Design and Development of Maritime Data Security Management Platform

Since the e-Navigation strategy was put forward, various countries and regions in the world have researched e-Navigation test platforms. However, the sources of navigation data are multi-source, and there are still difficulties in the unified acquisition, processing, analysis and application of multi-source data. Users often find it difficult to obtain the required comprehensive navigation information. The purpose of this paper is to use e-Navigation architecture to design and develop maritime data security management platform, strengthen navigation safety guarantee, strengthen Marine environment monitoring, share navigation and safety information, improve the ability of shipping transportation organizations in ports, and protect the marine environment. Therefore, this paper proposes a four-layer system architecture based on Java 2 Platform Enterprise Edition (J2EE) technology, and designs a unified maritime data storage, analysis and management platform, which realizes the intelligent, visualized and modular management of maritime data at shipside and the shore. This platform can provide comprehensive data resource services for ship navigation and support the analysis and mining of maritime big data. This paper expounds on the design, development scheme and demonstration operation scheme of the maritime data security management platform from the system structure and data exchange mode.

Assessment of the effectiveness of the use of tumoroids for personalized drug therapies for solid tumors

The approach to the management of cancerous neoplasms, which aims to define the effective curative strategies in each patient, defines the requirement for the elaboration and use of modelling systems that replicate the structures and the biology of human solitary tumors. Three-dimensional cultures of spheroids/tumoroids, which are multi-cell aggregates of malignized cells, can create the intercellular connections of interest, gradients of the nutrients and oxygen, and cell polarity, all of which are absent in the conventional two-dimensional single-layer system. The present work is dedicated to a comparison study of in vitro viability and invasiveness of solid tumor cells of patients under the effect of chemopreparations and their combinations in view of evaluating the efficacy of the 3D-cell modelling system in the translational personalized medicine context. Cell cultures of patients who were treated at the N.N. Petrov National Medicine Research Center of oncology were used as a basis for the development of 3D-cell models. N.N. Petrov NMRC in 2015-2021. Tumor tissue pieces were acquired intraoperatively: 1 - leiomyosarcoma (LMS), 1 - rhabdomyosarcoma (RMS), 1 - synovial sarcoma (SS), 2 - myxofibrosarcoma (MFS), 2 - osteogenic sarcoma (OS), 1 - skin melanoma (MC), 1 - breast cancer (BC) (n=9). Our individual comparison of the effectiveness of in vitro chemotherapeutic agents against tumor cells of various origins cultivated in 2D and 3D model systems with real clinically relevant cases confirmed that the monolayer culture as the test system was less adequate for selecting and personalizing the treatment of malignant tumor patients: the 3D cell system proved itself in 77.7% of cases, and the monolayer culture - in 44.4% of cases. The combination of doxorubicin/iforsfamide and paclitaxel significantly suppressed the motility in the matrigel of spheroid cells, but did not affect tumor cell viability, which was seen in all but OS #921 and MK #929 cases. The cultivation of tumor cells in form of spheroids/tumoroids allows to utilize them as more adequate pre-clinical model as individual predictive test-system, enabling the personalized selection of therapy.

Three-Layer PdO/CuWO4/CuO System for Hydrogen Gas Sensing with Reduced Humidity Interference

The growing hydrogen industry is stimulating an ongoing search for new materials not only for hydrogen production or storage but also for hydrogen sensing. These materials have to be sensitive to hydrogen, but additionally, their synthesis should be compatible with the microcircuit industry to enable seamless integration into various devices. In addition, the interference of air humidity remains an issue for hydrogen sensing materials. We approach these challenges using conventional reactive sputter deposition. Using three consequential processes, we synthesized multilayer structures. A basic two-layer system composed of a base layer of cupric oxide (CuO) overlayered with a nanostructured copper tungstate (CuWO4) exhibits higher sensitivity than individual materials. This is explained by the formation of microscopic heterojunctions. The addition of a third layer of palladium oxide (PdO) in forms of thin film and particles resulted in a reduction in humidity interference. As a result, a sensing three-layer system working at 150 °C with an equalized response in dry/humid air was developed.

Ageing Resistance of Bi-Layer Coating Systems for Dry Lubrication of Premium OCTG Connections

The latest dope-free configuration combines an electrodeposited zinc-nickel (ZnNi) plating, which provides anti-galling and most of anticorrosion properties, and an organic topcoat which provides lubrication through its low friction coefficient. This dry lubrication constitutes an alternative to storage and running dope meanwhile it improves running performances, reduces operational costs on the yard and rig and avoids dope discharge to the environment. Since the technology is "rig-ready", it must withstand the different risks of degradation occurring along its whole lifecycle. The present study aims at assessing the robustness towards ageing along storage on yards, transportation to the rig and or service life in well conditions. The performances of the different layers were checked stepwise, first assessing the ZnNi plating alone, and then considering the additional protection brought by thermoset topcoat. Regarding atmospheric corrosion, the characterization path involved both accelerated laboratory tests (such as the VDA 233-102 cyclic corrosion test) and outdoor exposures, under plastic protectors and after their removal, in different climates: temperate, desertic and tropical. The specimens were inspected regarding at: (i) efficiency of cathodic protection provided by the metallic coating; (ii) paint blistering, (iii) propagation of corrosion from a scribe down to substrate. Regarding rig operations, some examples of rig-return were reported and the compatibility with completion fluids, encountered in case of misrun and subsequent pull-out of the column, was checked though immersion in alkaline brines. In respect to the service in simulated well conditions, the resistance to Stress Corrosion Cracking (SCC) in brines were carried out to complete the former autoclave tests to assess resistance of carbon and stainless steel to well conditions. Both the ZnNi plating and the bi-layer system revealed lifetimes in storage conditions ranging from 3 to more than 5 years before any sign of significant degradation such as red rust, paint blistering or disbonding. According to cyclic corrosion tests results, higher lifetimes could be even expected thanks to the additional anticorrosion protection of the topcoat. Regarding exposure to completion fluids, the bilayer coating was shown to withstand 3000h exposure with no more than scarce rust indications. These results testify of the technology robustness from storage on yards to rig operations. In the multiple service conditions in wells, it was shown that the corrosion and cracking resistance of the substrate was not deteriorated by the plating presence, but instead improved in the multiple assessed well service conditions. The present communication updates the results of atmospheric corrosion compared to the former one [1] and it details new results after rig-return and regarding the risks of cracking.

