Peripheral primitive neuroectodermal tumor of seminal vesicles: Is there a role for relatively aggressive treatment modalities?

A 50 year old white man received an incidental ultrasound diagnosis of hypoechoic mass interesting the right seminal vesicle. A CT scan showed the presence of a 7.8 cm roundish cyst, originating from the right seminal vesicle. He had been followed by the removal of the right seminal vesicle and both the cystic lesion. The histological findings of the specimen documented the presence of small round cells compatible with Ewing’s sarcoma/PPNET. The patient received also adjuvant chemotherapy and radiation treatment. After 10 years, the follow-up is still negative.

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Nasal Sinus Tract of Odontogenic Origin: Report of a Case

Case Reports in Dentistry ◽

10.1155/2015/813478 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5

Author(s):

Sagar Sareen ◽

Anjani Kumar Pathak ◽

Parth Purwar ◽

Jaya Dixit ◽

Divya Singhal ◽

...

Keyword(s):

Holistic Approach ◽

Health Care Research ◽

Sinus Tract ◽

Treatment Modalities ◽

Diagnostic Challenge ◽

Nasal Sinus ◽

Comprehensive Management ◽

Odontogenic Origin ◽

The Right

Extraoral sinus tract often poses a diagnostic challenge to the clinician owing to its rare occurrence and absence of symptoms. The accurate diagnosis and comprehensive management are inevitable as the aetiology of such lesions is often masked and requires holistic approach. The present case report encompasses the management of an extraoral discharging sinus tract at the base of the right nostril in a chronic smoker. The lesion which was earlier diagnosed to be of nonodontogenic origin persisted even after erratic treatment modalities. Our investigations showed the aetiology of sinus tract to be odontogenic. Initially, a five-step program as recommended by the Agency for Health Care Research and Quality was used for smoking cessation followed by root canal therapy (RCT) and surgical management of the sinus tract. The patient has been under stringent follow-up and no reoccurrence has been noted.

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Patient Outcomes after Reirradiation of Small Skull Base Tumors using Stereotactic Body Radiotherapy, Intensity Modulated Radiotherapy, or Proton Therapy

Journal of Neurological Surgery Part B Skull Base ◽

10.1055/s-0039-1694052 ◽

2019 ◽

Vol 81 (06) ◽

pp. 638-644

Author(s):

Sweet Ping Ng ◽

He Wang ◽

Courtney Pollard ◽

Theresa Nguyen ◽

Houda Bahig ◽

...

Keyword(s):

Skull Base ◽

Stereotactic Body Radiotherapy ◽

Radiation Treatment ◽

Intensity Modulated Radiotherapy ◽

Treatment Modalities ◽

Tumor Control ◽

Skull Base Tumors ◽

Intensity Modulated ◽

Grade 3

Abstract Purpose The aim of this study was to evaluate outcomes of patients who received reirradiation for small skull base tumors utilizing either intensity modulated radiotherapy (IMRT), stereotactic body radiotherapy (SBRT), and proton radiotherapy (PRT). Methods Patients who received IMRT, SBRT or PRT reirradiation for recurrent or new small skull base tumors (< 60 cc) between April 2000 and July 2016 were identified. Those with < 3 months follow-up were excluded. Clinical outcomes and treatment toxicity were assessed. The Kaplan–Meier method was used to estimate the local control (LC), regional control (RC), distant control (DC), progression free survival (PFS), and overall survival (OS). Results Of the 75 patients eligible, 30 (40%) received SBRT, 30 (40%) received IMRT, and 15 (20%) received PRT. The median retreatment volume was 28 cc. The median reirradiation dose was 66 Gy in 33 fractions for IMRT/PRT, and 45 Gy in 5 fractions for SBRT. The median time to reirradiation was 41 months. With a median follow-up of 24 months, the LC, RC, DC, PFS, and OS rates were 84%, 79%, 82%, 60%, and 87% at 1 year, and 75%, 72%, 80%, 49%, and 74% at 2 years. There was no difference in OS between radiation modalities. The 1- and 2-year late Grade 3 toxicity rates were 3% and 11% respectively.. Conclusions Reirradiation of small skull base tumors utilizing IMRT, PRT, or SBRT provided good local tumor control and low rates of Grade 3 late toxicity. A prospective clinical trial is needed to guide selection of radiation treatment modalities.

