Nano-scale study of the nucleation and growth of calcium phosphate coating on titanium implants

Biomaterials ◽  
2004 ◽  
Vol 25 (14) ◽  
pp. 2901-2910 ◽  
Author(s):  
Florence Barrere ◽  
Margot M.E. Snel ◽  
Clemens A. van Blitterswijk ◽  
Klaas de Groot ◽  
Pierre Layrolle
Keyword(s):  
Calcium Phosphate ◽  
Nucleation And Growth ◽  
Titanium Implants ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Nano Scale

Calcium Phosphate Coating on Blast-Treated Titanium Implants by RF Magnetron Sputtering

2009 ◽  
Vol 631-632 ◽  
pp. 211-216 ◽  
Author(s):  
Kyosuke Ueda ◽  
Takayuki Narushima ◽  
Takashi Goto ◽  
T. Katsube ◽  
Hironobu Nakagawa ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Bonding Strength ◽  
Rf Magnetron Sputtering ◽  
Titanium Implants ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Coating Films

Calcium phosphate coating films were fabricated on Ti-6Al-4V plates and screw-type implants with a blast-treated surface using radiofrequency (RF) magnetron sputtering and were evaluated in vitro and in vivo. Amorphous calcium phosphate (ACP) and oxyapatite (OAp) films obtained in this study could cover the blast-treated substrate very efficiently, maintaining the surface roughness. For the in vitro evaluations of the calcium phosphate coating films, bonding strength and alkaline phosphatase (ALP) activity were examined. The bonding strength of the coating films to a blast-treated substrate exceeded 60 MPa, independent of film phases except for the film after post-heat-treatment in silica ampoule. When compared with an uncoated substrate, the increase in the ALP activity of osteoblastic SaOS-2 cells on a calcium phosphate coated substrate was confirmed by a cell culture test. The removal torque of screw-type Ti-6Al-4V implants with a blast-treated surface from the femur of Japanese white rabbit increased with the duration of implantation and it was statistically improved by coating an ACP film 2 weeks after implantation. The in vitro and in vivo studies suggested that the application of the sputtered ACP film as a coating on titanium implants was effective in improving their biocompatibility with bones.

Biological performance of biomimetic calcium phosphate coating of titanium implants in the dog mandible

2002 ◽  
Vol 64A (2) ◽  
pp. 225-234 ◽  
Author(s):  
H. Schliephake ◽  
D. Scharnweber ◽  
M. Dard ◽  
S. Röβler ◽  
A. Sewing ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Titanium Implants ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Biological Performance

A biphasic calcium phosphate coating for potential drug delivery affects early osseointegration of titanium implants

2016 ◽  
Vol 46 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Till A. Kämmerer ◽  
Victor Palarie ◽  
Eik Schiegnitz ◽  
Valentin Topalo ◽  
Andrea Schröter ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Titanium Implants ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Potential Drug

Study on the Microstructure and Biocompatibility of Inositol Hexakisphosphate-Modified Titanium Surface

2014 ◽  
Vol 809-810 ◽  
pp. 507-513
Author(s):  
Dong Qin Xiao ◽  
Zhen Tan ◽  
Cheng Dong Zhang ◽  
Tai Lin Guo ◽  
Ke Duan ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Titanium Surface ◽  
Titanium Implants ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Titanium Mesh ◽  
High Concentration ◽  
Inositol Hexakisphosphate ◽  
Surface Enhanced ◽  
Grooved Surface

The surface topography and biocompatibility of titanium mesh treated with inositol hexakisphosphate (IP6) was studied. At high concentration of IP6, micro-grooved titanium surface with width of ~ 8 μm was formed. Then, calcium phosphate coating was deposited on the micro-grooves by a second hydrothermal treatment. Furthermore, cell culture results showed that micro-grooved surface could guide cell elongation and stretching along the grooves. Calcium phosphate modified micro-grooved titanium surface enhanced the cell viability compared with the unmodified surface. Therefore, IP6 modification may be a good candidate for improving the biocompatibility of titanium implants.

