scholarly journals Validation of a spatial liver fluke model under field conditions in Ireland

2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Amalia Naranjo Lucena ◽  
María Pía Munita Corbalán ◽  
Ana María Martínez-Ibeas ◽  
Guy McGrath ◽  
Riona Sayers ◽  
...  
Keyword(s):  
Risk Factors ◽  
Predictive Value ◽  
Liver Fluke ◽  
Fasciola Hepatica ◽  
Vegetation Indices ◽  
Baseline Risk ◽  
New Model ◽  
Explanatory Variables ◽  
Wide Range ◽  
Fluke Infection

Fasciola hepatica is the causative agent of fasciolosis, a global disease of a wide range of mammals, particularly sheep and cattle. Liver fluke infection causes annual losses estimated at around €2.5 billion to livestock and food industries worldwide. Various models have been developed to define risk factors and predict exposure to this liver fluke in ruminants in European countries, most of them based exclusively on data from dairy herds. The aim of this study was to validate a published theoretical baseline risk map of liver fluke exposure and cluster maps in Ireland, by including further explanatory variables and additional herd types that are spatially more widespread. Three approaches were employed: i) comparison of predicted and actual exposure; ii) comparison of cluster distribution of hotspots and coldspots; and iii) development of a new model to compare predicted spatial distribution and risk factors. Based on new survey data, the published baseline predictive map was found to have a sensitivity of 94.7%, a specificity of 5%, a positive predictive value of 60% and a negative predictive value of 38.2%. In agreement with the original model, our validation highlighted temperature and rainfall among the main risk factors. In addition, we identified vegetation indices as important risk factors. Both the previously published and our new model predict that exposure to Fasciola is higher in the western parts of Ireland. However, foci of high probability do not match completely, nor do the location of clusters of hotspots and coldspots.

scholarly journals Predictive risk factors towards liver fluke infection among the people in Kamalasai District, Kalasin Province, Thailand

2019 ◽  
Vol 7 ◽  
pp. 205031211984020 ◽  
Author(s):  
Woragon Wichaiyo ◽  
Wirat Parnsila ◽  
Wisit Chaveepojnkamjorn ◽  
Banchob Sripa
Keyword(s):  
Risk Factors ◽  
Liver Fluke ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Cross Sectional ◽  
The People ◽  
Fluke Infection ◽  
Raw Fish ◽  
Predictive Risk ◽  
Liver Fluke Infection

Background: Liver fluke disease caused by Opisthorchis viverrini remains a major public health problem with its crucial risk factors caused by some individual habits or false beliefs among the people in northeastern Thailand concerning the consumption of raw fish meat dishes. Objectives: This study explores the predictive risk factors for the infection of liver fluke disease. Methods: The sample consisted of 400 people aged 30 years and above in Thanya sub-district, Kamalasai district, Kalasin province. A cross-sectional analytic study, using the χ2 test, odds ratio and 95% confidence interval, was used to find the influence of each variable, along with the use of multiple logistic regression (p = 0.05). A questionnaire form was used as the research instrument. Results: Factors found in the results are as follows: households with a cat were 7.00 times more at risk than households without a cat; eating raw fish dishes prepared by themselves increases the risk of infection by 2.58 times; eating raw fish dishes prepared by family members increases the risk by 4.74 times; and raw fish dishes bought from a community market increases the risk by 2.33 times. Conclusion: A campaign should be launched to educate people not to eat raw or undercooked fish dishes, but to fully cook fish dishes before eating, as the food is still delicious, but also safe, healthy, and free from liver fluke infection.

Immune responses in rats and sheep induced by a DNA vaccine containing the phosphoglycerate kinase gene of Fasciola hepatica and liver fluke infection

2016 ◽  
Vol 61 (2) ◽  
Author(s):  
Agnieszka Wesołowska ◽  
Anna Zawistowska-Deniziak ◽  
Luke J. Norbury ◽  
Przemysław Wilkowski ◽  
Kamil Januszkiewicz ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Liver Fluke ◽  
Fasciola Hepatica ◽  
Phosphoglycerate Kinase ◽  
Kinase Gene ◽  
Phosphoglycerate Kinase Gene ◽  
Fluke Infection ◽  
Liver Fluke Infection

