scholarly journals Psychopathology and urine toxicology in methadone patients

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Gamal Sadek ◽  
Zack Cernovsky ◽  
Simon Chiu
Keyword(s):  
Psychotic Symptoms ◽  
Social Self ◽  
Check List ◽  
Obsessive Compulsive ◽  
Paranoid Ideation ◽  
Compulsive Disorder ◽  
Self Confidence ◽  
Urine Toxicology ◽  
Symptom Check List ◽  
Methadone Patients

Several studies reported high rates of psychiatric commorbidity among methadone patients. We examined the relationships of measures of psychopathology to outcomes of screening urine tests for cocaine, opiates, and benzodiazepines in a sample of 56 methadone patients. They also completed the Symptom Check List-90-Revised (SCL-90-R). The highest scales in the SCL-90-R profile of our patients were those indicating somatic discomfort, anger, phobic anxiety, paranoid ideation, and also obsessive-compulsive disorder symptoms (scores above the 39th percentile). The only significant correlations between urine tests and SCL-90-R psychopathology were those involving benzodiazepines: patients with urine tests positive for benzodiazepines had lower social self-confidence (r=0.48), were more obsessive-compulsive (r=0.44), reported a higher level of anger (r=0.41), of phobic tendencies (r=40), of anxiety (r=0.39), and of paranoid tendencies (r=0.38), and also reported more frequent psychotic symptoms (r=0.43).

scholarly journals Psychopathology and urine toxicology in methadone patients

2015 ◽  
Vol 7 (1) ◽  
pp. 16-17
Author(s):  
Gamal Sadek ◽  
Zack Cernovsky ◽  
Simon Chiu
Keyword(s):  
Psychotic Symptoms ◽  
Social Self ◽  
Check List ◽  
Obsessive Compulsive ◽  
Paranoid Ideation ◽  
Compulsive Disorder ◽  
Self Confidence ◽  
Urine Toxicology ◽  
Symptom Check List ◽  
Methadone Patients

Several studies reported high rates of psychiatric commorbidity among methadone patients. We examined the relationships of measures of psychopathology to outcomes of screening urine tests for cocaine, opiates, and benzodiazepines in a sample of 56 methadone patients. They also completed the Symptom Check List-90-Revised (SCL-90-R). The highest scales in the SCL-90-R profile of our patients were those indicating somatic discomfort, anger, phobic anxiety, paranoid ideation, and also obsessive-compulsive disorder symptoms (scores above the 39th per centile). The only significant correlations between urine tests and SCL-90-R psychopathology were those involving benzodiazepines: patients with urine tests positive for benzodiazepines had lower social self-confidence (r=0.48), were more obsessive-compulsive (r=0.44), reported a higher level of anger (r=0.41), of phobic tendencies (r=40), of anxiety (r=0.39), and of paranoid tendencies (r=0.38), and also reported more frequent psychotic symptoms (r=0.43).

scholarly journals Should we screen patients' relatives for psychological status, signs and symptoms in the emergency department? A cross-sectional survey using the Symptom Check List (SCL-90)

2021 ◽  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Psychological Symptoms ◽  
Psychological Symptom ◽  
Psychological Status ◽  
Sociodemographic Characteristics ◽  
Emergency Setting ◽  
Check List ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Symptom Check List

Objectives: The objectives were to investigate psychological symptoms in patients’ relatives (PR), coming into the ED with their patient and to evaluate the relationship between sociodemographic characteristics and psychological symptom scores. Methods: PR in the ED of Cerrahpasa Faculty of Medicine aged 18 years and older were included into the study. Symptom Check List- Revised (SCL-90-R) was administered to 120 PR and sociodemographic characteristics of all were recorded. Results: The majority of the PR were female (n = 66, 55%), graduate of high school (n = 46, 38.3%) and self-employed (n = 22, 18.3%). The highest mean score on SCL-90-R was found on obsessive-compulsive disorder and the lowest scores were found on phobic anxiety. The mean score was higher than 1.0 on obsessive-compulsive disorder, somatization, interpersonal sensitivity, depression and paranoid ideation. There was no correlation between education level, duration of hospitalization and SCL-90 scores. Mean general, somatization, obsessive-compulsive and depression scores of females were found to be significantly higher than of males. Conclusion: High scores in psychological symptoms were observed in PR in the ED. Therefore, besides assessment of the psychological status of patients; it is recommended that PR should be evaluated carefully in this regard and given necessary psychosocial support in the emergency setting.

scholarly journals Schizophrenia-spectrum psychopathology in obsessive–compulsive disorder: an empirical study

