Helicobacter Pylori in periodontal pockets of chronic periodontitis patients with and without type II diabetes mellitus: a randomized controlled trial

This randomized controlled study evaluated the association of Helicobacter pylori (H. pylori) with chronic periodontitis patients with and without type II Diabetes Mellitus. H. pylori is considered to be a pathogen responsible for gastritis, peptic ulcers and a risk factor for gastric cancer. The aim of the present study was to evaluate the association of H. pylori with chronic periodontitis patients with and without type II diabetes mellitus before and after treatment. The prevalence of H. pylori in periodontal pockets was determined by rapid urease test in a 36 patients, which were grouped as Group 1 (Healthy subjects), Group II (chronic periodontitis patients) and Group III (Chronic periodontitis patients with Type II Diabetes Mellitus), 12 in each group before treatment by collecting plaque samples. After treatment, 12 plaque samples were collected and prevalence H. pylori was detected. Group II and Group III had a significantly higher rate of positive results for H. pylori compared to healthy subjects before treatment. After treatment, H. pylori were not detected in Group II and in Group III Only one of 12 chronic periodontitis patients with Type II diabetes mellitus had H. pylori in the periodontal pocket. The prevalence of H. pylori did not differ significantly between the chronic periodontitis patients with and without type II diabetes mellitus. Meticulous scaling and root planning will reduce the prevalence of H. pylori in periodontal pockets.

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Histological Effect of Smoking on Gingiva of Patients with Type II Diabetes Mellitus and Chronic Periodontitis: A Randomized Controlled Trial

10.46889/jdhor.2020.1201 ◽

2020 ◽

Vol 01 (02) ◽

Author(s):

Esha Yadav ◽

Rudrakshi Chickanna ◽

Prabhuji MLV

Keyword(s):

Diabetes Mellitus ◽

Randomized Controlled Trial ◽

Chronic Periodontitis ◽

Type Ii Diabetes ◽

Controlled Trial ◽

Type Ii Diabetes Mellitus ◽

Type Ii ◽

Randomized Controlled ◽

Histological Effect

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Role of Apo B and Apo A1 Levels in Relation to Conventional Lipid Profile in Patients of Ischaemic Heart Disease with or without Type II Diabetes Mellitus

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/50956.15611 ◽

2021 ◽

Author(s):

Hardik N Javia ◽

Milav H Bhavsar ◽

Bhavesh R Sadariya ◽

Amitkumar V Maheshwari ◽

Hariom Sharma

Keyword(s):

Diabetes Mellitus ◽

Lipid Profile ◽

Type Ii Diabetes ◽

Type Ii Diabetes Mellitus ◽

P Value ◽

Type Ii ◽

Apo B ◽

Group Iii ◽

Group I ◽

Group Ii

Introduction: Ischaemic Heart Disease (IHD) or Coronary Artery Disease (CAD) is the most prevalent chronic disease and the main leading cause of death in the world, with more than half a million newly diagnosed IHD patients each year. Central to this are disorders of lipoprotein metabolism. Apolipoprotein B (Apo B) and Apolipoprotein A1 (Apo A1) are structural and functional components of lipoprotein particles that serve as transporters of cholesterol. Apo B and Apo A1 are among the emerging markers for Cardiovascular Diseases (CVD). Routine conventional lipid profile does not incorporate these markers. Aim: To determine the level of Apo A1 and Apo B in patients of IHD with or without Type II Diabetes Mellitus (T2DM) and analyse the significance of these parameters over the conventional lipid profile. Materials and Methods: The case-control study was conducted at Government Medical College, Bhavnagar, Gujarat, India from July 2013 to December 2013. The study consists of 100 participants including 50 having IHD only (Group I), 50 having IHD with T2DM (Group II) as study groups and 50 healthy individuals (Group III) as control. Various biochemical parameters including Apo B and Apo A1 were analysed and statistically evaluated to come to conclusion. Results: The demographic details of the participants which shows no significant different in age and gender among groups I, II and III. Apo B and A1 were elevated in group I and II and were found highly significant (p-value <0.0001) as compared to the group III. There was positive correlation of serum Apo B levels with total cholesterol (r=0.495, p-value <0.0001), Low-Density Lipoproteins (LDL-C) (r=0.526, p-value <0.0001) and Apo A1 (r=0.685, p-value <0.0001) in group I and LDL-C (r=0.468, p-value=0.001) and Apo A1 (r=0.754, p-value <0.0001) in group II. Similarly, Apo A1 levels were positively correlated with Apo B (r=0.685, p<0.0001) in group I and LDL-C (r=0.305, p-value=0.031) and Apo B (r=0.754, p-value <0.0001) in group II. Conclusion: As the Apo B and Apo A1 cover both atherogenic and antiatherogenic lipid parameters respectively, it can be used as a better predictor of development of IHD with and without T2DM in comparison to conventional parameters of lipid profile.

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SALIVARY PARAMETERS IN DIABETICS TYPE II WITH SEVERE CHRONIC PERIODONTITIS

Brazilian Journal of Medicine and Human Health ◽

10.17267/2317-3386bjmhh.v1i2.246 ◽

2013 ◽

Vol 1 (2) ◽

Author(s):

Júlia Dias Magalhães ◽

Camila Barreto dos Santos Tolomei ◽

Roberta Santos Tunes ◽

Urbino da Rocha Tunes ◽

Márcia Tosta Xavier

Keyword(s):

Diabetes Mellitus ◽

Chronic Periodontitis ◽

Type Ii Diabetes ◽

Dental Health ◽

Salivary Flow ◽

Type Ii Diabetes Mellitus ◽

Buffering Capacity ◽

Type Ii ◽

Commercial Kits ◽

Systemic Condition

Periodontitis and diabetes mellitus combine systemic condition and dental health and can cause salivary alterations. This work examined the saliva of 16 individuals with type II diabetes mellitus (DM) and severe chronic periodontitis (SCP) (G1), 11 with DM and without SCP (G2), 14 without DM with SCP (G3) and 15 without DM and without SCP (G4). The periodontal condition was evaluated, salivary flow and buffering capacity were analyzed and salivary components were measured using commercial kits. Diabetics with SCP showed a tendency to decrease the flow. The buffering capacity remains unchanged. Urea (p < 0.018) and total protein (p < 0.001) were larger and less Calcium was observed (p < 0.0001) in diabetics. In patients with SCP, the DM favored even greater urea increase. The phosphate increased in groups G1, G2 and G3 (p < 0.0001) compared to G4. The metabolism from diabetics with SCP increases salivary proteins, increasing urea resulting from amino acids degradation by periodontal bacterias.

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