicate that the balance between bone formation and material resorption in this material is satisfactory.

scholarly journals Physical and Histological Comparison of Hydroxyapatite, Carbonate Apatite, and β-Tricalcium Phosphate Bone Substitutes

Materials ◽  
2018 ◽  
Vol 11 (10) ◽  
pp. 1993 ◽  
Author(s):  
Kunio Ishikawa ◽  
Youji Miyamoto ◽  
Akira Tsuchiya ◽  
Koichiro Hayashi ◽  
Kanji Tsuru ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Defect ◽  
Tricalcium Phosphate ◽  
Bone Substitutes ◽  
Physiological Solution ◽  
Tissue Response ◽  
Histological Evaluation ◽  
Carbonate Apatite ◽  
Artificial Bone ◽  
New Bone Formation

Three commercially available artificial bone substitutes with different compositions, hydroxyapatite (HAp; Neobone®), carbonate apatite (CO3Ap; Cytrans®), and β-tricalcium phosphate (β-TCP; Cerasorb®), were compared with respect to their physical properties and tissue response to bone, using hybrid dogs. Both Neobone® (HAp) and Cerasorb® (β-TCP) were porous, whereas Cytrans® (CO3Ap) was dense. Crystallite size and specific surface area (SSA) of Neobone® (HAp), Cytrans® (CO3Ap), and Cerasorb® (β-TCP) were 75.4 ± 0.9 nm, 30.8 ± 0.8 nm, and 78.5 ± 7.5 nm, and 0.06 m2/g, 18.2 m2/g, and 1.0 m2/g, respectively. These values are consistent with the fact that both Neobone® (HAp) and Cerasorb® (β-TCP) are sintered ceramics, whereas Cytrans® (CO3Ap) is fabricated in aqueous solution. Dissolution in pH 5.3 solution mimicking Howship’s lacunae was fastest in CO3Ap (Cytrans®), whereas dissolution in pH 7.3 physiological solution was fastest in β-TCP (Cerasorb®). These results indicated that CO3Ap is stable under physiological conditions and is resorbed at Howship’s lacunae. Histological evaluation using hybrid dog mandible bone defect model revealed that new bone was formed from existing bone to the center of the bone defect when reconstructed with CO3Ap (Cytrans®) at week 4. The amount of bone increased at week 12, and resorption of the CO3Ap (Cytrans®) was confirmed. β-TCP (Cerasorb®) showed limited bone formation at week 4. However, a larger amount of bone was observed at week 12. Among these three bone substitutes, CO3Ap (Cytrans®) demonstrated the highest level of new bone formation. These results indicate the possibility that bone substitutes with compositions similar to that of bone may have properties similar to those of bone.

scholarly journals Implantation of Tetrapod-Shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model

2014 ◽  
Vol 76 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Sungjin CHOI ◽  
I-Li LIU ◽  
Kenichi YAMAMOTO ◽  
Muneki HONNAMI ◽  
Takamasa SAKAI ◽  
...  
Keyword(s):  
Bone Defect ◽  
Tricalcium Phosphate ◽  
Defect Model ◽  
Large Bone Defect ◽  
Artificial Bones ◽  
Large Bone

scholarly journals A comparative study of tissue-engineered constructs from Acropora and Porites coral in a large animal bone defect model

2017 ◽  
Vol 6 (4) ◽  
pp. 208-215 ◽  
Author(s):  
A. Decambron ◽  
M. Manassero ◽  
M. Bensidhoum ◽  
B. Lecuelle ◽  
D. Logeart-Avramoglou ◽  
...  
Keyword(s):  
Comparative Study ◽  
Bone Defect ◽  
Large Animal ◽  
Defect Model ◽  
Porites Coral ◽  
Animal Bone

scholarly journals Sphingosine-1-phosphate receptor 2 agonist induces bone formation in rat apicoectomy and alveolar bone defect model

2021 ◽  
Author(s):  
Etsuko Matsuzaki ◽  
Haruna Hirose ◽  
Seishiro Fujimasa ◽  
Shohei Yoshimoto ◽  
Tsukasa Yanagi ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Defect ◽  
Alveolar Bone ◽  
Defect Model ◽  
Sphingosine 1 Phosphate ◽  
Alveolar Bone Defect

Bone formation in a rat calvarial defect model after transplanting autogenous bone marrow with beta-tricalcium phosphate

2010 ◽  
Vol 112 (3) ◽  
pp. 270-277 ◽  
Author(s):  
Nobuaki Shirasu ◽  
Takaaki Ueno ◽  
Yasuhisa Hirata ◽  
Azumi Hirata ◽  
Toshimasa Kagawa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Tricalcium Phosphate ◽  
Autogenous Bone ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
Rat Calvarial Defect

The Effects of a Static Magnetic Field on Bone Formation Around a Sandblasted, Large-Grit, Acid-Etched–Treated Titanium Implant

2013 ◽  
Vol 39 (S1) ◽  
pp. 248-255 ◽  
Author(s):  
Richard Leesungbok ◽  
Su-Jin Ahn ◽  
Suk-Won Lee ◽  
Geon-Ho Park ◽  
Joo-Sung Kang ◽  
...  
Keyword(s):  
Bone Formation ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Histomorphometric Analysis ◽  
Contact Ratio ◽  
Neodymium Magnet ◽  
Significant Difference ◽  
Rabbit Tibia ◽  
Group 3 ◽  
The Mean

The purpose of this study was to compare the bone formation around commercial sandblasted, large-grit, acid-etched (SLA)–treated titanium implants with or without a neodymium magnet in a rabbit tibia through histomorphometric analysis. Commercial SLA-treated implants with or without neodymium magnets were placed in 10 rabbits. After incising the flat part of the rabbit's tibia and installation of the specimens of titanium implants, the nonmagnet group was stitched without magnet insertion. On the other hand, the magnet group was inserted with neodymium magnet, fixed with pattern resin, and stitched. At 3 and 6 weeks after surgery, the animals were sacrificed, and the specimens were obtained. Undecalcified specimens were prepared for histomorphometric analysis of the bone-to-implant contact ratio (BIC) and bone volume (BV). The histomorphometric findings of the cortical bone showed that the mean BVs of the magnet group (3 weeks, 75.99%; 6 weeks, 82.94%) were higher than those of the nonmagnet group (3 weeks, 74.58%; 6 weeks, 78.75%), but there were no significant differences between the 2 groups (P > .05). In the marrow bone, the mean BICs of the magnet group (3 weeks, 10.36%; 6 weeks, 10.41%) were higher than those of the nonmagnet group (3 weeks, 6.41%; 6 weeks, 7.36%). After 3 weeks of installation, there was a significant difference between the 2 groups (P < .05). In rabbit tibia, the SLA-treated titanium implants with a neodymium magnet can trigger faster early peri-implant bone formation than those without a magnet.

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