scholarly journals A case of Aggregatibacter actinomycetemcomitans endocarditis presenting as quadriceps myositis

2012 ◽  
Vol 4 (1) ◽  
pp. 14 ◽  
Author(s):  
Angeline Reid ◽  
Katerina Liew ◽  
Peter Stride ◽  
Robert Horvath ◽  
Jonathan Hunter ◽  
...  
Keyword(s):  
Dental Care ◽  
Transoesophageal Echocardiography ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Full Recovery ◽  
History Of

An 80 year old female was admitted with an eight week history of fever associated with painful swelling of her right thigh, and a long history of poor dentition. Culture of blood stained fluid aspirated from the abscess grew Aggregatibacter actinomycetemcomitans (Aa) sensitive to ampicillin and cephalosporins. Transoesophageal echocardiography indicated endocarditis. Four weeks treatment with intravenous ceftriaxone and appropriate dental care was followed by full recovery.

scholarly journals A Cardiac Pseudoaneurysm as a Thromboembolic Source: Acute Visual Loss due to Cardiac Emboli

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Fernando Montenegro Sá ◽  
Sara I. L. Fernandes ◽  
Rita J. R. Carvalho ◽  
Luís M. G. Santos ◽  
José A. S. Antunes ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Visual Loss ◽  
Central Retinal Artery Occlusion ◽  
Transoesophageal Echocardiography ◽  
Retinal Artery Occlusion ◽  
Artery Occlusion ◽  
Central Retinal Artery ◽  
Acute Visual Loss ◽  
History Of ◽  
Retinal Artery

Acute visual loss is rarely caused by a heart condition. This manuscript transcribes a case report of a 36-year-old patient with a 2-year history of aortic valve replacement due to bicuspid aortic valve endocarditis that presents to the emergency department with an acute right eye visual loss. After ophthalmologic investigation identified a central retinal artery occlusion, a transthoracic echocardiography was performed to search for a possible cardiac embolus, despite the patient presenting INR values of 2-2.5 for the last year. A mitral-aortic intervalvular fibrosa pseudoaneurysm was identified. A transoesophageal echocardiography was then performed, identifying a small clot logged inside the pseudoaneurysm that protruded to the left ventricle outflow tract. After INR-adjusted warfarin treatment to levels between 3 and 4, the pseudoaneurysm was surgically closed. This is a rare case since the likely source of embolism to the central retinal artery was the thrombus logged inside the pseudoaneurysm despite a standardly accepted therapeutic INR.

The history of development of dentistry and dental care in the Stavropol region

2016 ◽  
Vol 9 (2) ◽  
pp. 41
Author(s):  
A. V. Kartashev ◽  
A. K. Kur’yanov ◽  
R. S. Spevak
Keyword(s):  
Dental Care ◽  
History Of Development ◽  
Stavropol Region ◽  
History Of

The Natural History of Adult Trigger Thumb

1993 ◽  
Vol 18 (2) ◽  
pp. 247-248 ◽  
Author(s):  
C. B. SCHOFIELD ◽  
N. D. CITRON
Keyword(s):  
Natural History ◽  
Average Duration ◽  
Adult Patients ◽  
Full Recovery ◽  
Trigger Thumb ◽  
Duration Of Symptoms ◽  
History Of ◽  
Average Loss ◽  
Functional Reduction

30 consecutive adult patients presenting with trigger thumb (31 thumbs) were entered prospectively into a study to determine the natural history of the condition. Five patients insisted on treatment and could not be followed to resolution, but the rest resolved spontaneously after an average duration of symptoms of 6.8 months (range 2–15). There was a small but non-functional reduction in movement of the thumb in some of the patients: six lost an average of 7° of abduction and ten had an average loss of opposition of 1.4 (Kapandji grade). The remaining patients made a full recovery.

scholarly journals Adaptation by Ancient Horizontal Acquisition of Butyrate Metabolism Genes in Aggregatibacter actinomycetemcomitans

mBio ◽  
2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Ahmed M. Moustafa ◽  
Senthil Kumar Velusamy ◽  
Lidiya Denu ◽  
Apurva Narechania ◽  
Daniel H. Fine ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Gene Transfer ◽  
Horizontal Gene Transfer ◽  
Strong Association ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Short Chain ◽  
Oral Microbiota ◽  
Content Type ◽  
History Of ◽  
The Impact