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Intraarterial Thrombolysis with r-tPA for Treatment of Anterior Circulation Acute Ischemic Stroke

Interventional Neuroradiology ◽

10.1177/159101990300900306 ◽

2003 ◽

Vol 9 (3) ◽

pp. 273-282

Author(s):

F. Baltacioğlu ◽

N. Afşar ◽

G. Ekinci ◽

N. Tuncer-Elmaci ◽

N Çagatay Çimşit ◽

...

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Recombinant Tissue Plasminogen Activator ◽

Neurological Status ◽

Treatment Modalities ◽

Anterior Circulation ◽

Main Trunk ◽

History Of ◽

The Right

To investigate factors effecting the safety and recanalization efficacy of local intraarterial (IA) recombinant tissue plasminogen activator (r-tPA) delivery in patients with acute ischemic stroke. Eleven patients with anterior circulation acute ischemic stroke were treated. The neurological status of the patients were graded with the Glasgow Coma Scale (GCS) and National Institute of Health Stroke Scale (NIHSS). All patients underwent a computed tomography (CT) examination at admission. In addition four patients had diffusion-weighted and one patient had a perfusion magnetic resonance (MR) examinations. Patients were treated within six hours from stroke onset. Immediate, six hours, and 24 hours follow-up CT examinations were performed in order to evaluate the haemorrhagic complications and the extent of the ischemic area. The Rankin Scale (RS) was used as an outcome measure. Two of the 11 patients had carotid “T” occlusion (CTO), nine had middle cerebral artery (MCA) main trunk occlusion. Four patients had symptomatic haemorrhage with a large haematoma rupturing into the ventricles and subarachnoid space. Of these, three patients died within 24 hours. The remaining seven patients had asymptomatic haematomas that were smaller compared to symptomatic ones, and showed regression in size and density on follow-up CTs. At third month five patients had a good outcome and three patients had a poor outcome. In acute ischemic stroke, local IA thrombolysis is a feasible treatment when you select the right patient. Haemorrhage rate does not seem to exceed that occuring in the natural history of the disease and in other treatment modalities.

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Peripheral Primitive Neuroectodermal Tumor Arising from the Seminal Vesicle

Urologia Internationalis ◽

10.1159/000112616 ◽

2008 ◽

Vol 80 (2) ◽

pp. 212-216 ◽

Cited By ~ 1

Author(s):

Nathan Lawrentschuk ◽

Sree Appu ◽

Ian Chao ◽

Yee Chan ◽

John Rogerson ◽

...

Keyword(s):

Seminal Vesicle ◽

Primitive Neuroectodermal Tumor ◽

Neuroectodermal Tumor ◽

Peripheral Primitive Neuroectodermal Tumor

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Large ovarian mucinous cystadenoma in premenarchal girl: a case report

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20181955 ◽

2018 ◽

Vol 7 (5) ◽

pp. 2049

Author(s):

Pramod S. ◽

Katragadda Satya Vani

Keyword(s):

Case Report ◽

Cystic Lesion ◽

Mucinous Cystadenoma ◽

Abdominal Distension ◽

Ovarian Tumors ◽

Ovarian Mass ◽

Epithelial Tumor ◽

The Right ◽

Firm Mass

Ovarian tumors are commonly seen in adults and rare in children. Incidence in children is about 2.6 cases per 1,00,000 girls. Most common ovarian mass in children is benign functional cyst. Epithelial tumors account for 8-10% of ovarian tumors. Most common epithelial tumor is Cystadenoma. Mucinous cystadenoma occurs in 3rd -6th decade of life. We report a 10-year-old Premenarchal girl presenting with abdominal distension and discomfort. On examination the entire abdomen was occupied by a firm mass. CT imaging showed a large multiloculated cystic lesion arising from the right ovary. The child underwent right salphingo-oophrectomy. The biopsy of mass was suggestive of benign mucinous cystadenoma. The child is on regular follow up. At 1 year follow up child is doing well.

