Arthroscopic Treatment in Early OA of the Knee

2004 ◽  
Vol 39 (1) ◽  
pp. 102
Author(s):  
Sung Jea Kim
TRAUMA ◽  
2017 ◽  
Vol 18 (4) ◽  
pp. 48-53
Author(s):  
V.H. Lutsyshyn ◽  
A.V. Kalashnikov ◽  
O.V. Maiko ◽  
V.M. Maiko

2021 ◽  
Vol 24 ◽  
pp. 264-270
Author(s):  
Ioannis Pantekidis ◽  
Michael-Alexander Malahias ◽  
Stefania Kokkineli ◽  
Emmanouil Brilakis ◽  
Emmanouil Antonogiannakis

1995 ◽  
Vol 26 (4) ◽  
pp. 721-729 ◽  
Author(s):  
Bing Siang Gan ◽  
Robert S. Richards ◽  
James H. Roth

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kuishuai Xu ◽  
Liang Zhang ◽  
Rui Shen ◽  
Cailin Wang ◽  
Tianyu Li ◽  
...  

Abstract Background To explore whether previous arthroscopic knee surgery affects future total knee arthroplasty (TKA) results or not. Methods A total of 56 patients with the previous arthroscopic treatment on one knee underwent subsequent bilateral total knee arthroplasty in our hospital from September 2012 to July 2018. Data on each patient were collected in regards to changes in postoperative clinical and functional scores, various other scores, as well as postoperative functional recovery and complications. We defined the knees with a previous arthroscopic history as group A, and the counter side as group B. The Knee Society clinical score, functional scores, range of motion (ROM), finger joint size (FJS), visual analogue scale (VAS) scores were assessed before and after surgery. Using the Kolmogorov-Smirnov Test to test the normality of continuous variables, and the chi-square test to compare the rate of reoperation and complications between two groups. For all statistical comparisons, P < 0.05 was considered significant. Results There were no statistically significance differences found in postoperative Knee Society clinical scores and functional scores between group A and group B, as well as in ROM, FJS, VAS scores and local complications. Conclusion There were no statistically significant differences found in postoperative functional recovery and complications in patients, who underwent total knee arthroplasty with previous knee arthroscopy.


2021 ◽  
Vol 22 (12) ◽  
pp. 6461
Author(s):  
Marko Ostojic ◽  
Ante Zevrnja ◽  
Katarina Vukojevic ◽  
Violeta Soljic

Synovitis of the knee synovium is proven to be a precursor of knee osteoarthritis (OA), leading to a radiologically advanced stage of the disease. This study was conducted to elucidate the expression pattern of different inflammatory factors—NF-kB, iNOS, and MMP-9 in a subpopulation of synovial cells. Thirty synovial membrane intra-operative biopsies of patients (ten controls, ten with early OA, and ten with advanced OA, according to the Kellgren–Lawrence radiological score) were immunohistochemically stained for NF-kB, iNOS, and MMP9, and for different cell markers for macrophages, fibroblasts, leukocytes, lymphocytes, blood vessel endothelial cells, and blood vessel smooth muscle cells. The total number of CD68+/NF-kB+ cells/mm2 in the intima of early OA patients (median = 2359) was significantly higher compared to the total number of vimentin+/Nf-kB+ cells/mm2 (median = 1321) and LCA+/NF-kB+ cells/mm2 (median = 64) (p < 0.001 and p < 0.0001, respectively). The total number of LCA+/NF-kB+ cells/mm2 in the subintima of advanced OA patients (median = 2123) was significantly higher compared to the total number of vimentin+/NF-kB+ cells/mm2 (median = 14) and CD68+/NF-kB+ cells/mm2 (median = 29) (p < 0.0001). The total number of CD68+/iNOS+ cells/mm2 in the intima of both early and advanced OA patients was significantly higher compared to the total number of vimentin+/iNOS+ cells/mm2 and LCA+/iNOS+ cells/mm2 (p < 0.0001 and p < 0.001, respectively). The total number of CD68+/MMP-9+ cells/mm2 in the intima of both early and advanced OA patients was significantly higher compared to the total number of vimentin+/MMP-9+ cells/mm2 and CD5+/MMP-9+ cells/mm2 (p < 0.0001). Macrophages may have a leading role in OA progression through the NF-kB production of inflammatory factors (iNOS and MMP-9) in the intima, except in advanced OA, where leukocytes could have a dominant role through NF-kB production in subintima. The blocking of macrophageal and leukocyte NF-kB expression is a possible therapeutic target as a disease modifying drug.


2021 ◽  
Author(s):  
Arasch Wafaisade ◽  
Bertil Bouillon ◽  
Maurice Balke ◽  
Paola Kappel

Sign in / Sign up

Export Citation Format

Share Document