2019 ◽  
Vol 270 (8) ◽  
pp. 993-1002 ◽  
Author(s):  
Andreas Rosén Rasmussen ◽  
Julie Nordgaard ◽  
Josef Parnas
Keyword(s):  
Diagnostic Criteria ◽  
Obsessive Compulsive Disorder ◽  
Psychotic Symptoms ◽  
Main Diagnosis ◽  
Schizophrenia Spectrum Disorders ◽  
Obsessive Compulsive ◽  
Main Research ◽  
Compulsive Disorder ◽  
Diagnostic Potential ◽  
Schizophrenia Spectrum

Abstract The differential diagnosis of obsessive–compulsive disorder (OCD) and schizophrenia-spectrum disorders can be difficult. In the current diagnostic criteria, basic concepts such as obsession and delusion overlap. This study examined lifetime schizophrenia-spectrum psychopathology, including subtle schizotypal symptomatology and subjective anomalies such as self-disorders, in a sample diagnosed with OCD in a specialized setting. The study also examined the differential diagnostic potential of the classic psychopathological notions of true obsession (‘with resistance’) and pseudo-obsession. The study involved 42 outpatients diagnosed with OCD at two clinics specialized in the treatment of OCD. The patients underwent semi-structured, narrative interviews assessing a comprehensive battery of psychopathological instruments. The final lifetime research-diagnosis was based on a consensus between a senior clinical psychiatrist and an experienced research clinician. The study found that 29% of the patients fulfilled criteria of schizophrenia or another non-affective psychosis as main, lifetime DSM-5 research-diagnosis. Another 33% received a research-diagnosis of schizotypal personality disorder, 10% a research-diagnosis of major depression and 29% a main research-diagnosis of OCD. Self-disorders aggregated in the schizophrenia-spectrum groups. True obsessions had a specificity of 93% and a sensitivity of 58% for a main diagnosis of OCD. In conclusion, a high proportion of clinically diagnosed OCD patients fulfilled diagnostic criteria of a schizophrenia-spectrum disorder. The conspicuous obsessive–compulsive symptomatology may have resulted in a disregard of psychotic symptoms and other psychopathology. Furthermore, the differentiation of obsessions from related psychopathological phenomena is insufficient and a conceptual and empirical effort in this domain is required in the future.

Differences in the symptom check list‐90 profiles of black and white methadone patients

1989 ◽  
Vol 45 (2) ◽  
pp. 342-345
Author(s):  
Jerome J. Platt ◽  
Robert A. Steer ◽  
William F. Ranieri ◽  
David S. Metzger
Keyword(s):  
Check List ◽  
Black And White ◽  
Symptom Check List ◽  
Methadone Patients

scholarly journals Undergraduate students’ norms for the Chinese version of the symptom check-List-90-R (SCL-90-R)

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yulan Yu ◽  
Chonghua Wan ◽  
Xudong Zhao ◽  
E. Scott Huebner ◽  
Jianfeng Tan ◽  
...  
Keyword(s):  
Mental Health ◽  
Undergraduate Students ◽  
Severity Index ◽  
Chinese Version ◽  
Check List ◽  
Global Severity Index ◽  
Paranoid Ideation ◽  
Widespread Application ◽  
Symptom Check List ◽  
The Mean

Abstract Background Despite widespread application of the Symptom Check-List-90-R (SCL-90-R) for Chinese undergraduate students, there are no appropriate norms for them. The aim of this study is to provide norms for the Chinese version of the tool for undergraduate students using a large and representative sample. Methods Four thousand eight hundred sixty students completed the scale of SCL-90. The mean scores obtained in the present study were compared with mean scores from previous normative samples. Results The mean scores for nine subscales of the SCL-90-R ranged from (1.36 ± 0.46) ~ (1.77 ± 0.63) and the mean (standard deviation) Global Severity Index (GSI) was 1.50 (0.49). Relative to previous normative studies, the findings suggested that Chinese undergraduate students’ self-reported mental health symptoms decreased in interpersonal sensitivity, depression, hostility, and paranoid ideation subscales. Conclusion It is necessary to revise the norms of the Chinese version of the SCL-90-R for undergraduate students.

