Efficacy of Citalopram as a Monotherapy or as an Adjunctive Treatment to Estrogen Therapy for Perimenopausal and Postmenopausal Women With Depression and Vasomotor Symptoms

2003 ◽  
Vol 64 (4) ◽  
pp. 473-479 ◽  
Author(s):  
Claudio N. Soares ◽  
Jennifer R. Poitras ◽  
Jennifer Prouty ◽  
Allison B. Alexander ◽  
Jan L. Shifren ◽  
...  

Maturitas ◽  
2004 ◽  
Vol 48 (2) ◽  
pp. 97-105 ◽  
Author(s):  
Lotta Lindh-Åstrand ◽  
Elizabeth Nedstrand ◽  
Yvonne Wyon ◽  
Mats Hammar


2016 ◽  
Vol 18 (6) ◽  
pp. 14-19
Author(s):  
S.A. Levakov ◽  
◽  
E.I. Borovkova ◽  


GYNECOLOGY ◽  
2020 ◽  
Vol 22 (1) ◽  
pp. 50-54
Author(s):  
Zukhra Kh. Ebzieva ◽  
Svetlana V. Yureneva ◽  
Tatiana Yu. Ivanets

Aim. To conduct a comparative analysis of serum orexin A levels in women of different age periods with and without sleep disorder and vasomotor symptoms. To evaluate the dynamics of orexin A levels under menopausal hormone therapy. Materials and methods. The study included 50 postmenopausal women and 30 women of reproductive age with a regular menstrual cycle. Using block randomization, patients are divided into 3 groups: group 1 (main group), n=25, -STRAW+ 10 (+1b and +1c), patients with sleep disorder and vasomotor symptoms; group 2 (comparison group), n=25, STRAW+ 10 (+1b and +1c), patients with vasomotor symptoms without sleep disorder; group 3 (control group), n=30, STRAW+ 10 (-4), women of reproductive age without sleep disorder. Group 1 patients were given menopausal hormone therapy. A comparative analysis was carried out using the questionnaire for assessing menopausal symptoms severity by the Greene Scale (the Greene Climacteric Scale) and Rating Scale for subjective sleep characteristics. After 12 weeks of treatment, a control examination was performed. Results. In group 1 women, the serum orexin A levels were significantly higher compared to the women without the symptoms. The link between the orexin A levels and menopause syndrome severity was established. A significant decrease in the menopausal symptoms severity after 12 weeks of menopausal hormone therapy was shown. It was accompanied by a 1,3-fold decrease in orexin A levels. Conclusions. The obtained data indicate the possible role of orexin A and the orexin neuropeptide system in the pathogenesis of sleep disorder and vasomotor symptoms in postmenopausal women.





Author(s):  
Gloria A. Bachmann ◽  
Matthias Schaefers ◽  
Alkaz Uddin ◽  
Wulf H. Utian


2021 ◽  
Vol 9 (3) ◽  
pp. 10
Author(s):  
Jatinder Kumar Mokta ◽  
Kiran Kumar Mokta ◽  
Arjun Tandon ◽  
Renuka Pathania ◽  
Aniketa Sharma ◽  
...  

Background: Early surgical menopause increases risk of cardiovascular disease, osteoporosis, fracture, cognitive impairment and sexual dysfunction than women with late menopause. Estrogen therapy (ET) remains the most effective therapy for vasomotor symptoms related to surgically induced menopause. Meterials and Methods: It was a prospective cross-section study. Result: Amongst 255 symptomatic women, 163 (63.92%) women had severe vasomotor symptoms and 54 (33.12% of 163 women) of them had very incapacitating symptoms with marked reduction in their quality of life. 59 (23.13%) women had moderate symptoms with mild disturbances in their sleep while 33 (12.94%) women had only mild symptoms. Conclusion: It is agreed that women who undergo bilateral oophorectomy before the onset of natural menopause should be considered for estrogen therapy for the management of vasomotor symptoms until the average age of natural menopause.



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