scholarly journals Misleading hepatitis B serology following rho (D) immune globulin (human) injection and influenza vaccine

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Xuanxuan Chen

Having a hepatitis B surface antibody (HBsAb) titre of more than 10mIU/ml after hepatitis B vaccination is generally considered to confer immunity to hepatitis B. This case report discusses an unusual case of a false positive hepatitis B core total antibody (HBcAb) following administration of either Rho (D) immune globulin (Human) injection or influenza vaccine in a patriuent who was previously immunised against hepatitis B.

2020 ◽  
Vol 9 (2) ◽  
pp. 23-27
Author(s):  
Shailendra Shrestha ◽  
Pratap Roy

Background: Health care workers are in high risk of getting infected with hepatitis B virus. A large proportion of them do not receive a 3-dose series of hepatitis B vaccination and have anti hepatitis B surface antibody titer  <10 mIU/ml. Materials and Methods: Health care workers of the hemodialysis unit were included from March 2019 to March 2020 and were interviewed about hepatitis B vaccination status. Serum samples of the participants were analyzed for anti hepatitis B surface antibody titer. Participants with antibody titer of <10mIU/ml were given a 3-dose series of hepatitis B vaccination and antibody titer was again measured 1-2 months after the last dose. Results: Among 30 participants, 19 (63.3%) had 3-dose series of hepatitis B vaccination, and all of them had anti hepatitis B antibody titer of >10 mIU/ml. Remaining 11 participants (36.7%), with either partial (6) or no hepatitis B vaccination (5), had antibody titer of <10mIU/ml. The mean ranks of antibody titer was significantly associated with the hepatitis B vaccination status (P<0.001). All 11 participants with antibody titer of <10 mIU/ml received a 3-dose series of hepatitis B vaccine and all of them achieved antibody titer >10 mIU/ml. Conclusion: Our study shows that a large proportion of health care workers of hemodialysis unit were either partially or not vaccinated with hepatitis B vaccination and were having anti hepatitis B antibody titer of <10 mIU/ml. However, with complete 3-dose series of hepatitis B vaccination all of them achieved a protective antibody titer of ≥10 mIU/ml.


2020 ◽  
Vol 5 (2) ◽  
pp. 429-431
Author(s):  
Nga-Yeung Tang ◽  
Sarah E Groboske ◽  
Angel D Baldwin ◽  
Kiang-Teck J Yeo ◽  
Xander M R van Wijk

2001 ◽  
Vol 18 (2) ◽  
pp. 123-126 ◽  
Author(s):  
Adil Usman ◽  
Arash Kimyai‐Asadi ◽  
Matthew J. Stiller ◽  
Murad Alam

1997 ◽  
Vol 830 (1 Immunologic D) ◽  
pp. 319-321 ◽  
Author(s):  
M. P. ORLANDO ◽  
S. MASIERI ◽  
M. A. PASCARELLA ◽  
A. CIOFALO ◽  
F. FILIACI

Author(s):  
Jisha Myalil Lucca ◽  
Juny Sebastian ◽  
Mandyam Dhati Ravi ◽  
Gurumurthy Parthasarathi

2021 ◽  
Author(s):  
Xia Zhu ◽  
Juan Wang ◽  
Ming Wang ◽  
Ling-yao Du ◽  
Yu-lin Ji ◽  
...  

Background: Hepatitis B virus (HBV) infection is still a public issue of the world. Hepatitis B vaccination is widely used as an effective measure to prevent HBV infection. This large-sample study aimed to evaluate the positive rates of hepatitis B surface antibody (anti-HBs) in youths after booster vaccination. Methods: A total of 37,788 participants were divided into two groups according to the baseline levels of anti-HBs before booster vaccination: the negative group (anti-HBs (-)); the positive group (anti-HBs (+)). Participants were tested for anti-HBs levels after receiving a booster vaccine 1 year and 4 years. Results: The positive rates of anti-HBs were 34.50%, 73.8% and 67.32% before booster vaccination at 1 year and 4 years after vaccination, respectively. At four years after the booster vaccination, the positive rates of 13 to 18 years were 47.54%, which was the lowest level among all youths age groups. In the anti-HBs (-) group, the positive conversion rates of anti-HBs were 74.62% at 1 year after receiving a booster vaccine, and 67.66% at 4 years after vaccination. In the anti-HBs (+) group, the positive maintenance rates of anti-HBs were 70.16% after 1 year, and 66.66% after 4 years. Compared with the baseline anti-HBs (+) group, the positive rates of the baseline anti-HBs (-) group were higher at 1 year and 4 years after receiving the booster vaccine. Conclusions: The positive rates of anti-HBs declined over time, especially the positive maintenance rates were the lowest at age of 13 to 18 years.


2018 ◽  
Vol 165 (3) ◽  
pp. 201-203
Author(s):  
Keri McLean ◽  
T B Elmer ◽  
D A Freshwater ◽  
L Lamb ◽  
S D Woolley

Assessing for an adequate immunological response to a pre-exposure course of hepatitis B vaccine is not routinely recommended in all vaccinated individuals. Current UK guidelines advise checking hepatitis B surface antibody titres only in those considered at high occupational risk such as healthcare and laboratory workers. We present a case of an infantry soldier who developed acute hepatitis B despite having a complete course of hepatitis B vaccinations. This case emphasises that hepatitis B is still an important differential diagnosis for all returning military personnel who present with compatible symptoms despite being vaccinated.


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