Nanoemulsions Drug Delivery System: Preparations Techniques In Vitro Characterization and Pharmaceutical Application

Nano-emulsions are a novel drug delivery system, in which mix two immiscible liquids, normally oil and water with the addition a proper surfactant and co-surfactant to obtain a single uniform phase, in many cases must be used more than one surfactant to improve the stability of nanoemulsion, in this survey consideration is focused to provide brief information about the formulation, a strategy of preparation, characterization procedure, evaluation parameter as particle size, polydispersity, drug content, zeta potential, and different application of nanoemulsion, it is thermodynamically unsteady colloidal dispersion systems having an average droplet size which ranges from 10 to 200 nm, the decrease in a bead size to nanoscale leads to alter in physical properties such as uncommon elastic behavior and optical transparency and get better bioavailability and good targeting. The formulation of O/W nanoemulsion where hydrophobic drugs are dissolved within the oil phase consider the common approach of nanoemulsion utilization in biomedical application. The essential thought behind these formulations is that nanodroplets act as a medium to transport hydrophobic drugs. The advantage of nanodroplets when compared to the bigger droplet sized emulsions is the upgraded stability and progressed pharmacological activity nanoemulsions have broad applications in numerous areas other than pharmaceutics, like in cosmetics, nourishment and other applications owing to many benefits of nanoemulsion as higher stability versus coalescence, lack of harmfulness or irritant effect, minimal viscosity, good appearance, as well as the flexibility of formulation like liquids, creams in addition to sprays.