Comparing the effect of cardiac biomarkers on the outcome of normotensive patients with acute pulmonary embolism

Acute pulmonary embolism (PE) is a cardiovascular challenge with potentially fatal consequences. This study was designed to observe the association of novel cardiac biomarkers with outcome in this setting. In this prospective study, from 86 patients with a confirmed diagnosis of PE, 59 patients met the inclusion criteria (22 men, 37 women; mean age, 63.36±15.04 y).The plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP), growth differentiation factor-15 (GDF-15), heart-type fatty acid-binding protein (H-FABP), tenascin-C, and D-dimer were measured at the time of confirmed diagnosis. The endpoints of the study were defined as the short-term adverse outcome and long-term all-cause mortality. Totally, 11.8% (7/59) of the patients had the short-term adverse outcome. The mean value of logNT-proBNP was 6.40±1.66 pg/ml. Among all the examined biomarkers, only the mean value of logNT-proBNP was significantly higher in the patients with the short-term adverse outcome (7.88±0.67 vs. 6.22± 1.66 pg/ml; OR, 2.359; 95% CI, 1.037 to 5.367; P=0.041). After adjustment, a threefold increase in the short-term adverse outcome was identified (OR, 3.239; 95% CI, 0.877 to 11.967; P=0.078).Overall, 18.64% (11/59) of the patients had expired by the long-term follow-up. Moreover, adjustment revealed an evidence regarding association between increased logNT-proBNP levels and long-term mortality (HR, 2.163; 95%CI, 0.910 to 5.142; P=0.081). Our study could find evidences on association between increased level of NT-proBNP and short-term adverse outcome and/or long-term mortality in PE. This biomarker may be capable of improving prediction of outcome and clinical care in non-high-risk PE.

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764 Elevated cardiac troponin I levels in acute pulmonary embolism predict increased long-term mortality

European Heart Journal ◽

10.1016/s0195-668x(03)94166-2 ◽

2003 ◽

Vol 24 (5) ◽

pp. 138 ◽

Cited By ~ 1

Author(s):

J SALLACH

Keyword(s):

Pulmonary Embolism ◽

Cardiac Troponin ◽

Acute Pulmonary Embolism ◽

Troponin I ◽

Cardiac Troponin I ◽

Long Term Mortality

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Fragmented QRS Complex Predicts In-Hospital Adverse Events and Long-Term Mortality in Patients with Acute Pulmonary Embolism

Annals of Noninvasive Electrocardiology ◽

10.1111/anec.12332 ◽

2015 ◽

Vol 21 (5) ◽

pp. 470-478 ◽

Cited By ~ 3

Author(s):

Mehmet Serkan Cetin ◽

Elif Hande Ozcan Cetin ◽

Fazil Arisoy ◽

Mevlüt Serdar Kuyumcu ◽

Serkan Topaloglu ◽

...

Keyword(s):

Pulmonary Embolism ◽

Adverse Events ◽

Acute Pulmonary Embolism ◽

Qrs Complex ◽

Fragmented Qrs ◽

Long Term Mortality

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Short- and Long-term Mortality Risk After Acute Pulmonary Embolism

Current Cardiology Reports ◽

10.1007/s11886-018-1084-6 ◽

2018 ◽

Vol 20 (12) ◽

Cited By ~ 4

Author(s):

Rajesh Gupta ◽

Dylan D. Fortman ◽

Daniel R. Morgenstern ◽

Christopher J. Cooper

Keyword(s):

Pulmonary Embolism ◽

Mortality Risk ◽

Acute Pulmonary Embolism ◽

Short And Long Term ◽

Long Term Mortality

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Reply to letter to the editor: ‘’Predicting long-term mortality after acute pulmonary embolism: One issue, multiple faces’’

10.5152/anatoljcardiol.2022.l1 ◽

2022 ◽

Vol 26 (1) ◽

pp. 77-78

Author(s):

Abdulsamet Sandal ◽

◽

Elif Tuğçe Korkmaz ◽

Funda Aksu ◽

Deniz Köksal ◽

...

