scholarly journals Dietary calcium intake in a cohort of elderly patients already in drug therapy for osteoporosis. Is it possible and how to modify the eating habits before calcium supplementation?

2015 ◽  
Vol 10 (1) ◽  
pp. 42
Author(s):  
Ciro Manzo ◽  
Maria Teresa Russo
Keyword(s):  
Drug Therapy ◽  
Elderly Patients ◽  
Dietary Intake ◽  
Calcium Intake ◽  
Eating Habits ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Outpatient Clinics ◽  
Dietary Calcium Intake ◽  
Average Period

Inadequate intake of calcium via the diet is very common in patients taking drugs for osteoporosis. We have evaluated 302 consecutive elderly patients (68.6 median age) attending our Rheumatological and Orthopedic Outpatient Clinics using a questionnaire for evaluation of dietary calcium intake. Two hundred and forty of these had a questionnaire score 7 in 205/240 after an average period of 3-6 months. In the 35 patients in which this was not possible, the exact knowledge of calcium dietary intake (poor or absent) has allowed a tailored calcium supplementation.

scholarly journals Dietary Calcium Intake and Calcium Supplementation in Hungarian Patients with Osteoporosis

2013 ◽  
Vol 2013 ◽  
pp. 1-8
Author(s):  
Gábor Speer ◽  
Pál Szamosujvári ◽  
Péter Dombai ◽  
Katalin Csóré ◽  
Kinga Mikófalvi ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Calcium Intake ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Current Recommendation ◽  
High Calcium Intake ◽  
Osteoporosis Therapy ◽  
Average Intake ◽  
High Calcium

Purpose. Adequate calcium intake is the basis of osteoporosis therapy—when this proves insufficient, even specific antiosteoporotic agents cannot exert their actions properly.Methods. Our representative survey analyzed the dietary intake and supplementation of calcium in 8033 Hungarian female and male (mean age: 68 years) (68.01 (CI95: 67.81–68.21)) patients with osteoporosis.Results. Mean intake from dietary sources was665±7.9 mg (68.01 (CI95: 67.81–68.21)) daily. A significant positive relationship could be detected between total dietary calcium intake and lumbar spine BMD (P=0.045), whereas such correlation could not be demonstrated with femoralT-score. Milk consumption positively correlated with femur (P=0.041), but not with lumbar BMD. The ingestion of one liter of milk daily increased theT-score by 0.133. Average intake from supplementation was558±6.2 mg (68.01 (CI95: 67.81–68.21)) daily. The cumulative dose of calcium—from both dietary intake and supplementation—was significantly associated with lumbar (r=0.024,P=0.049), but not with femur BMD (r=0.021,P=0.107). The currently recommended 1000–1500 mg total daily calcium intake was achieved in 34.5% of patients only. It was lower than recommended in 47.8% of the cases and substantially higher in 17.7% of subjects.Conclusions. We conclude that calcium intake in Hungarian osteoporotic patients is much lower than the current recommendation, while routinely applied calcium supplementation will result in inappropriately high calcium intake in numerous patients.

Dietary calcium, defective cellular Ca2+ handling, and arterial pressure control

1994 ◽  
Vol 72 (8) ◽  
pp. 937-944 ◽  
Author(s):  
David A. McCarron ◽  
Daniel Hatton ◽  
Jean-Baptiste Roullet ◽  
Chantal Roullet
Keyword(s):  
Blood Pressure ◽  
Clinical Trials ◽  
Calcium Intake ◽  
Inverse Relationship ◽  
Spontaneously Hypertensive Rat ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Calcium Handling ◽  
Dietary Calcium Intake ◽  
Experimental Hypertension

The association between dietary calcium intake, calcium metabolism, and blood pressure form the basis of this review. Epidemiologic data consistently show an inverse relationship between dietary calcium and blood pressure. Clinical trials of calcium supplementation have not been as consistent in outcome. Approximately two-thirds of the supplementation studies have found a beneficial effect of calcium on blood pressure. The lack of consistency in outcome from the clinical trials relative to the epidemiological literature may be related to calcium intake. The epidemiological literature indicates an inverse relationship between calcium intake and blood pressure, with those individuals with the lowest calcium intake (< 700 mg/day) having the highest blood pressure. Clinical studies utilizing patients with high baseline calcium levels (> 700 mg/day) may not see an effect of calcium supplementation on blood pressure because of a ceiling effect. Supplemental calcium appears to correct a defect in calcium handling characterized by a renal calcium leak, increased circulating parathroid hormone, and increased intracellular calcium levels. In part, the deficit in cellular calcium homeostasis may be a consequence of abnormal calmodulin activity. Specifically, it appears that calmodulin activity is diminished in experimental hypertension and that increasing dietary calcium may improve calmodulin activity in the spontaneously hypertensive rat. The deficit in calmodulin activity has the potential to interfere with a number of cellular processes crucial to the regulation of cell function and maintenance of appropriate vascular tone. It is concluded that additional research should be directed toward understanding the ramifications of altered calmodulin activity in hypertension and the influence that dietary calcium can have on the activity of calmodulin.Key words: hypertension, dietary Ca2+, calmodulin, Ca2+ metabolism, calcium channel blockers.

scholarly journals Biochemical effects of calcium supplementation in postmenopausal women: influence of dietary calcium intake