Obsessive–compulsive symptoms in schizophrenia: a review

2018 ◽  
Vol 31 (2) ◽  
pp. 63-73 ◽  
Author(s):  
Sandeep Grover ◽  
Swapnajeet Sahoo ◽  
Indu Surendran
Keyword(s):  
Psychotic Symptoms ◽  
Limited Data ◽  
Behaviour Therapy ◽  
Obsessive Compulsive ◽  
Initial Attempt ◽  
Compulsive Disorder ◽  
Symptom Profile ◽  
Cognitive Behaviour ◽  
Obsessive Compulsive Symptom ◽  
At Risk Mental State

AbstractObjectiveTo review the available literature on obsessive–compulsive symptom (OCS)/obsessive–compulsive disorder (OCD) in patients with schizophrenia.MethodologyElectronic searches were carried out to locate studies reporting various aspects of OCS/OCD in patients with schizophrenia.ResultsAvailable evidence suggests that prevalence of OCS/OCD in patients with schizophrenia is much higher than prevalence in general population and it is seen in all the stages of schizophrenia, starting from at risk mental state to chronic/stabilisation/deficit phases. Symptom profile of OCS/OCD in schizophrenia is similar to that seen in patients with OCD only. Presence of OCS/OCD is associated with higher severity of symptoms of schizophrenia and more negative outcome. At present there is very limited data on the efficacy/effectiveness of various pharmacological measures and psychological interventions, for management of OCS/OCD in patients with schizophrenia. There is some evidence pointing towards beneficial effect of certain antipsychotics, antidepressants and cognitive behaviour therapy. Management of OCS/OCD in patients with schizophrenia involves proper assessment. If the OCS/OCD is related to use of particular antipsychotic use, initial attempt must be made to reduce the dose of antipsychotics, however, if this is not effective, than addition of a selective serotonin reuptake inhibitor (SSRIs) must be considered. If the OCS/OCD is not related to the use of antipsychotic medication, than depending up on the severity of psychotic symptoms, addition of SSRIs must be considered.ConclusionThis review suggests that OCS/OCD is highly prevalent among patients with schizophrenia and there is limited good quality evidence to make any specific recommendations for management.

The Expanding Role of Antipsychotics

CNS Spectrums ◽  
2004 ◽  
Vol 9 (S1) ◽  
pp. 7-12
Author(s):  
Philip G. Janicak
Keyword(s):  
Bipolar Disorder ◽  
Manic Episode ◽  
Acute Mania ◽  
Psychotic Symptoms ◽  
Primary Therapy ◽  
Obsessive Compulsive ◽  
Stabilizing Agent ◽  
Compulsive Disorder ◽  
Bipolar Patients

Antipsychotics have been utilized in the treatment of bipolar disorder for many decades and were the mainstay of treatment before lithium was reintroduced in the late 1960s. Today, many bipolar patients who present with psychotic features are misdiagnosed and prescribed an antipsychotic for another disorder. Estimates of psychotic symptoms in bipolar disorder, particularly during a manic episode, are ≥50% by clinical assessment and even higher by individual reports. Thus, antipsychotics are frequently used: as first treatment for psychosis not recognized as bipolar disorder, and as an adjunct to a mood-stabilizing agent in bipolars with psychotic symptoms.Most recently, antipsychotics have been examined for their mood-stabilizing properties as well (Slide 9). One may conceptualize using a selective serotonin reuptake inhibitor (SSRI) antidepressant for disorders such as panic disorder or obsessive-compulsive disorder, and using an antiepileptic as a mood-stabilizing agent; however, it is more difficult to accept that an agent approved for treatment of psychosis can be a primary therapy for bipolar disorder. Data from the monotherapy trials suggest that second-generation antipsychotics (SGAs) are at least as effective as lithium and valproic acid for acute mania. There is a very large database indicating that SGAs can be utilized as monotherapy for acute mania. However, there is limited data on the role of these agents in prevention of relapse and recurrence and in their efficacy for depression in the context of bipolar disorder. More studies will be needed to clarify whether SGAs should be used as monotherapy or whether they would be best used as augmenting agents in severe and psychotically manic or depressed patients.

Potential Misdiagnosis of Bipolar Disorder

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
D. Correia ◽  
L. Correia ◽  
T. Gandra ◽  
F. Silva
Keyword(s):  
Bipolar Disorder ◽  
Seasonal Pattern ◽  
Large Fraction ◽  
Review Literature ◽  
Mood Stabilizers ◽  
Psychotic Symptoms ◽  
Obsessive Compulsive ◽  
Clinical Indicators ◽  
Compulsive Disorder