ABSTRACT Like the bacterial residents of the human gut, it is likely that many of the species in the human oral microbiota have evolved to better occupy and persist in their niche. Aggregatibacter actinomycetemcomitans (Aa) is both a common colonizer of the oral cavity and has been implicated in the pathogenesis of periodontal disease. Here, we present a whole-genome phylogenetic analysis of Aa isolates from humans and nonhuman primates that revealed an ancient origin for this species and a long history of association with the Catarrhini, the lineage that includes Old World monkeys (OWM) and humans. Further genomic analysis showed a strong association with the presence of a short-chain fatty acid (SCFA) catabolism locus (atoRDAEB) in many human isolates that was absent in almost all nonhuman OWM isolates. We show that this locus was likely acquired through horizontal gene transfer. When grown under conditions that are similar to those at the subgingival site of periodontitis (anaerobic, SCFA replete), Aa strains with atoRDAEB formed robust biofilms and showed upregulation of genes involved in virulence, colonization, and immune evasion. Both an isogenic deletion mutant and nonhuman primate isolates lacking the ato locus failed to grow in a robust biofilm under these conditions, but grew well under the carbohydrate-rich conditions similar to those found above the gumline. We propose that the acquisition of the ato locus was a key evolutionary step allowing Aa to utilize SCFAs, adapt, and modulate subgingival disease. IMPORTANCE There has been considerable interest in the impact of short-chain fatty acids (SCFAs) on inflammatory effects related to the microbiome. Here, we present evidence that SCFAs may also be important in disease by providing an energy source or disease-associated cue for colonizing pathogens. We propose that SCFAs allow Aggregatibacter actinomycetemcomitans (Aa) to adapt to the subgingival anaerobic environment, which is the site of human periodontitis. Under anaerobic, SCFA-rich conditions, human-derived Aa strains that possess butyrate metabolism genes form strong biofilms and upregulate virulence genes. Our phylogenetic analysis highlights a long history of evolution of Aa with its primate hosts and suggests that the acquisition of butyrate metabolism genes may have been a critical step in allowing Aa to colonize a new niche and cause disease in humans. Overall, this study highlights the important role that horizontal gene transfer may play in microbial adaptation and the evolution of infectious disease.

Bisphosphonates (BP)-related osteonecrosis of the jaw (ONJ): Clinical experience of the “Rete Oncologica di Piemonte e Valle d’Aosta” network

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 18584-18584 ◽  
Author(s):  
V. Fusco ◽  
C. Ortega ◽  
F. Goia ◽  
L. Ciuffreda ◽  
M. Ardine ◽  
...  
Keyword(s):  
Dental Care ◽  
Median Number ◽  
Osteonecrosis Of The Jaw ◽  
X Rays ◽  
Treatment And Prevention ◽  
Dental Procedures ◽  
Network Methods ◽  
History Of ◽  
Previously Treated ◽  
Prospective Trials

18584 Background: ONJ have been recently reported in patients (pts) treated with BP, especially Pamidronate (P) and Zoledronic Acid (Z). Measures of screening, treatment, and prevention have been planned in our regional oncology network. Methods: We evaluated dental history of pts previously treated with BP and/or under treatment in 2005, finding 60 cases of ONJ, but a large number of suspected cases are under investigation/observation. Full details of oncologic and dental history have been collected so far of 43 pts. Results: Pts characteristics: sex: 14/29 M/F; median age 66 years (range 45–81); tumour: 24 breast cancer, 7 prostate cancer; 12 myeloma. BP treatment: 5 P, 14 P changed to Z, 24 Z; median number of infusions: 22 of P (range 12–52), 18 of Z (range 7–43). Site of ONJ: 33 (77%) in mandible, 9 (21%) in maxilla, 1 (2%) in both. Presenting findings included exposed bone or infections (95%), pain, mobile teeth, soft-tissue swelling, nonhealing fistulas . Dental comorbidities were present in all pts and 92 % had precipitating events, as teeth extraction, periodontal surgery, dental implants, or traumatic use of dentures. Conclusions: Our oncology network planned: a) review of all pts treated with BP since 2000, to obtain real estimates of frequency and of possible risk factors; b) screening of all pts under treatment with BP, with panoramic X-rays and maxillofacial surgeon visit (w/o CT or MR scan in selected cases); c) careful evaluation of pts candidate to be treated with BP (as above), with pretherapy dental care if necessary; d) prospective evaluation of incidence in future, after pretherapy dental care policy and avoiding (as possible) surgical dental procedures during BP treatment; e) prospective trials of evaluation of palliative treatment of ONJ and related complications in affected pts (chlorohexidine mouthwashes, antibiotics, metronidazole, hyperbaric oxygen, etc.). No significant financial relationships to disclose.