1998 ◽  
Vol 67 (6) ◽  
pp. 1273-1278 ◽  
Author(s):  
P Fardellone ◽  
M Brazier ◽  
S Kamel ◽  
J Guéris ◽  
A M Graulet ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Calcium Intake ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Biochemical Effects

Calcium supplementation affects bone collagen degradation in post-menopausal women with low dietary calcium intake

1996 ◽  
Vol 6 (S1) ◽  
pp. 270-270
Author(s):  
S. Kamel ◽  
M. Brazier ◽  
P. Fardellone ◽  
Y. Rigault ◽  
JP Berrou ◽  
...  
Keyword(s):  
Calcium Intake ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Collagen Degradation ◽  
Bone Collagen ◽  
Dietary Calcium Intake ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals Effect of habitual dietary calcium intake on calcium supplementation in 12–14-y-old girls

2004 ◽  
Vol 80 (5) ◽  
pp. 1422-1427 ◽  
Author(s):  
Christian Mølgaard ◽  
Birthe L Thomsen ◽  
Kim F Michaelsen
Keyword(s):  
Calcium Intake ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Dietary Calcium Intake

Vitamin D Metabolism in Adult Rats at Low and Normal Calcium Intake and the Effect of Cadmium Exposure

1977 ◽  
Vol 53 (5) ◽  
pp. 439-446
Author(s):  
R. Lorentzon ◽  
S.-E. Larsson
Keyword(s):  
Vitamin D ◽  
Dietary Intake ◽  
Intestinal Mucosa ◽  
Vitamin D3 ◽  
Calcium Intake ◽  
Dietary Calcium ◽  
Cadmium Exposure ◽  
Dietary Calcium Intake ◽  
Adult Rats ◽  
25 Hydroxycholecalciferol

1. Chromatography measurements indicated that adult rats converted 25-hydroxycholecalciferol into 1,25-dihydroxycholecalciferol at a lower rate than that reported earlier for young animals. In serum, less-polar metabolites were found which probably represented vitamin D esters and vitamin D3. 2. A low dietary intake of calcium resulted in an evident increase in the fraction corresponding to 1,25-dihydroxycholecalciferol in the kidneys and also in the intestinal mucosa and serum. 3. Inclusion of 0·67 mmol of cadmium/l of drinking water at a low dietary intake of calcium resulted in an increased accumulation of both cadmium and zinc in the kidneys and liver compared with values at a normal dietary calcium intake. 4. At a normal dietary calcium intake, cadmium exposure caused inhibited production of 1,25-dihydroxycholecalciferol by the kidneys and an increased accumulation of 24,25-dihydroxycholecalciferol, vitamin D3 and vitamin D esters in the serum. 5. The inhibitory effect of cadmium on the renal conversion of 25-hydroxycholecalciferol into 1,25-dihydroxycholecalciferol was almost completely counteracted by a simultaneous low dietary calcium intake. Cadmium-exposed, calcium-deficient animals also showed a maintained accumulation of 1,25-dihydroxycholecalciferol in the intestinal mucosa.

scholarly journals Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis

2020 ◽  
Author(s):  
Tiberiu A. Pana ◽  
Mohsen Dehghani ◽  
Hamid Reza Baradaran ◽  
Samuel R. Neal ◽  
Adrian D. Wood ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Mortality ◽  
Calcium Intake ◽  
Prospective Cohort ◽  
Calcium Supplementation ◽  
Meta Analysis ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Mortality Data ◽  
All Cause Mortality

AbstractThe role of dietary calcium in cardiovascular disease prevention is unclear. We aimed to determine the association between calcium intake and incident cardiovascular disease and mortality. Data were extracted from the European Prospective Investigation of Cancer, Norfolk (EPIC-Norfolk). Multivariable Cox regressions analysed associations between calcium intake (dietary and supplemental) and cardiovascular disease (myocardial infarction, stroke, heart failure, aortic stenosis, peripheral vascular disease) and mortality (cardiovascular and all-cause). The results of this study were pooled with those from published prospective cohort studies in a meta-analsyis, stratifying by average calcium intake using a 700 mg/day threshold. A total of 17,968 participants aged 40–79 years were followed up for a median of 20.36 years (20.32–20.38). Compared to the first quintile of calcium intake (< 770 mg/day), intakes between 771 and 926 mg/day (second quintile) and 1074–1254 mg/day (fourth quintile) were associated with reduced all-cause mortality (HR 0.91 (0.83–0.99) and 0.85 (0.77–0.93), respectively) and cardiovascular mortality [HR 0.95 (0.87–1.04) and 0.93 (0.83-1.04)]. Compared to the first quintile of calcium intake, second, third, fourth, but not fifth quintiles were associated with fewer incident strokes: respective HR 0.84 (0.72–0.97), 0.83 (0.71–0.97), 0.78 (0.66–0.92) and 0.95 (0.78–1.15). The meta-analysis results suggest that high levels of calcium intake were associated with decreased all-cause mortality, but not cardiovascular mortality, regardless of average calcium intake. Calcium supplementation was associated with cardiovascular and all-cause mortality amongst women, but not men. Moderate dietary calcium intake may protect against cardiovascular and all-cause mortality and incident stroke. Calcium supplementation may reduce mortality in women.

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