scholarly journals Moderate hemoptysis caused by Hughes-Stovin syndrome

2014 ◽  
Vol 4 (3) ◽  
Author(s):  
Sahar El Aoud ◽  
Faten Frikha ◽  
Mouna Snoussi ◽  
Zouhir Bahloul

Hughes and Stovin first reported a syndrome consisting of multiple pulmonary artery aneurysms and venous thrombosis in 1959. Here, we encountered a 42-year old woman who had hemoptysis revealing a Hughes- Stovin syndrome. Helical computed tomography showed multiple pulmonary artery aneurysms with pulmonary thromboembolism. The patient was treated with steroid therapy, cyclophosphamide and anticoagulation with a good response.

2020 ◽  
Vol 10 (1) ◽  
pp. 204589402091068
Author(s):  
Min Liu ◽  
Xin Cao Tao ◽  
Zhenguo Zhai ◽  
Zhanhong Ma ◽  
Li Zhu ◽  
...  

The most common cause of pulmonary artery filling defects on computed tomography pulmonary angiography or magnetic resonance imaging is pulmonary thromboembolism, but not infrequently, the presentation of this finding lacks specificity. Given that the morbidity and mortality associated with pulmonary thromboembolism is high, proper diagnosis of the condition is essential. Unusual or more rarely encountered etiologies must be considered when clinical manifestations and imaging findings are inconsistent. With this review, our purpose is to describe possible causes of pulmonary arterial filling defects. We aim to provide clinicians with a comprehensive list of differential diagnoses to facilitate a measured approach to the assessment of pulmonary arterial filling defects on computed tomography pulmonary angiography or magnetic resonance imaging.


Author(s):  
Ercan Çil ◽  
Gülistan Karadeniz

Objective: The aim of this study is to evaluate the relationship between neutrophil/lymphocyte ratio (NLR) and troponin I levels in patients with pulmonary thromboembolism. Method: The first emergency department admission data of 70 patients hospitalized in the Chest Diseases Department between January 2016 and December 2018 with the diagnosis of non-massive and sub-massive pulmonary thromboembolism were retrospectively reviewed. Data concerning complete blood count, levels of d-dimer, and troponin I, thorax computed tomography angiography and bilateral lower extremity venous Doppler ultrasonography were obtained. Results: The mean age of the patients was 54.1±16.5 years. The female/male ratio was 32 (45.7%) / 38 (54.3%). Troponin I values were 0.027±0.038 ng/mL, and 0.062±0.143 ng/mL in patients with filling defects in the unilateral, and bilateral pulmonary arteries, in thoracic computed tomography angiography respectively. Troponin I elevation was detected in 2 of 25 patients with unilateral, and in 15 of 45 patients with bilateral filling defects. The mean neutrophil/lymphocyte ratios were 4.01±2.51 in patients with unilateral, and 4.73±5.81 in patients with bilateral filling defects. There was no correlation between troponin 1 and neutrophil/lymphocyte ratio. Conclusion: Mean values for troponin 1 levels were higher in pulmonary thromboembolism patients with bilateral pulmonary artery filling defects when compared with those with unilateral pulmonary artery filling defects. However, there was no significant relationship between neutrophil/lymphocyte ratio and troponin I positivity in non-massive and sub-massive pulmonary thromboembolism patients.


2009 ◽  
Vol 17 (5) ◽  
pp. 513-515 ◽  
Author(s):  
Franco Stella ◽  
Fabio Davoli ◽  
Jury Brandolini ◽  
Giampiero Dolci ◽  
Francesco Sellitri ◽  
...  

A 79-year-old woman had a primary tumor of the pulmonary artery, which was initially diagnosed as chronic pulmonary thromboembolism. Multislice angio-computed tomography showed a solid mass in the right pulmonary artery. Radical resection of the tumor was achieved by right pneumonectomy via a transsternal transpericardial approach. The patient was alive and free of disease 36 months after surgery.


2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Selvi Aşker ◽  
Müntecep Aşker ◽  
Özgür Gürsu ◽  
Rıdvan Mercan ◽  
Özgür Bülent Timuçin

Intracardiac thrombus, pulmonary artery aneurysms, deep vein thrombosis, and pulmonary thromboembolism are rarely seen symptoms of Behcet’s disease. A 20-year-old female patient was admitted for complaints of cough, fever, palpitations, and chest pain. On the dynamic thorax computed tomograms (CT) obtained because of significantly enlarged hilar structures seen on chest radiograms, aneurysmal dilatation of the pulmonary artery segments bilaterally, chronic thrombus with collapse, and consolidation substances compatible with pulmonary embolism involving both lower lobes have been observed. It is learned that, four years ago, the patient had been diagnosed with Behcet’s disease and received colchicine treatment but not regularly. The patient was hospitalized. On the transthoracic echocardiogram, a thrombosis with a dimension of 4.2 × 1.6 cm was recognized in the right ventricle. On abdomen CT, aneurysmal iliac veins and deep vein thrombus on Doppler ultrasonograms were diagnosed. At the controls after three months of immunosuppressive and anticoagulant therapies, some clinical and radiological improvements were recognized. The patient suspended the treatment for a month and the thrombus recurred. We present our case in order to show the effectiveness of immunosuppressive and anticoagulant therapies and rarely seen pulmonary thromboembolism in recurrent Behcet’s disease.