Calcium Phosphate Coated Rapid Prototyped Porous Titanium Scaffolds

2007 ◽  
Vol 361-363 ◽  
pp. 907-910
Author(s):  
Marco A. Lopez-Heredia ◽  
Borhane H. Fellah ◽  
Paul Pilet ◽  
C. Leroux ◽  
M. Dorget ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Calcium Phosphate ◽  
Polarized Light ◽  
Porous Titanium ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Alamar Blue ◽  
Subcutaneous Implantation ◽  
Marrow Mesenchymal Stem Cells ◽  
Rat Bone

Porous Titanium Scaffolds were produced by using a rapid prototyping technique. These scaffolds were either coated or not with a calcium phosphate coating via an eletrodeposition method. Rat bone marrow mesenchymal stem cells were cultured on the scaffolds at a density of 106 cells/scaffold for a period of 3 days. Cell proliferation was measured by using the Alamar Blue assay. The scaffolds were observed by SEM and polarized light microscopy. Constructs were then implanted subcutaneously for 4 weeks in syngenic rats. Cells proliferated well after seeding. After subcutaneous implantation, histology and SEM revealed the presence of uniform coatings as well as Ca and P deposits in the non-coated scaffolds suggesting mineralization.

Hydrothermal Growth of Nano-Hydroxyapatite Coating Formed on Fluorinated Magnesium Alloy and Its Corrosion Behaviour

2021 ◽  
Vol 13 (1) ◽  
pp. 10-19
Author(s):  
Chun-Yan Zhang ◽  
Hao-Lan Fang ◽  
Xin-Peng Liu ◽  
Fan-Cheng Meng ◽  
Zhong-Qing Tian ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
Calcium Phosphate ◽  
Hydrothermal Treatment ◽  
Treatment Time ◽  
Electrochemical Impedance ◽  
Hydrothermal Growth ◽  
Crystal Phase ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Ha Coating

In order to explore the hydrothermal growth mechanism of hydroxyapatite (HA) coating on fluorinated magnesium alloy, the changes of morphology, composition and crystal phase of the calcium phosphate coating during the hydrothermal treatment were studied. And the change of electrochemical impedance spectroscopy (EIS) of the coating specimen of different hydrothermal treatment time was discussed to further understanding the change of the coating structure. The results demonstrated that calcium phosphate could rapidly nucleate on fluorinated AZ31 magnesium alloy. The crystal phase of calcium phosphate coating was mainly octacalcium phosphate (OCP) at the early stage of hydrothermal treatment. Then the content of OCP decreased and the content of HA increased with hydrothermal time. The coating consisted of only HA after hydrothermal treatment for about 4h. The HA coating composed of rod-like crystals exhibited an obvious double layer structure. The rod-like crystals of inner layer arranged into dense bundles and the rod-like crystals of outer layer arranged into loose chrysanthemum-like clusters. Fluoride conversion layer acted as an intermediate transition layer to connect magnesium alloy and HA coating into a whole. The results of immersion test in simulated body fluid demonstrated that HA crystals dissolved slowly. No peeling occurred of HA coating during the 12 days' immersion. Pitting corrosion was still the mainly corrosion mode of magnesium alloy substrate due to the electrolyte infiltration during the immersion.

Laser-Assisted Biomimetic Process for Calcium Phosphate Coating on a Hydroxyapatite Ceramic

2012 ◽  
Vol 529-530 ◽  
pp. 217-222 ◽  
Author(s):  
Ayako Oyane ◽  
Ikuko Sakamaki ◽  
Yoshiki Shimizu ◽  
Kenji Kawaguchi ◽  
Yu Sogo ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Nucleation And Growth ◽  
Calcium Phosphate Coating ◽  
Dependent Manner ◽  
Secondary Nucleation ◽  
Hydroxyapatite Ceramic ◽  
Ethylene Vinyl Alcohol ◽  
Coating Technique ◽  
Laser Absorption ◽  
Dental Applications

The present authors recently developed a new calcium phosphate (CaP) coating technique on an ethylene-vinyl alcohol copolymer substrate utilizing a laser-assisted biomimetic (LAB) process. In the present study, the LAB process was applied to a sintered hydroxyapatite (sHA) substrate for CaP coating. The LAB process was carried out by irradiating the sHA substrate immersed in a supersaturated CaP solution with a low-energy Nd-YAG pulsed laser. Within 30 min of irradiation, contiuous CaP layers with different morphologies were successfully formed on the laser-irradiated sHA surface. A submicron cavernous structure of the CaP layer was developed into a micron flake-like structure as the laser power increased from 1 to 3 W. This result suggests that the secondary nucleation and growth of CaP crystals were accelerated by laser irradiation in a power-dependent manner. Laser absorption by the sHA substrate and the resulting increase in ambient temperature locally near the surface should be responsible for the accelerated CaP nucleation and growth. The present CaP coating technique using the LAB process is simple and quick, hence it would be useful in orthopedic and dental applications as an on-demand surface-functionalization method for biomaterials consisting of sHA.

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