scholarly journals View the meniscus: MicroCT strategies for enhancing microstructure visualization

2021 ◽  
Vol 4 (s1) ◽  
Author(s):  
Gregorio Marchiori ◽  
Melania Maglio ◽  
Lucia Martini ◽  
Andrea Visani ◽  
Stefano Zaffagnini ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Functional Assessment ◽  
Imaging Protocols

The optimization of imaging protocols for soft tissue visualization is mandatory in the musculoskeletal field. Combining these techniques with histology and mechanics can provide a comprehensive structural and functional assessment of the tissue.

scholarly journals Quality of life and added value of a tailored palliative care intervention in patients with soft tissue sarcoma undergoing treatment with trabectedin: a multicentre, cluster-randomised trial within the German Interdisciplinary Sarcoma Group (GISG)

BMJ Open ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. e035546
Author(s):  
Leopold Hentschel ◽  
Stephan Richter ◽  
Hans-Georg Kopp ◽  
Bernd Kasper ◽  
Annegret Kunitz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Functional Assessment ◽  
Patient Reported Outcomes ◽  
Statistical Significance ◽  
Case Vignette ◽  
Cluster Randomised ◽  
Patient Reported

ObjectivesThe choice of drug treatment in advanced soft tissue sarcoma (STS) continues to be a challenge regarding efficacy, quality of life (QoL) and toxicity. Unlike other cancer types, where integrating patient-reported outcomes (PRO) has proven to be beneficial for QoL, there is no such evidence in patients with STS as of now. The YonLife trial aimed to explore the effect of a tailored multistep intervention on QoL, symptoms and survival in patients with advanced STS undergoing treatment with trabectedin as well as identifying predictors of QoL.DesignYonLife is a cluster-randomised, open-label, proof-of-concept study. The intervention incorporates electronic PRO assessment, a case vignette and expert-consented treatment recommendations.ParticipantsSix hospitals were randomised to the control arm (CA) or interventional arm (IA). Seventy-nine patients were included of whom 40 were analysed as per-protocol analysis set.Primary and secondary outcome measuresThe primary end point was the change of Functional Assessment for Cancer Therapy (FACT-G) total score after 9 weeks. Secondary outcomes included QoL (FACT-G subscales), anorexia and cachexia (Functional Assessment of Anorexia/Cachexia Therapy (FAACT)), symptoms (MD Anderson Symptom Inventory (MDASI)), anxiety and depression (HADS), pain intensity and interference (Brief Pain Inventory (BPI)) and survival assessment.ResultsAfter 9 weeks of treatment, QoL declined less in the IA (ΔFACT-G total score: −2.4, 95% CI: −9.2 to 4.5) as compared with CA (ΔFACT-G total score: −3.9; 95% CI:−11.3 to 3.5; p=0.765). In almost all FACT-G subscales, average declines were lower in IA, but without reaching statistical significance. Smaller adverse trends between arms were observed for MDASI, FAACT, HADS and BPI scales. These trends failed to reach statistical significance. Overall mean survival was longer in IA (648 days) than in CA (389 days, p=0.110). QoL was predicted by symptom severity, symptom interference, depression and anxiety.ConclusionOur data suggest a potentially favourable effect of an electronic patient-reported outcomes based intervention on QoL that needs to be reappraised in confirmatory studies.Trial registration numberClinicalTrials.gov Identifier (NCT02204111).

Skull base imaging, anatomy, pathology and protocols

2019 ◽  
pp. practneurol-2019-002383
Author(s):  
Bernadine Quirk ◽  
Steven Connor
Keyword(s):  
Soft Tissue ◽  
Skull Base ◽  
Imaging Modality ◽  
Area Of Interest ◽  
Imaging Protocols ◽  
Compartmental Anatomy ◽  
Tissue Interface ◽  
Diagnostic Question ◽  
Neurovascular Structures ◽  
Optimum Imaging

The skull base is the major bony and soft tissue interface for the intracranial and extracranial compartments. Its anatomy is complex, containing multiple traversing foramina that act as conduits for various neurovascular structures. The optimum imaging modality depends on the specific diagnostic question and area of interest; both CT and MR have complementary roles. This article focuses on the applied compartmental anatomy of the skull base and specific imaging protocols, and discusses the range of pathologies that neurologists will encounter.

scholarly journals Functional Assessment After Treatment Of Upper Extremity Soft Tissue Sarcomas Using Structured Outcome Measures: A Systematic Review