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Invasive Pulmonary Aspergillosis Mimicking Cyst Hydatics

Acta Medica ◽

10.32552/2019.actamedica.317 ◽

2019 ◽

Vol 50 (3) ◽

pp. 61-64

Author(s):

İsmail Ağababaoğlu ◽

Hasan Ersöz ◽

Filiz Banu Çetinkaya Ethemoğlu ◽

Aydın Şanlı

Keyword(s):

Immune System ◽

Cystic Lesion ◽

Invasive Pulmonary Aspergillosis ◽

Patient History ◽

Pulmonary Aspergillosis ◽

Frequent Form ◽

Histopathologic Diagnosis ◽

The Right ◽

Dual Mesh

Invasive pulmonary aspergillosis (IPA) is a less frequent form and rarely has been reported in normal immune system cases. They do not constitute radiologically cystic structures. A 53-year-old male who was engaged in stock farming and agriculture has no additional disease or habit in the patient history that would compromise the immune system. In thorax computed tomography, a 11x8x10 cm diaphragmatic invasive cystic lesion was seen in the middle and lower lobes of the right lung, was reported that there may be hydatid cyst. The patient underwent right lower bilobectomy and diaphragm resection, diaphragm was reconstructed with a dual mesh. Histopathologic diagnosis was reported as invasive pulmonary aspergillosis. There was no complication or recurrence in the case in the 24-month follow-up period. Thus, a cure was provided for our patient with invasive pulmonary aspergillosis, which was coincidentally diagnosed by pathology in the postoperative period.

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Primitive Neuroectodermal Tumor of Axilla in an Adult: A Rare Entity

10.47363/jccsr/2020(3)165 ◽

2021 ◽

Vol 3 (2) ◽

pp. 1-2

Author(s):

Shravan S Shetty ◽

◽

Vidhi Shah ◽

Eshpuniyani Prriya Prriya ◽

◽

...

Keyword(s):

Primitive Neuroectodermal Tumor ◽

Subcutaneous Tissue ◽

Neuroectodermal Tumor ◽

Round Cell ◽

Primitive Neuroectodermal Tumors ◽

Neuroectodermal Tumors ◽

Poorly Differentiated ◽

The Right ◽

Disease Free

Primitive neuroectodermal tumors (PNETs) are poorly differentiated small round cell neoplasms which mainly affect children and are not commonly seen in adults. Superficial primitive neuroectodermal tumors are rare and have a favourable prognosis compared to conventional deep seated tumors. We report a case of a 62 year old gentleman with a primitive neuroectodermal tumor arising from the subcutaneous tissue of the right axilla. He was treated with multimodal treatment including surgery and radiotherapy. He is alive and disease free at 2 year follow up.

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Anti-PD-1 Immunotherapy Combined With Antiangiogenic Therapy as Salvage Therapy in a Patient With Refractory Metastatic Peripheral Primitive Neuroectodermal Tumor: A Case Report and Literature Review

10.21203/rs.3.rs-772570/v1 ◽

2021 ◽

Author(s):

Qiaoyun Chen ◽

Ronghui Jin ◽

Xu Li ◽

Qifan Wu ◽

Gaili An

Keyword(s):

