scholarly journals The CD40-Induced Signaling Pathway in Endothelial Cells Resulting in the Overexpression of Vascular Endothelial Growth Factor Involves Ras and Phosphatidylinositol 3-Kinase

2004 ◽  
Vol 172 (12) ◽  
pp. 7503-7509 ◽  
Author(s):  
Jesse A. Flaxenburg ◽  
Michael Melter ◽  
Peter H. Lapchak ◽  
David M. Briscoe ◽  
Soumitro Pal
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Endothelial Cells ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Vascular Endothelial ◽  
Phosphatidylinositol 3 Kinase ◽  
Endothelial Growth Factor ◽  
Phosphatidylinositol 3

scholarly journals Sonic hedgehog mediates a novel pathway of PDGF-BB–dependent vessel maturation

Blood ◽  
2014 ◽  
Vol 123 (15) ◽  
pp. 2429-2437 ◽  
Author(s):  
Qinyu Yao ◽  
Marie-Ange Renault ◽  
Candice Chapouly ◽  
Soizic Vandierdonck ◽  
Isabelle Belloc ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Sonic Hedgehog ◽  
Vascular Endothelial ◽  
Phosphatidylinositol 3 Kinase ◽  
Key Points ◽  
Vessel Maturation ◽  
Endothelial Growth Factor ◽  
Phosphatidylinositol 3

Key Points Maturation of vascular endothelial growth factor–induced new vessels in cornea involves a PDGF-Shh axis. Shh promotes PDGF-BB–mediated SMC migration by inducing ERK1/2 and phosphatidylinositol 3-kinase γ activation and increased motility.

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