2017 ◽  
Vol 20 (9) ◽  
pp. A764
Author(s):  
M Kjäldman ◽  
JP Repo ◽  
M Sampo ◽  
I Barner-Rasmussen ◽  
C Blomqvist ◽  
...  
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
Upper Extremity ◽  
Outcome Measures ◽  
Functional Assessment ◽  
Soft Tissue Sarcomas

Case Series: Superficial Sonography in Urgent Care

2021 ◽  
pp. 875647932110554
Author(s):  
Garth S. Nanni ◽  
Samantha Cofsky
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Imaging Modality ◽  
Low Cost ◽  
Case Series ◽  
Urgent Care ◽  
The Past ◽  
Imaging Protocols ◽  
Diagnostic Applications ◽  
Outpatient Settings

Sonography is an essential imaging modality, known for its real-time capabilities, relative low cost, and multiple diagnostic applications. Although there are protocols which are well-established for specific examinations, there are not clear guidelines for sonographic examinations of soft tissues. Many sonographers have to establish their own imaging protocols when completing a soft tissue examination. This case series details five soft tissue examinations that represent just a few of the clinical requests generated in an Urgent Care (UC) facility. Since UC usage has increased over the past several years, it appears likely that any sonographer working in such outpatient settings will benefit from as much exposure to soft tissue examinations as possible.

scholarly journals Magnetic resonance imaging of the forefoot: A concise, practical overview

2014 ◽  
Vol 18 (2) ◽  
Author(s):  
Mark Velleman
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
Accurate Diagnosis ◽  
Resonance Imaging ◽  
Imaging Protocols

The forefoot may be affected by a wide variety of pathologies that require imaging. Magnetic resonance imaging is the modality of choice for soft-tissue pathologies and occult bone lesions.Correct imaging protocols and an awareness of anatomy are essential for accurate diagnosis.

The ‘Te’ Technique for Restoring Fingertip Stability Post Traumatic Acro-Osteolysis – A Report and Review of Management Options

2017 ◽  
Vol 22 (04) ◽  
pp. 441-444
Author(s):  
Yu-Te Lin ◽  
Charles Yuen Yung Loh
Keyword(s):  
Soft Tissue ◽  
Functional Assessment ◽  
Distal Phalanx ◽  
Management Options ◽  
Non Union ◽  
Tissue Dissociation ◽  
Novel Method ◽  
Post Traumatic ◽  
Bony Fixation

Background: Fractures of the distal phalanx can result in bony non-union, resulting in acro-osteolysis and subsequent fingertip instability due to soft tissue dissociation from bone. Conventional methods of treating this involve osseous fixation, but do not address the laxity and lack of soft tissue stability with bone. Current techniques also do not address the management of such conditions if bony fragments are too small to reduce. We present a novel method that addresses both soft tissue and bony deformity in this condition.Methods: A review of current techniques in the literature is provided as well as an in depth description of our technique using a representative case.Results: Follow-up results and photographs are presented in this article. Functional assessment is also provided in the article as part of the follow-up.Conclusions: This technique is applicable for cases where severe resorption of distal phalanx has occurred, leaving little or no purchase for bony fixation. Hence, the technique can not only be applied post traumatic acro-osteolysis, but also other conditions where secondary soft tissue lengthening occurs and fingertip instability is formed as a result.

Localization of Gallium-67 in Peritoneal Cells by Electron Microscopic Autoradiography

1973 ◽  
Vol 31 ◽  
pp. 404-405
Author(s):  
D. C. Swartzendruber ◽  
Norma L. Idoyaga-Vargas
Keyword(s):  
Clinical Trials ◽  
Soft Tissue ◽  
Tumor Tissue ◽  
Soft Tissue Tumors ◽  
Clinical Usefulness ◽  
Electron Microscopic ◽  
Normal Cells ◽  
Electron Microscopic Autoradiography ◽  
Peritoneal Cells ◽  
Gallium 67

The radionuclide gallium-67 (67Ga) localizes preferentially but not specifically in many human and experimental soft-tissue tumors. Because of this localization, 67Ga is used in clinical trials to detect humar. cancers by external scintiscanning methods. However, the fact that 67Ga does not localize specifically in tumors requires for its eventual clinical usefulness a fuller understanding of the mechanisms that control its deposition in both malignant and normal cells. We have previously reported that 67Ga localizes in lysosomal-like bodies, notably, although not exclusively, in macrophages of the spocytaneous AKR thymoma. Further studies on the uptake of 67Ga by macrophages are needed to determine whether there are factors related to malignancy that might alter the localization of 67Ga in these cells and thus provide clues to discovering the mechanism of 67Ga localization in tumor tissue.

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