Multiple logistic regression analysis of risk factors in elderly pneumonia patients: QTc interval prolongation as a prognostic factor

Background: Acute pneumonia is a serious problem in the elderly and various risk factors have already been reported, but the involvement of QTc interval prolongation remains uncertain. The aim of this study was to elucidate the prognostic factors for the development of pneumonia in elderly patients and to study the possible involvement of QTc interval prolongation. Methods: The subjects were 249 hospitalized pneumonia patients more than 65 years old in Aki-Ohta Hospital from January 2010 to December 2013. Community-acquired pneumonia patients and nursing care and healthcare-associated pneumonia patients were included in the study. The pneumonia severity index, vital signs, blood chemistry data and ECG findings were retrospectively compared using multiple logistic regression analysis. Results: 39 patients died within 30 days from onset. The clinical features related to poor prognosis were: advanced age, past history of cerebral vascular disease and/or diabetes mellitus, decreased serum albumin level, higher CURB-65 or PORT index scores and QTc interval prolongation. Patients showing a prolonged QTc interval had a higher mortality than those with a normal QTc interval. A prolonged QTc interval was not related to serum calcium concentration and/or treatment with QTc prolongation drug, clarithromycin or azithromycin, but related to age, lower albumin concentration and past history of diabetes mellitus. Conclusions: These findings suggest potential prognostic factors for pneumonia in elderly patients, including a prolonged QTc interval (> 0.44 seconds).

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Multiple logistic regression analysis of risk factors in elderly pneumonia patients: QTc interval prolongation as a prognostic factor

Multidisciplinary Respiratory Medicine ◽

10.1186/2049-6958-9-59 ◽

2014 ◽

Vol 9 (1) ◽

Cited By ~ 2

Author(s):

Yasuyuki Taooka ◽

Gen Takezawa ◽

Miki Ohe ◽

Akihisa Sutani ◽

Takeshi Isobe

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Prognostic Factor ◽

Logistic Regression Analysis ◽

Multiple Logistic Regression Analysis ◽

Qtc Interval ◽

Multiple Logistic Regression ◽

Interval Prolongation ◽

Qtc Interval Prolongation

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A Unique Case Presentation of Methadone Toxicity without QTc Interval Prolongation despite Patient Risk Factors

Clinical Studies & Medical Case Reports ◽

10.24966/csmc-8801/100057 ◽

2018 ◽

Vol 5 (3) ◽

pp. 1-6

Author(s):

Keith T Veltri ◽

Keyword(s):

Risk Factors ◽

Qtc Interval ◽

Interval Prolongation ◽

Unique Case ◽

Patient Risk ◽

Case Presentation ◽

Qtc Interval Prolongation

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Meperidine-induced QTc-interval prolongation: prevalence, risk factors, and correlation to plasma drug and metabolite concentrations

International Journal of Clinical Pharmacology and Therapeutics ◽

10.5414/cp202612 ◽

2017 ◽

Vol 55 (03) ◽

pp. 275-285 ◽

Cited By ~ 8

Author(s):

Guillermo Alberto Keller ◽

María Cedilia Villa Etchegoyen ◽

Nicolás Fernández ◽

Nancy Mónica Olivera ◽

Patricia Noemi Quiroga ◽

...

Keyword(s):

Risk Factors ◽

Qtc Interval ◽

Plasma Drug ◽

Interval Prolongation ◽

Qtc Interval Prolongation ◽

Metabolite Concentrations

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Association of the location and initial degree of malignant central airway stenosis with the risk of severe restenosis after interventional bronchoscopy

BMC Pulmonary Medicine ◽

10.1186/s12890-021-01690-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Saibin Wang ◽