Keyword(s):

Pulmonary Embolism ◽

Acute Pulmonary Embolism ◽

Letter To The Editor ◽

Long Term Mortality

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A SLR Pre-Processing Algorithm Based on Satellite Signature Effect

Applied Sciences ◽

10.3390/app11198880 ◽

2021 ◽

Vol 11 (19) ◽

pp. 8880

Author(s):

Bowen Guan ◽

Cunbo Fan ◽

Ning An ◽

Ricardo Cesar Podesta ◽

Dra Ana Pacheco ◽

...

Keyword(s):

Mean Value ◽

Observation Data ◽

Short Term ◽

Error Sources ◽

Effect Model ◽

The Mean ◽

The Stability ◽

First Time ◽

Satellite Signature Effect

As one of the major error sources, satellite signature effect should be reduced or even erased from the distribution of the post-fit residuals to improve the ranging precision. A simulation of satellite signature effect removal process for normal point algorithm is conducted based on a revised model of satellite response, which fully considers the structural and distribution characteristics of retroreflectors. In order to eliminate both long-term and short-term satellite signature effect, a clipping method for SLR data processing is proposed by defining the clipping location as 5.6 mm away from the mean value of the long-term fit residuals to select effective returns for normal points. The results indicate that, compared to normal points algorithm, the RMS per NP of LAGEOS-1 observation data processed by the clipping method is reduced from 62.90 ± 9.9 mm to 56.07 ± 4.69 mm, and the stability of RMS is improved 53%. This study improves the satellite signature effect model and simulates the fluctuation of normal points caused by satellite signature effect for the first time. The new method based on the simulation of satellite signature effect has stronger robustness and applicability, which can further minimize the influence of satellite signature effect on the SLR production and significantly improve the data property.

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Performance of pulmonary embolism severity index in predicting long-term mortality after acute pulmonary embolism

10.5152/anatoljcardiol.2021.99345 ◽

2021 ◽

Vol 25 (8) ◽

pp. 544-554

Author(s):

Abdulsamet Sandal ◽

◽

Elif Tugce Korkmaz ◽

Funda Aksu ◽

Deniz Koksal ◽

...

Keyword(s):

Pulmonary Embolism ◽

Acute Pulmonary Embolism ◽

Severity Index ◽

Long Term Mortality

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Abstract 18183: Short-term Impact of Defibrillation Testing on Heart Failure Admission

Circulation ◽

10.1161/circ.132.suppl_3.18183 ◽

2015 ◽

Vol 132 (suppl_3) ◽

Author(s):

Baris Akdemir ◽

Balaji Krishnan ◽

Venkatakrishna Tholakanahalli ◽

David Benditt ◽

Jian-Ming Li

Keyword(s):

Heart Failure ◽

Retrospective Study ◽

Short Term ◽

Primary Endpoints ◽

Significant Difference ◽

Heart Failure Admission ◽

The Mean ◽

Demographic Features ◽

Long Term Mortality

Introduction: SIMPLE trial showed that defibrillation testing (DT) is safe but does not improve shock efficacy or mortality. However, impact of DT on heart failure (HF) admission at 30 days is unclear. Objectives: The aim of this study was to compare mortality and HF admission of ICD recipients who underwent DT (DT+) compared with those who did not (DT-). Methods: In this retrospective study, we analyzed consecutive patients who received an ICD ( new implant or generator change ) with DT+ and DT- between January 2008 and May 2014 from our ICD registry. Primary endpoints were death ( 30 days and 1 year ) and HF admission ( 30 days) . Results: Of the 501 patients, 311 patients (62,1%) were in DT+ group vs 190 (37,9%) were in DT- group. The mean ages in DT+ and DT- were 66 ± 10 and 70 ± 10 respectively (p<0.0001). DT- group had more generator change than DT+ group ( 61,1% versus 30,9%, p < 0.0001). Other demographic features were not significantly different between two groups (Table 1). No significant difference in mortality was found between two groups at 30 days and 1 year. HF admission at 30 days was significantly higher in DT+ group than in DT- group ( 17,4 % versus 4,7%, p < 0.0001) (Table 2). Conclusion: No short-term and long-term mortality were associated with DT, but DT was associated with increased HF admission at 30 days. Future prospective studies are needed to prove this association.

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