Functional gastrointestinal disorders in newborns: nutritional perspectives

Diagnostic Process ◽

Evidence Based ◽

Caregiver Distress ◽

Evidence Based Treatments ◽

History Of ◽

Rome Iv

Functional gastrointestinal disorders (FGIDs) definition in children has changed over the years trying to facilitate clinicians, because the diagnostic process is complicated by the interpretation variability of symptoms described by children or by their caregivers for newborns and toddlers. This review refers to the Rome IV classification system, drafted in 2016. FGIDs pathophysiology is multifactorial and still poor understood, with limitations for the therapeutic process, which results often in unnecessary and alternative treatments trying to reduce the relevant caregiver distress, but with increased costs for families and for the National Health Service. This study reports the most recent evidence-based treatments for FGIDs in newborns: though in most cases the first action is an educational and behavioral intervention, reassuring caregivers about the transient and self-limiting natural history of FGIDs, there is now more evidence to recommend probiotics in some infant FGIDs.

Update on Evidence-Based Treatments for Caregiver Distress

PsycEXTRA Dataset ◽

10.1037/e618422013-001 ◽

2013 ◽

Author(s):

Dolores Gallagher-Thompson ◽

David Coon

Keyword(s):

Evidence Based ◽

Caregiver Distress ◽

Evidence Based Treatments

Functional gastrointestinal disorders in children: agreement between Rome III and Rome IV diagnoses

European Journal of Pediatrics ◽

10.1007/s00431-021-04013-2 ◽

2021 ◽

Author(s):

Desiree F. Baaleman ◽

Carlos A. Velasco-Benítez ◽

Laura M. Méndez-Guzmán ◽

Marc A. Benninga ◽

Miguel Saps

Keyword(s):

Diagnostic Criteria ◽

Functional Dyspepsia ◽

Functional Constipation ◽

Final Analysis ◽

Rome Iii ◽

Sample Characteristics ◽

Irritable Bowel ◽

Rome Iv

AbstractTo evaluate the agreement between the Rome III and Rome IV criteria in diagnosing pediatric functional gastrointestinal disorders (FGIDs), we conducted a prospective cohort study in a public school in Cali, Colombia. Children and adolescents between 11 and 18 years of age were given the Spanish version of the Questionnaire on Pediatric Functional Gastrointestinal Disorders Rome III version on day 0 and Rome IV version on day 2 (48 h later). The study protocol was completed by 135 children. Thirty-nine (28.9%) children were excluded because of not following the instructions of the questionnaire. The final analysis included data of 96 children (mean 15.2 years old, SD ± 1.7, 54% girls). Less children fulfilled the criteria for an FGID according to Rome IV compared to Rome III (40.6% vs 29.2%, p=0.063) resulting in a minimal agreement between the two criteria in diagnosing an FGID (kappa 0.34, agreement of 70%). The prevalence of functional constipation according to Rome IV was significantly lower compared to Rome III (13.5% vs 31.3%, p<0.001), whereas functional dyspepsia had a higher prevalence according to Rome IV than Rome III (11.5% vs 0%).Conclusion: We found an overall minimal agreement in diagnosing FGIDs according to Rome III and Rome IV criteria. This may be partly explained by the differences in diagnostic criteria. However, limitations with the use of questionnaires to measure prevalence have to be taken into account. What is Known:• The Rome IV criteria replaced the previous Rome III criteria providing updated criteria to diagnose functional gastrointestinal disorders (FGIDs).• Differences found between Rome IV and historic Rome III FGID prevalence may have been affected by changes in prevalence over time or differences in sample characteristics. What is New:• We found a minimal agreement between Rome III and Rome IV FGID diagnosis, especially in the diagnoses of functional constipation, irritable bowel syndrome, and functional dyspepsia.• The minimal agreement may be partly explained by changes in diagnostic criteria, but limitations with the use of questionnaires to measure prevalence have to be taken into account.

Prevalence of functional gastrointestinal disorders in infants and young children in China

BMC Pediatrics ◽

10.1186/s12887-021-02610-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ying Huang ◽

Serene Yaling Tan ◽

Panam Parikh ◽

Vanitha Buthmanaban ◽

Shaman Rajindrajith ◽

...

