Study on the Microstructure and Biocompatibility of Inositol Hexakisphosphate-Modified Titanium Surface

The surface topography and biocompatibility of titanium mesh treated with inositol hexakisphosphate (IP6) was studied. At high concentration of IP6, micro-grooved titanium surface with width of ~ 8 μm was formed. Then, calcium phosphate coating was deposited on the micro-grooves by a second hydrothermal treatment. Furthermore, cell culture results showed that micro-grooved surface could guide cell elongation and stretching along the grooves. Calcium phosphate modified micro-grooved titanium surface enhanced the cell viability compared with the unmodified surface. Therefore, IP6 modification may be a good candidate for improving the biocompatibility of titanium implants.

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Calcium Phosphate Coating on Blast-Treated Titanium Implants by RF Magnetron Sputtering

Materials Science Forum ◽

10.4028/www.scientific.net/msf.631-632.211 ◽

2009 ◽

Vol 631-632 ◽

pp. 211-216 ◽

Cited By ~ 3

Author(s):

Kyosuke Ueda ◽

Takayuki Narushima ◽

Takashi Goto ◽

T. Katsube ◽

Hironobu Nakagawa ◽

...

Keyword(s):

Calcium Phosphate ◽

Magnetron Sputtering ◽

Bonding Strength ◽

Rf Magnetron Sputtering ◽

Titanium Implants ◽

Calcium Phosphate Coating ◽

Phosphate Coating ◽

Coating Films

Calcium phosphate coating films were fabricated on Ti-6Al-4V plates and screw-type implants with a blast-treated surface using radiofrequency (RF) magnetron sputtering and were evaluated in vitro and in vivo. Amorphous calcium phosphate (ACP) and oxyapatite (OAp) films obtained in this study could cover the blast-treated substrate very efficiently, maintaining the surface roughness. For the in vitro evaluations of the calcium phosphate coating films, bonding strength and alkaline phosphatase (ALP) activity were examined. The bonding strength of the coating films to a blast-treated substrate exceeded 60 MPa, independent of film phases except for the film after post-heat-treatment in silica ampoule. When compared with an uncoated substrate, the increase in the ALP activity of osteoblastic SaOS-2 cells on a calcium phosphate coated substrate was confirmed by a cell culture test. The removal torque of screw-type Ti-6Al-4V implants with a blast-treated surface from the femur of Japanese white rabbit increased with the duration of implantation and it was statistically improved by coating an ACP film 2 weeks after implantation. The in vitro and in vivo studies suggested that the application of the sputtered ACP film as a coating on titanium implants was effective in improving their biocompatibility with bones.

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Zinc-doped Calcium Phosphate Coating on Titanium Surface Using Ostrich Eggshell as a Ca2+ Ions Source

Biomaterials and Medical Applications ◽

10.4172/2577-0268.1000107 ◽

2018 ◽

Vol 01 (02) ◽

Author(s):

Ferreira JRM ◽

Louro LHL ◽

Costa AM ◽

Marcal RLSB ◽

Navarro da Rocha D ◽

...

Keyword(s):

Calcium Phosphate ◽

Titanium Surface ◽

Calcium Phosphate Coating ◽

Phosphate Coating ◽

Ostrich Eggshell

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Nano-scale study of the nucleation and growth of calcium phosphate coating on titanium implants

Biomaterials ◽

10.1016/j.biomaterials.2003.09.063 ◽

2004 ◽

Vol 25 (14) ◽

pp. 2901-2910 ◽

Cited By ~ 130

Author(s):

Florence Barrere ◽

Margot M.E. Snel ◽

Clemens A. van Blitterswijk ◽

Klaas de Groot ◽

Pierre Layrolle

Keyword(s):

Calcium Phosphate ◽

Nucleation And Growth ◽

Titanium Implants ◽

Calcium Phosphate Coating ◽

Phosphate Coating ◽

Nano Scale

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Biological performance of biomimetic calcium phosphate coating of titanium implants in the dog mandible

Journal of Biomedical Materials Research Part A ◽

10.1002/jbm.a.10363 ◽

2002 ◽

Vol 64A (2) ◽

pp. 225-234 ◽

Cited By ~ 64

Author(s):

H. Schliephake ◽

D. Scharnweber ◽

M. Dard ◽

S. Röβler ◽

A. Sewing ◽

...

Keyword(s):

Calcium Phosphate ◽

Titanium Implants ◽

Calcium Phosphate Coating ◽

Phosphate Coating ◽

Biological Performance

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A biphasic calcium phosphate coating for potential drug delivery affects early osseointegration of titanium implants

Journal of Oral Pathology and Medicine ◽

10.1111/jop.12464 ◽

2016 ◽

Vol 46 (1) ◽

pp. 61-66 ◽

Cited By ~ 11

Author(s):

Till A. Kämmerer ◽

Victor Palarie ◽

Eik Schiegnitz ◽

Valentin Topalo ◽

Andrea Schröter ◽

...

Keyword(s):

Drug Delivery ◽

Calcium Phosphate ◽

Biphasic Calcium Phosphate ◽

Titanium Implants ◽

Calcium Phosphate Coating ◽

Phosphate Coating ◽

Potential Drug

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Cellular Performance Comparison of Biomimetic Calcium Phosphate Coating and Alkaline-Treated Titanium Surface

BioMed Research International ◽

10.1155/2013/832790 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 5

Author(s):

Xiaohua Yu ◽

Mei Wei

Keyword(s):

Calcium Phosphate ◽

Titanium Surface ◽

Cell Attachment ◽

Substrate Surface ◽

Calcium Phosphate Coating ◽

Osteoblastic Cell ◽

Phosphate Coating ◽

Proliferation And Differentiation ◽

The Impact

The influence of biomimetic calcium phosphate coating on osteoblasts behaviorin vitrois not well established yet. In this study, we investigated the behavior of osteoblastic rat osteosarcoma 17/2.8 cells (ROS17/2.8) on two groups of biomaterial surfaces: alkaline-treated titanium surface (ATT) and biomimetic calcium phosphate coated ATT (CaP). The cell attachment, proliferation, differentiation, and morphology on these surfaces were extensively evaluated to reveal the impact of substrate surface on osteoblastic cell responses. It was found that the ROS17/2.8 cells cultured on the ATT surface had higher attachment and proliferation rates compared to those on the CaP surface. Our results also showed that the calcium phosphate coatings generated in this work have an inhibiting effect on osteoblast adhesion and further influenced the proliferation and differentiation of osteoblast compared to the ATT surfacein vitro. Cells on the ATT surface also exhibited a higher alkaline phosphatase activity than on the CaP surface after two weeks of culture. Immunofluorescence staining and scanning electron microscopy results showed that the cells adhered and spread faster on the ATT surface than on the CaP surface. These results collectively suggested that substrate surface properties directly influence cell adhesion on different biomaterials, which would result in further influence on the cell proliferation and differentiation.

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