scholarly journals Effect of oral magnesium supplementation on serum magnesium levels in children recovering from severe acute malnutrition

2021 ◽  
Vol 50 (1) ◽  
pp. 22
Author(s):  
B. Dakshayani ◽  
A. V. Keshav Murthy ◽  
Mallesh Kariyappa
Keyword(s):  
Severe Acute Malnutrition ◽  
Serum Magnesium ◽  
Acute Malnutrition ◽  
Magnesium Supplementation ◽  
Oral Magnesium

scholarly journals Clinical Improvement After Oral Magnesium Supplementation in Children with Severe Acute Malnutrition-An Observational Study

2019 ◽  
Vol 5 (4) ◽  
pp. 209
Author(s):  
Abdullah Al Baki ◽  
A. Z. M. Motiur Rahman ◽  
Md. Shohidul Islam Khan ◽  
Md. Arif Rabbany ◽  
Kamrunnaher Shultana ◽  
...  
Keyword(s):  
Observational Study ◽  
Clinical Improvement ◽  
Severe Acute Malnutrition ◽  
Acute Malnutrition ◽  
Magnesium Supplementation ◽  
Oral Magnesium

scholarly journals Effect of Magnesium Supplementation on Circulating Biomarkers of Cardiovascular Disease

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1697
Author(s):  
Alvaro Alonso ◽  
Lin Y. Chen ◽  
Kyle D. Rudser ◽  
Faye L. Norby ◽  
Mary R. Rooney ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Serum Magnesium ◽  
Interleukin 1 ◽  
Multiple Comparisons ◽  
Tartrate Resistant Acid Phosphatase ◽  
Magnesium Supplementation ◽  
Double Blind ◽  
Baseline Serum ◽  
Protein Levels ◽  
Oral Magnesium

(1) Background: Magnesium supplementation may be effective for the prevention of cardiometabolic diseases, but the mechanisms are unclear. Proteomic approaches can assist in identifying the underlying mechanisms. (2) Methods: We collected repeated blood samples from 52 individuals enrolled in a double-blind trial which randomized participants 1:1 to oral magnesium supplementation (400 mg magnesium/day in the form of magnesium oxide) or a matching placebo for 10 weeks. Plasma levels of 91 proteins were measured at baseline with follow-up samples using the Olink Cardiovascular Disease III proximity extension assay panel and were modeled as arbitrary units in a log2 scale. We evaluated the effect of oral magnesium supplementation for changes in protein levels and the baseline association between serum magnesium and protein levels. The Holm procedure was used to adjust for multiple comparisons. (3) Results: Participants were 73% women, 94% white, and had a mean age of 62. Changes in proteins did not significantly differ between the two intervention groups after correction for multiple comparisons. The most statistically significant effects were on myoglobin [difference −0.319 log2 units, 95% confidence interval (CI) (−0.550, −0.088), p = 0.008], tartrate-resistant acid phosphatase type 5 (−0.187, (−0.328, −0.045), p = 0.011), tumor necrosis factor ligand superfamily member 13B (−0.181, (−0.332, −0.031), p = 0.019), ST2 protein (−0.198, (−0.363, −0.032), p = 0.020), and interleukin-1 receptor type 1 (−0.144, (−0.273, −0.015), p = 0.029). Similarly, none of the associations of baseline serum magnesium with protein levels were significant after correction for multiple comparisons. (4) Conclusions: Although we did not identify statistically significant effects of oral magnesium supplementation in this relatively small study, this study demonstrates the value of proteomic approaches for the investigation of mechanisms underlying the beneficial effects of magnesium supplementation. Clinical Trials Registration: ClinicalTrials.gov NCT02837328.

Hypomagnesemia due to two novel TRPM6 mutations

2015 ◽  
Vol 28 (11-12) ◽  
Author(s):  
Michelle Coulter ◽  
Caroline Colvin ◽  
Bruce Korf ◽  
Ludwine Messiaen ◽  
Benjamin Tuanama ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Seizure Activity ◽  
Neonatal Period ◽  
Serum Magnesium ◽  
Magnesium Concentration ◽  
Magnesium Supplementation ◽  
Generalized Seizures ◽  
Neonatal Hypoparathyroidism ◽  
Hispanic Male ◽  
Oral Magnesium

AbstractAlthough most hypocalcemia with hypomagenesemia in the neonatal period is due to transient neonatal hypoparathyroidism, magnesium channel defects should also be considered.We report a case of persistent hypomagnesemia in an 8-day-old Hispanic male who presented with generalized seizures. He was initially found to have hypomagnesemia, hypocalcemia, hyperphosphatemia and normal parathyroid hormone. Serum calcium normalized with administration of calcitriol and calcium carbonate. Serum magnesium improved with oral magnesium sulfate. However, 1 week after magnesium was discontinued, serum magnesium declined to 0.5 mg/dL. Magnesium supplementation was immediately restarted, and periodic seizure activity resolved after serum magnesium concentration was maintained above 0.9 mg/dL. The child was eventually weaned off oral calcium and calcitriol with persistent normocalemia. However, supraphysiologic oral magnesium doses were necessary to prevent seizures and maintain serum magnesium at the low limit of normal.As his clinical presentation suggested primary renal magnesium wastage,Two novel

scholarly journals Effect of magnesium supplementation on circulating biomarkers of cardiovascular disease

2020 ◽  
Author(s):  
Alvaro Alonso ◽  
Lin Y. Chen ◽  
Kyle D. Rudser ◽  
Faye L. Norby ◽  
Mary R. Rooney ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Serum Magnesium ◽  
Interleukin 1 ◽  
Multiple Comparisons ◽  
Tartrate Resistant Acid Phosphatase ◽  
Magnesium Supplementation ◽  
Baseline Serum ◽  
Protein Levels ◽  
Link Type ◽  
Oral Magnesium

ABSTRACTBackgroundMagnesium supplementation may be effective for the prevention of cardiometabolic diseases, but mechanisms are unclear. Proteomic approaches can assist in identifying underlying mechanisms.MethodsWe collected repeated blood samples in 52 individuals enrolled in a double-blind trial which randomized participants 1:1 to oral magnesium supplementation (400 mg magnesium / day in the form of magnesium oxide) or matching placebo for 10 weeks. Plasma levels of 91 proteins were measured in baseline and follow-up samples using the Olink Cardiovascular Disease III proximity extension assay panel, and modeled as arbitrary units in log2 scale. We evaluated the effect of oral magnesium supplementation on changes in protein levels and the baseline association between serum magnesium and protein levels. The Holm procedure was used to adjust for multiple comparisons.ResultsParticipants were 73% women, 94% white, and had a mean age of 62. Changes in proteins did not significantly differ between the two intervention groups after correction for multiple comparisons. The most statistically significant effects were on myoglobin [difference −0.319 log2 units, 95% confidence interval (CI) (−0.550, −0.088), p = 0.008], tartrate-resistant acid phosphatase type 5 [−0.187, (−0.328, −0.045), p = 0.011], tumor necrosis factor ligand superfamily member 13B [−0.181, (−0.332, −0.031), p = 0.019], ST2 protein [−0.198, (−0.363, −0.032), p =0.020], and interleukin-1 receptor type 1 [−0.144, (−0.273, −0.015), p = 0.029]. Similarly, none of the associations of baseline serum magnesium with protein levels were significant after correction for multiple comparisons.ConclusionThough we did not identify statistically significant effects of oral magnesium supplementation in this relatively small study, this study demonstrates the value of proteomic approaches for the investigation of mechanisms underlying the beneficial effects of magnesium supplementation.Clinical Trials RegistrationClinicalTrials.govNCT02837328

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