AbstractImmune responses of rats and sheep following vaccination with cDNA encoding phosphoglycerate kinase of

scholarly journals Liver Fluke Control in Beef Cattle

EDIS ◽  
2008 ◽  
Vol 2008 (3) ◽  
Author(s):  
Max B. Irsik ◽  
Charles H. Courtney, III ◽  
Ed Richey
Keyword(s):  
Veterinary Medicine ◽  
Life Cycle ◽  
Beef Cattle ◽  
Liver Fluke ◽  
Fasciola Hepatica ◽  
Large Animal ◽  
Industry Life Cycle ◽  
Fluke Infection ◽  
Liver Fluke Infection ◽  
And Control

Revised! VM-120, a 5-page illustrated fact sheet by M.B. Irsik, Charles Courtney III, and Ed Richey, describes the control of Fasciola hepatica, one of the most damaging parasites in Florida cattle — its life cycle, damage to the animal and industry, life cycle of the intermediate host, diagnosis of liver fluke infection, and control of the liver fluke. Published by the UF College of Veterinary Medicine Large Animal Clinical Sciences Department, July 2007.

Microarray analysis of rat immune responses to liver fluke infection following vaccination with Fasciola hepatica phosphoglycerate kinase

2013 ◽  
Vol 134 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Agnieszka Wesołowska ◽  
Sławomir Jaros ◽  
Luke J. Norbury ◽  
Dorota Jaros ◽  
Wojciech Zygner ◽  
...  
Keyword(s):  
Immune Responses ◽  
Microarray Analysis ◽  
Liver Fluke ◽  
Fasciola Hepatica ◽  
Phosphoglycerate Kinase ◽  
Fluke Infection ◽  
Liver Fluke Infection

Galectin secretion and binding to adult Fasciola hepatica during chronic liver fluke infection of sheep

2012 ◽  
Vol 145 (1-2) ◽  
pp. 362-367 ◽  
Author(s):  
Anna R. Young ◽  
Garry J. Barcham ◽  
Hamish E. McWilliam ◽  
David M. Piedrafita ◽  
Els N. Meeusen
Keyword(s):  
Liver Fluke ◽  
Fasciola Hepatica ◽  
Chronic Liver ◽  
Fluke Infection ◽  
Liver Fluke Infection

Risk factors for intrahepatic cholangiocarcinoma: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Shijie Wang ◽  
Bin Hu ◽  
Yifei Li ◽  
Zhibin Cai ◽  
Yanming Zhou
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver Disease ◽  
Liver Fluke ◽  
Meta Analysis ◽  
Alcoholic Fatty Liver ◽  
Fluke Infection ◽  
Liver Fluke Infection ◽  
Alcoholic Fatty Liver Disease

Abstract Background The incidence of intrahepatic cholangiocarcinoma (ICC) has increased worldwide in recent years, but the risk factors of ICC have not yet been clearly defined. The aim of this study was to identify risk factors for ICC. Methods A literature search was conducted in PubMed database for eligible studies published from January 2000 to November 2018. Summary odds ratio (OR) with their corresponding 95% confidence intervals (CI) were calculated using a random-effects model. Results Thirty-two studies (5 cohort, 27 case control) were included in this meta-analysis. Pooled estimates indicated that cirrhosis (OR=11.96, 95% CI 7.53-19.00), hepatitis B virus (HBV) infection (OR=4.09, 95% CI 3.13-5.34), hepatitis C virus (HCV) infection (OR=3.94, 95% CI 2.85-5.45), alcohol consumption (OR=2.68, 95% CI 1.97-3.66), hepatolithiasis (OR=14.94, 95% CI 6.41-34.83), choledochal cyst (OR=21.67, 95%CI 10.83-43.36), primary sclerosing cholangitis (PSC) (OR=93.91, 95%CI 43.99-200.47), diabetes mellitus (OR=1.82, 95% CI 1.57-2.11), non-alcoholic fatty liver disease (OR=2.23, 95% CI 1.65-3.02), liver fluke infection (OR=2.28, 95% CI 1.30-4.01) and smoking (OR=1.26, 95% CI 1.07-1.49) were significantly associated with ICC. Non-significant association was found between ICC and history of cholecystectomy, hypertension, coffee and aspirin. Conclusions Cirrhosis, HBV infection, HCV infection, alcohol consumption, hepatolithiasis, choledochal cyst, PSC, diabetes mellitus, non-alcoholic fatty liver disease, liver fluke infection and smoking are risk factors for ICC.

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