Keyword(s):

Young Children ◽

Maternal Education ◽

Gastrointestinal Symptoms ◽

Functional Constipation ◽

Cross Sectional ◽

Validated Questionnaire ◽

Rome Iv ◽

Infants And Young Children

Abstract Background The prevalence of functional gastrointestinal disorders (FGIDs) in children, particularly from Asia, is largely unknown. There are not many studies done in Asia especially using the Rome IV criteria. The aim of this study is to assess the prevalence of FGIDs in infants and young children in a representative sample in China. Methods A prospective, cross-sectional, community-based survey was conducted among healthy infants and young children between the ages of 0–4 years in Jinhua and Shanghai, China. A total of 2604 subjects (1300 subjects from Jinhua and 1304 subjects from Shanghai) completed a validated questionnaire on pediatric gastrointestinal symptoms. FGIDs in infants and young children were diagnosed using the Rome IV criteria. Results According to the Rome IV criteria, the prevalence of having a FGID in Chinese infants and young children is 27.3%. Infant regurgitation (33.9%) was the most common FGID among the 0–6 months old while functional constipation (7.0%) was the most common among the 1–4 years old. Risk factor analysis revealed that prevalence of infantile colic was higher with better maternal education and low birth weight. Prevalence of infantile regurgitation was significantly greater in males, living in a rural area, being exclusively breast fed at least up to 4 months and starting formula feeds within the first month. The risk of functional constipation was lower for infants who were delivered vaginally. Conclusions Infantile regurgitation was the most common FGID in Chinese infants while functional constipation was most prevalent among young Chinese children. Trial registration Netherlands Trial Registry Identifier: NL6973/NTR7161.

Natural History of Functional Gastrointestinal Disorders: A 12-year Longitudinal Population-Based Study

Gastroenterology ◽

10.1053/j.gastro.2007.06.010 ◽

2007 ◽

Vol 133 (3) ◽

pp. 799-807.e1 ◽

Cited By ~ 186

Author(s):

Smita L.S. Halder ◽

G. Richard Locke ◽

Cathy D. Schleck ◽

Alan R. Zinsmeister ◽

L. Joseph Melton ◽

...

Keyword(s):

Natural History ◽

Population Based ◽

Population Based Study ◽

History Of

Functional Gastrointestinal Disorders in Mediterranean countries according to Rome IV criteria

Journal of Pediatric Gastroenterology and Nutrition ◽

10.1097/mpg.0000000000003358 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

C. Strisciuglio ◽

S. Cenni ◽

M.R. Serra ◽

P. Dolce ◽

S. Kolacek ◽

...

Keyword(s):

Mediterranean Countries ◽

Rome Iv

Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria

The Journal of Pediatrics ◽

10.1016/j.jpeds.2017.12.012 ◽

2018 ◽

Vol 195 ◽

pp. 134-139 ◽

Cited By ~ 64

Author(s):

Samantha G. Robin ◽

Catherine Keller ◽

Russell Zwiener ◽

Paul E. Hyman ◽

Samuel Nurko ◽

...

Keyword(s):

Rome Iv

Case–control study on generalised joint hypermobility in schoolchildren with functional gastrointestinal disorders according to Rome IV criteria in Spanish

Anales de Pediatría (English Edition) ◽

10.1016/j.anpede.2019.04.010 ◽

2019 ◽

Vol 91 (6) ◽

pp. 401-407

Author(s):

Carlos Alberto Velasco-Benítez ◽

Ángeles Ruiz-Extremera ◽

Miguel Saps

Keyword(s):

Case Control Study ◽

Case Control ◽

Joint Hypermobility ◽

Control Study ◽

Rome Iv

Functional Gastrointestinal Disorders in Outpatients Aged up to 12 Months: A French Non-Interventional Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17114031 ◽

2020 ◽

Vol 17 (11) ◽

pp. 4031

Author(s):

Florence Campeotto ◽

Marie-Odile Barbaza ◽

Veronique Hospital

Keyword(s):

High Frequency ◽

Specific Treatment ◽

Maternity Hospital ◽

Cow’S Milk ◽

Cross Sectional ◽

Cow's Milk ◽

New Information ◽

Rome Iv

Background: The aim of this study was to estimate the frequency of functional gastrointestinal disorders (FGIDs) in infants aged up to 12 months according to the new ROME IV criteria defining these disorders, and to describe the management of FGIDs in France. Methods: This French non-interventional, cross-sectional, and multicenter study was conducted among private-outpatient physicians who each included four consecutive patients aged up to 12 months. The frequency of FGIDs was described using the ROME IV criteria versus clinicians’ diagnosis. The characteristics of infants with and without FGID were compared, and the management of the FGIDs was described. Results: In the 1722 infants analyzed, the following frequencies were observed according to the ROME IV criteria versus the physicians’ diagnosis: regurgitation 41% versus 45%; colic 18% versus 30%; constipation 9% versus 19%; diarrhea 3% versus 8%. Of note, FGID infants were less frequently exclusively breastfeeding at the maternity hospital (p < 0.001), were introduced to cow’s milk earlier after leaving the maternity hospital (p < 0.001), and more frequently had symptoms suggestive of cow’s milk protein allergy (p < 0.001). Physicians frequently recommended an adapted infant formula (in 77% to 82% of cases depending on the FGID diagnosed) and prescribed a specific treatment in 51% to 66% of infants (probiotics: 35% to 64%). Conclusions: This real-world study confirms the high frequency of FGIDs in infants in France, and provides new information regarding the characteristics of FGID infants.