Author(s):  
Yasser Emad ◽  
Yasser Ragab ◽  
Cal Robinson ◽  
Sonia Pankl ◽  
Pablo Young ◽  
...  

Abstract Introduction Hughes-Stovin syndrome (HSS) is a systemic vasculitis characterized by widespread venous/arterial thrombosis and pulmonary artery aneurysms (PAAs), which is associated with serious morbidity and mortality. All fatalities reported in HSS resulted from unpredictable fatal suffocating hemoptysis. Therefore, it is necessary to recognize pulmonary complications at an early stage of the disease. Objectives The aims of this study are to develop a reference atlas of images depicting the characteristic features of HSS by computed tomography pulmonary angiography (CTPA). To make a guide for physicians by developing a classification of PAAs according to the severity and risk of complications associated with each distinct lesion type. Methods The Members of the HSS International Study Group (HSSISG) collected 42 cases, with high-quality CTPA images in one radiology station and made reconstructions from the source images. These detailed CTPA studies were reviewed for final image selection and approved by HSSISG board members. We classified these findings according to the clinical course of the patients. Results This atlas describes the CTPA images that best define the wide spectrum of pulmonary vasculitis observed in HSS. Pulmonary aneurysms were classified into six radiographic patterns: from true stable PAA with adherent in-situ thrombosis to unstable leaking PAA, BAA and/or PAP with loss of aneurysmal wall definition (most prone to rupture), also CTPA images demonstrating right ventricular strain and intracardiac thrombosis. Conclusion The HSSISG reference atlas is a guide for physicians regarding the CTPA radiological findings, essential for early diagnosis and management of HSS-related pulmonary vasculitis. Key Points• The Hughes-Stovin syndrome (HSS) is a systemic vasculitis characterized by extensive vascular thrombosis and pulmonary artery aneurysms (PAAs) that can lead to significant morbidity and mortality.• All fatalities reported in HSS were related to unpredictable massive hemoptysis; therefore, it is critical to recognize pulmonary complications at an early stage of the disease.• The HSS International Study Group reference atlas  classifies pulmonary vasculitis in HSS at 6 different stages of the disease process and defines the different radiological patterns of pulmonary vasculitis notably pulmonary artery aneurysms, as detected by computed tomography pulmonary angiography (CTPA).• The main aim of the classification is to make a guide for physicians about this rare syndrome. Such a scheme has never been reached before since the first description of the syndrome by Hughes and Stovin since 1959. This classification will form the basis for future recommendations regarding diagnosis and treatment of this syndrome.


2021 ◽  
Author(s):  
Eda Çelik ◽  
Ömer Araz ◽  
Buğra Kerget ◽  
Elif Yılmazel Uçar ◽  
Metin Akgün ◽  
...  

Abstract Purpose: Acute pulmonary thromboembolism (PTE) is an important cause of morbidity and mortality that can reduce quality of life due to long-term complications during and after treatment discontinuation. The aim of this study was to evaluate patients for these complications before discontinuing treatment and determine the necessity of computed tomography pulmonary angiography (CTPA) imaging.Methods: This retrospective study included 116 patients over the age of 18 who received anticoagulant treatment for at least 3 months and presented for treatment discontinuation to the Atatürk University Research Hospital Chest Diseases Outpatient Clinic between January 2015 and September 2019. Results: CTPA performed at treatment discontinuation showed complete thrombus resolution with treatment in 73 patients (62.9%). High pulmonary artery obstruction index (PAOI) at diagnosis was statistically associated with findings of residual or chronic thrombus on CTPA at treatment discontinuation (p=0.001). In the differentiation of patients with residual/chronic thrombus and those with thrombus resolution, D-dimer at a cut-off value of 474 µg/L had 60% sensitivity and 70% specificity. At a cut-off value of 35.5 mmHg, mean pulmonary artery pressure on echocardiography had sensitivity and specificity of 72% and 77%, respectively. At a cut-off of 23.75, PAOI had sensitivity and specificity of 93% and 69%, respectively.Discussion: In addition to physical examination findings, D-dimer and echocardiography were guiding parameters in the evaluation of treatment discontinuation and thrombus resolution in patients presenting to the outpatient clinic for discontinuation of treatment for acute PTE. PAOI at diagnosis may be another important guiding parameter in addition to these examinations.


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