Renzhi Zhou ◽

Siyao Zhu ◽

Dan Yan

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Main Bronchus ◽

Multiple Logistic Regression Analysis ◽

Left Main Bronchus ◽

Multiple Logistic Regression ◽

Left Main ◽

Initial Degree ◽

Central Airway

Abstract Background Therapeutic bronchoscopy is one of the effective methods in the treatment and management of malignant central airway stenosis (MCAS). However, restenosis after therapeutic bronchoscopy frequently occurs and severe restenosis (SR) can be life-threatening. Therefore, this study aimed at investigating the risk factors for SR after therapeutic bronchoscopy. Methods The data of 233 consecutive cases with MCAS who were subjected to therapeutic bronchoscopy between 2015 and 2020 at a tertiary hospital were collected. Patients were divided into SR group and non-SR during 6 months after therapeutic bronchoscopy. Multiple logistic regression analysis was performed to determine the risk factors for SR. Results SR during 6 months after therapeutic bronchoscopy occurred in 39.5% (92/233) of patients. The location and the initial degree of MCAS were associated with SR, as assessed by multiple logistic regression analysis (P < 0.05). The risk of SR after therapeutic bronchoscopy in the left main bronchus, right main bronchus, and right intermediate bronchus increased, compared to the risk when of MCAS was located in the trachea (OR (95% CI) of 8.821 (1.850-25.148), 6.583 (1.791–24.189), and 3.350 (0.831–13.511), respectively). In addition, the initial degree of MCAS was positively associated with an increased risk of SR (OR 1.020; 95% CI 1.006–1.035). Conclusions MCAS located in the left main bronchus, right main bronchus and right intermediate bronchus, as well as the higher initial degree of MCAS were independent risk factors for SR during 6 months after therapeutic bronchoscopy.

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Cardiovascular Risk Factors in Pre-dialysis Chronic Kidney Disease patients of Nepal

Journal of Advances in Internal Medicine ◽

10.3126/jaim.v9i2.32813 ◽

2020 ◽

Vol 9 (2) ◽

pp. 47-53

Author(s):

Kashyap Dahal ◽

A. Baral ◽

K.K. Sah ◽

J.R. Shrestha ◽

A. Niraula ◽

...

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Logistic Regression ◽

Regression Analysis ◽

Kidney Disease ◽

Multiple Logistic Regression Analysis ◽

Multiple Logistic Regression ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Traditional Risk Factors

Background and Aims: Cardiovascular disease (CVD) is the commonest cause of morbidity and mortality in patients with chronic kidney disease (CKD) due to increased prevalence of traditional and nontraditional CVD risk factors. Our study aimed to evaluate these risk factors in pre-dialysis Nepalese CKD patients. Methods: This was a cross-sectional study conducted in Department of Nephrology, Bir hospital. Total 100 consecutive pre-dialysis CKD patients were enrolled. Ten traditional and six nontraditional CVD risk factors were analyzed and compared between CKD stages. Descriptive statistics was used to illustrate the socio-demographic and clinical characteristics, chi square test for categorical variables and multiple logistic regression analysis was done to determine the risk factors of CVD in CKD patients. p-value<0.05 was considered to be statistically significant. Results: Mean patient age was 52.03}13.64 years with majority (60%) of the patients being male. Comparison of traditional risk factors in different stages depicted similar trend except for old age in Stage 3 CKD (p=0.002). Anemia (p<0.001), hyperphosphatemia (p=0.01), hyperparathyroidism (p<0.01) and cumulative nontraditional risk factors were significantly higher (p=0.01) in stage 5 CKD. The predicted CVD events by Framingham risk score showed high risk in 37% with no significant difference among the stages. Multiple logistic regression analysis showed increased body mass index, low serum albumin and increased serum phosphate as the three significant predictors for left ventricular hypertrophy. Conclusion: Our study shows that the CVD risk factors were prevailing along the various stages of CKD. The occurrence of non-traditional risk factors increased with increasing stage of CKD.

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Changes In QTc Interval Duration Among Heroin Addicts On Methadone Treatment

Serbian Journal of Experimental and Clinical Research ◽

10.1515/sjecr-2015-0029 ◽

2015 ◽

Vol 16 (3) ◽

pp. 217-228

Author(s):

Mirjana Jovanovic ◽

Mladen Divnic ◽

Milan Jovanovic ◽

Sasa Babic ◽

Katarina Nikic Djuricic ◽

...

Keyword(s):

Risk Factors ◽

Illicit Drugs ◽

Methadone Treatment ◽

Torsade De Pointes ◽

Diagnostic Methods ◽

Qtc Interval ◽

Interval Prolongation ◽

Safety Level ◽

Co Morbidity ◽

Qtc Interval Prolongation

AbstractThis paper aimed to collect and unite facts known about the effect of methadone treatment on QTc interval prolongation that could determine precipitating factors in the development of heart arrhythmias and their consequences (Torsade de Pointes and sudden cardiac death), and to raise the methadone treatment safety level.Studies conducted up to now clearly demonstrate that methadone therapy evokes changes in the heart’s electrical conduction, but those studies also show that QTc interval prolongation could be precipitated by other factors. The most often present risk factors in our research were dose of methadone, co-medication, and co-morbidity, but other relevant risk factors were gender, age, misuse of illicit drugs, therapy length and tobacco use.Active participation in modern treatment processes and implementation of knowledge acquired recently into daily practice, such as setting up reutilized questionnaires and diagnostic methods to expose higher risk for complications and providing broader therapeutic range for cases of drug replacement necessity, will enhance therapy safety level and bring us to the next step of resocialization of these patients, which needs to remain the final goal of treatment.

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