Background:Several reports indicate that Bipolar Disorder (BD) is frequently underdiagnosedleading to overuse of antidepressants and underuse of mood stabilizers.Aims and methods:The aim is to review literature concerning this subject published since 2000.Results:BD seems to be frequently underdiagnosed. Several studies, as EPIDEP and NEMESIS, reveal insufficiencies on the diagnosis of this disorder, suggesting that clinicians miss this diagnosis about half of the times, and that about three quarters of these patients are not receiving appropriate treatment, respectively.BD is often misdiagnosed as Major Depression Disorder (MDD), with approximately 40% of BD patients being initially diagnosed as MDD. On the other hand, a large fraction of patients initially diagnosed as MDD will change diagnosis to BD during follow-up, with some authors presenting values as high as 67%. Studies comparing the depressive features of MDD and BD point to some strong clinical indicators of bipolarity in patients presenting with depression, such as family history, seasonal pattern, postpartum onset, psychotic symptoms, younger age, suicidal behaviours, among others.To a lesser extent, BD can also be misdiagnosed as: substance abuse, borderline personality, obsessive-compulsive disorder, among others.It is also important to consider that a large fraction of patients with BD diagnosis will change diagnosis during the follow-up period.Conclusion:BD patients with the diagnosis may represent only a fraction of the subjects with this disorder, and the true epidemiological extent of this problem needs further investigation.

Benefit of Clomipramine-quetiapine Combination in Obsessive-compulsive Disorder with Non Response to Serotonin Selective Reuptake Inhibitors. Case Report

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
G. Marian ◽  
B. Ionescu ◽  
D. Ghinea ◽  
N. Alina
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Rating Scale ◽  
Case Series ◽  
Antidepressant Medication ◽  
Tricyclic Antidepressant ◽  
Psychotic Symptoms ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Work Related ◽  
Affective Symptoms

Background:Patients who suffer of obsessive-compulsive disorder (OCD) experience obsessive thoughts and/or urges to engage in compulsive behaviours. the condition causes severe discomfort and, in many cases, leads to serious impairment in social and work-related functioning.Although antipsychotic monotherapy has been associated with ineffectiveness and even increase of psychotic symptoms (especially in psychotic patients), antipsychotics as adjuvant to antidepressant medication have proven to be effective in several case series and pilot clinical trials.The objective of this case was to evaluate the effectiveness of clomipramine-quetiapine combination in OCD refractory to serotonin selective reuptake inhibitors treatment patient.Method:23 years unemployed male was diagnosed with OCD after 1 year from onset and received 3 trials with serotonin selective reuptake inhibitors at therapeutical doses, without any improvement and even more with worsening of affective associated symptoms. We managed this case by using a tricyclic antidepressant (clomipramine up to 100 mg/day) with an atypical antipsychotic (quetiapine up to 200 mg/day). We employed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Obsessive-Compulsive Checklist (OCC) and Hamilton Depression rating Scale (HDRS) at baseline, weekly for the first 2 months and monthly after (follow up 2 years).Results:Patient achieved a very fast and sustained improvement both in obsessive-compulsive and affective symptoms, which provided a very good social and work rehabilitation.Conclusion:Clomipramine-quetiapine combination may be a benefit for OCD refractory to serotonin selective reuptake inhibitors and a safe strategy.

An Approach to Comorbidity Between Obsessive-Compulsive Disorder and Schizophrenia

2016 ◽  
Vol 33 (S1) ◽  
pp. S495-S495
Author(s):  
A. Gomez Peinado ◽  
S. Cañas Fraile ◽  
P. Cano Ruiz
Keyword(s):  
Mental Health ◽  
Obsessive Compulsive Disorder ◽  
Negative Symptoms ◽  
Behavioral Therapy ◽  
Psychotic Symptoms ◽  
Simultaneous Presence ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Salud Mental ◽  
Competing Interest

IntroductionAn association has been observed between obsessive symptoms in Obsessive Compulsive Disorder (OCD) and psychotic symptoms in schizophrenia, being sometimes difficult to establish a clear limit between them. The term “schizo-obsessive disorder” was proposed to describe the resulting disorder of comorbidity of OCD and schizophrenia, although it has not been definitely settled.ObjectiveTo analyze the incidence of coexistence of OCD and schizophrenia symptoms and the way it modifies the treatment and prognosis of the illness.MethodReview of some articles published in Mental Health journals such as “Salud Mental” and “Actas Españolas de Psiquiatría”.ResultsSome studies about psychotic patients have determined 15% as the average of comorbidity of OCD and schizophrenia. The probability of having OCD is six times bigger if there is psychotic pathology associated.The fact that obsessive and psychotic symptoms get together in some patients shades the prognosis bringing more negative symptoms, more depressive humor, a larger cognitive impairment, more resistance to treatment and more relapses than we can observe in OCD and schizophrenia isolated.The pharmacological treatment usually consists in neuroleptic plus anti-obsessive drugs, together with cognitive-behavioral therapy. Sometimes, when there is a very bad evolution, it is required to consider psychosurgery as one necessary option, even though its use in this context is not much widespread.ConclusionsThe simultaneous presence of OCD and schizophrenia is more common than we could expect only by chance and makes the prognosis worse, being difficult to find a truly effective treatment.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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