Unilateral anal sacculectomy for anal sac apocrine gland adenocarcinoma with urethral involvement

2021 ◽  
Vol 12 (8) ◽  
pp. 380-385
Author(s):  
Hayleigh Robbins
Keyword(s):  
Urinary Catheter ◽  
Full Recovery ◽  
Nursing Interventions ◽  
Anal Gland ◽  
Apocrine Gland ◽  
Time Of Surgery ◽  
History Of ◽  
Anal Sac ◽  
Veterinary Hospital ◽  
Catheter Care

The patient presented to a veterinary hospital with a month-long history of ‘scooting’ and a right-sided anal gland mass. A diagnosis of a stage 2 anal sac apocrine gland adenocarcinoma was confirmed, and the patient underwent a right-sided anal sacculectomy. There was involvement of the urethra and adherence to the rectum and a subsequent urethral incision was necessary, which was surgically repaired at the time of surgery. The patient was hospitalised for several weeks postoperatively for urinary catheter care and further nursing interventions. The patient was discharged from hospital 3 weeks after surgery once the urethra had healed sufficiently enough to enable normal micturition and subsequently made a full recovery.

scholarly journals Informing Research in Primary Dental Care: Setting Priorities

2006 ◽  
Vol os13 (3) ◽  
pp. 85-90 ◽  
Author(s):  
Nikolaus Palmer ◽  
Paul Batchelor
Keyword(s):  
Oral Health ◽  
Dental Care ◽  
Health Assessment ◽  
Treatment Modalities ◽  
History Of Research ◽  
Healthcare It ◽  
Delphi Exercise ◽  
History Of ◽  
The Cost ◽  
Evidence Based Dentistry

This paper suggests that priorities for research in primary dental care should follow the examples set in other areas of primary healthcare. It reviews the history of research in primary dental care, since 1990, and goes on to explain how the Delphi exercise, initiated by the Faculty of General Dental Practice (UK), has identified five priority areas for research in primary dental care. These areas are: 1. Research into the application of evidence-based dentistry into practice. 2. The effects of different systems of remuneration on treatment patterns in practice. 3. The oral health assessment on determining recall intervals and its effect on oral health. 4. Factors that influence and affect dentists’ treatment modalities. 5. The evaluation of the cost benefits of whole team training.

scholarly journals Nutritional secondary hyperparathyroidism in a white lion cub (Panthera leo), with concomitant radiographic double cortical line : clinical communication

2004 ◽  
Vol 75 (1) ◽  
Author(s):  
V. Herz ◽  
R.M. Kirberger
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Pelvic Girdle ◽  
Full Recovery ◽  
Panthera Leo ◽  
Multiple Fractures ◽  
Clinical Communication ◽  
Radiographic Findings ◽  
Meat Diet ◽  
History Of

A captive-bred white lion cub was presented with hindquarter pain, lameness and reluctance to move. Radiographs revealed generalised osteoapenia, multiple fractures, a severely collapsed pelvic girdle, bilateral lateral bowing of the scapulae and mild kyphosis of the caudal vertebrae.Adouble cortical line, a distinct sign of osteopaenia, was repeatedly seen on the pelvic limbs, most strikingly along both femurs. Based on radiographic findings and a history of an exclusive meat diet since weaning, a diagnosis of nutritional secondary hyperparathyroidism was made. The diet was changed to a commercial kitten food and the cub was given cage rest for 6 weeks. Signs of pain abated and the cub became more active.A guarded prognosis was given for full recovery, as changes to the pelvis were considered potentially irreversible.

Parental Perspectives of Early Childhood Caries

2011 ◽  
Vol 51 (1) ◽  
pp. 77-85 ◽  
Author(s):  
Inyang A. Isong ◽  
Donna Luff ◽  
James M. Perrin ◽  
Jonathan P. Winickoff ◽  
Man Wai Ng
Keyword(s):  
Early Childhood ◽  
Oral Health ◽  
Dental Care ◽  
Early Childhood Caries ◽  
Semistructured Interviews ◽  
Parental Perspectives ◽  
Health Assessments ◽  
History Of ◽  
Perceptions And Expectations ◽  
Childhood Caries

Background. Parental perspectives of children with early childhood caries may help inform the development and improvement of caries prevention strategies. Objectives. This study aimed to explore parents’ experiences, perceptions, and expectations regarding prevention and management of early childhood caries. Methods. The authors conducted semistructured interviews with 25 parents of children aged 2 to 5 years, with a known history of caries. All interviews were transcribed and coded, and iterative analyses were conducted to identify key emergent themes within the data. Results. Parents had limited knowledge of behaviors contributing to early childhood caries and when to first seek regular dental care. Parents expected pediatricians to provide education on how to prevent childhood caries, conduct preliminary oral health assessments, and help establish early linkages between medical and dental care. Conclusion. The findings make a strong case for pediatricians to take responsibility for engaging and educating parents on fostering optimal oral health and helping to access early childhood dental care.

Subpar Utilization of Dental Care Among Americans With a History of Stroke

2011 ◽  
Vol 20 (3) ◽  
pp. 255-259 ◽  
Author(s):  
Nerses Sanossian ◽  
Nicole M. Gatto ◽  
Bruce Ovbiagele
Keyword(s):  
Dental Care ◽  
History Of
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