Passivity-Based Output Feedback Control for Systems with Nonlinear Outputs via High-Gain Observers

In this paper, a high-gain observer with nonlinear output is designed. The scaled estimation error system is constructed with a passive function based on the nonlinear output function and a strictly positive real transfer function of boundary-layer system. The ultimate boundedness and exponential stability of the estimation error for the global and regional two cases are demonstrated, as long as high-gain observer's decay rate is fast enough. For the regional case, due to the restriction on the passive function, the estimation error has a region of attraction which is a subset of the intersection of a positively invariant compact set and the strip coming from the restriction. The extended results under passivity of the output function and strictly positive realness of the transfer function are presented. The performance recovery property of the output feedback using high-gain observer with nonlinear output is validated. Some examples are applied in the simulation to illustrate the proposed results in this paper.

Dynamics of spiral waves and bubble formation in a closed chemical system of thin photosensitive excitable media

Spiral waves have been observed in a thin layer of excitable media. Especially, electrical spiral waves in cardiac tissues connect to cardiac tachycardia and life-threatening fibrillations. The Belousov-Zhabotinsky (BZ) reaction is the most widely used system to study the dynamics of spiral waves in experiments. When the light sensitive Ru(bpy)3 2+ is used as the catalyst, the BZ reaction becomes photosensitive and the excitability of the reaction can be controlled by varying the illumination intensity. However, the typical photosensitive BZ reaction produces many CO2 bubbles so the spiral waves are always studied in thin layer media with opened top surfaces to release the bubbles. In this work, we develop new chemical recipes of the photosensitive BZ reaction which produces less bubbles. To observe the production of bubbles, we investigate the dynamics of spiral waves in a closed thin layer system. The results show that both the speed of spiral waves and the number of bubbles increase with the concentration of sulfuric acid (H2SO4) and sodium bromate (NaBrO3). For high initial concentrations of both reactants, the size of bubbles increases with time until the wave structures are destroyed. We expect that the chemical recipes reported here can be used to study complicated dynamics of three-dimensional spiral waves in thick BZ media where the bubbles cannot escape.

A three-layer system to win the war against COVID-19 and invest in health systems of the future

The COVID-19 pandemic taught us many lessons, most critically that its human and economic toll would have been significantly smaller if countries had in place strong layers of defence that would have either prevented the spillover of the SARS-CoV-2 into a human population in the first place, or, failing that, contained the outbreak to avert its global spread. Further, the brunt of COVID-19 impacts on some countries considered ‘most prepared’ for pandemics underscored the need for an integrated approach to ensure resilience to future epidemics. Consequently, as countries plan ahead to prevent future pandemics, they should give priority to investments that transform their systems, particularly in the precrises phase, to preparedness and response through a multilayered defence. We propose a three-layered approach for post-COVID-19 investments in public health functions and service delivery, particularly at the community and precrises levels. This framework highlights the interventions that enable countries to better prevent, detect and contain epidemic threats, and that strengthen the efficient use of limited resources towards high-impact precrises systems.

A dual pressure indicator, two-layer compression system for treatment of venous leg ulcers: a review

Objective: Venous leg ulcers (VLUs) are considered the most frequent category of hard-to-heal limb ulcers. Although evidence-based care of VLUs suggests that compression therapy plays a pivotal role in the standard of care, patient adherence is considered low, with at least 33% non-compliance, either due to perceived problems from clinicians regarding their own competency in applying the bandages, or from the patient finding the wrapping bothersome. For many years, four-layer bandaging has been considered the ‘gold standard’, but application can be difficult and may also prove uncomfortable for patients. Accurate application may be facilitated by a stretch indicator which has been engineered to act as a surrogate for appropriate pressure application that can address the skill concern, while fewer layers can save clinicians' time and improve the quality of life of patients. Here, we review the literature supporting a two-layer system which combines elastic (long stretch) and inelastic (short stretch) components as well as both layers having graphic markers to define that the dressing has been applied at the proper tension. Method: An initial search was conducted on PubMed and then followed up by a manual search of Google Scholar to retrieve evidence of different levels, in order to evaluate the outcomes of use of the specific two-layer compression system with pressure indicators in the management of patients presenting with VLUs. Results: A total of four papers discussing the specific compression system in question were identified from 32 publications retrieved from PubMed, while a further six were retrieved from Google Scholar. These 10 publications were considered relevant to the two-layer system and were analysed for the outcomes of care, including wound healing, appropriate application, time-saving and better patient acceptance and adherence. Conclusion: Previous authors have demonstrated that two-layer systems are equivalent to four-layer systems. However, the ability to reproducibly apply appropriate compression has remained a question. The papers reviewed demonstrate that evidence suggests that the two-layer compression bandage system with indicators provides continuous, consistent and comfortable treatment that may be easier to apply with accurate pressure levels due to their indicator systems, and therefore, is a procedure that may increase patient adherence and acceptability to the wound therapy.