Primitive Neuroectodermal Tumor ◽

Kinase Inhibitor ◽

Treatment Plan ◽

Antiangiogenic Therapy ◽

Malignant Neoplasm ◽

Neuroectodermal Tumor ◽

Comprehensive Treatment ◽

Peripheral Primitive Neuroectodermal Tumor ◽

New Ideas ◽

The Right

Abstract Background: Peripheral primitive neuroectodermal tumor (pPNET) is a relatively rare malignant neoplasm that usually occurs in children and young adults,associated with poor prognosis. However, standard treatment for refractory pPNET has not been determined.Case presentation: A case of a 38-year-old woman with pPNET on the right shoulder and back,she had gained up to seven-and-a-half years suvival undergoing these comprehensive treatment including surgery, radiotherapy, chemotherapy, antiangiogenic treatment. However, the tumor eventually progressed after receiving multiline treatment.With the patient's strong desire to receive immunotherapy, we finally adjusted the treatment plan to " anti-angiogenic tyrosine kinase inhibitor Lenvatinib combined with PD-1 inhibitor Toripalimab" for 2 cycles.Unfortunately,she developed grade 2-3 immune pneumonia after treatment.Conclusions: To our knowledge, this is the first report of immunotherapy combined with antiangiogenic therapy in pPNET,which provides new ideas for the treatment of refractory pPNET.

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A case of peripheral primitive neuroectodermal tumor of the ovary

International Journal of Gynecological Cancer ◽

10.1136/ijgc-00009577-200403000-00027 ◽

2004 ◽

Vol 14 (2) ◽

pp. 370-372 ◽

Cited By ~ 8

Author(s):

K.-J. Kim ◽

B.-W. Jang ◽

S.-K. Lee ◽

B.-K. Kim ◽

S.-L. Nam

Keyword(s):

Primitive Neuroectodermal Tumor ◽

Soft Tissues ◽

Case Reports ◽

The Body ◽

Neuroectodermal Tumor ◽

Pelvic Cavity ◽

Age Group ◽

Peripheral Primitive Neuroectodermal Tumor ◽

Children And Young Adults ◽

The Right

Peripheral primitive neuroectodermal tumor (PNET) belongs to the PNET/Ewing's sarcoma family. PNET is a small round cell tumor of putative neuroectoderm origin and is the second most common sarcoma among children and young adults. It may occur anywhere in the body and within any age group; however, it is most likely to occur in the bone and soft tissues. There have been a small number of case reports of PNET arising in the ovary. We presented a case of PNET arising in the right ovary of an 18-year-old woman. The tumor was metastased to the lymph nodes of the pelvis and para-aorta at surgical staging. We had persecuted Taxol/carboplatin chemotherapy, pelvic cavity radiotherapy, and Vincristine/Actinomycink, Cyclophosphamide/Doxorubicin (VACA). She died after 10 months due to septic shock.

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Salvage Robotic-Assisted Seminal Vesiculectomy for Merkel Cell Carcinoma Metastasis

Acta Médica Portuguesa ◽

10.20344/amp.15925 ◽

2021 ◽

Vol 34 (13) ◽

Author(s):

Luisa Jerónimo Alves ◽

Bruno Graça ◽

Kris Maes

Keyword(s):

Cell Carcinoma ◽

Seminal Vesicle ◽

Merkel Cell Carcinoma ◽

Lymph Node Involvement ◽

Merkel Cell ◽

Robotic Assisted ◽

Inguinal Lymphadenectomy ◽

Node Involvement ◽

The Right

A 71-year-old male presented with Merkel cell carcinoma along with inguinal lymph node involvement (stage III). The patient was proposed for systemic treatment followed by inguinal lymphadenectomy and adjuvant radiotherapy. During the follow-up period, recurrences were documented (lymphatic and visceral) and were treated with salvage surgery and radiotherapy. On the fifth year of follow-up the patient was diagnosed with a metastasis in the right seminal vesicle and underwent stereotactic body radiation therapy. Two-years later, tumor recurrence in the right seminal vesicle was managed with salvage robotic assisted seminal vesiculectomy. Advanced stages of Merkel cell carcinoma have a poor outcome and salvage treatments should be tailored to each patient. A multidisciplinary approach was crucial in achieving successful outcomes. The patient is still recurrence free twenty-four months after surgery. To the best of our knowledge, this is the first publication reporting a seminal vesical Merkel cell metastasis.

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