Non-hormonal correction of vasomotor symptoms in peri- and postmenopausal women

Aim. To conduct a comparative analysis of serum orexin A levels in women of different age periods with and without sleep disorder and vasomotor symptoms. To evaluate the dynamics of orexin A levels under menopausal hormone therapy. Materials and methods. The study included 50 postmenopausal women and 30 women of reproductive age with a regular menstrual cycle. Using block randomization, patients are divided into 3 groups: group 1 (main group), n=25, -STRAW+ 10 (+1b and +1c), patients with sleep disorder and vasomotor symptoms; group 2 (comparison group), n=25, STRAW+ 10 (+1b and +1c), patients with vasomotor symptoms without sleep disorder; group 3 (control group), n=30, STRAW+ 10 (-4), women of reproductive age without sleep disorder. Group 1 patients were given menopausal hormone therapy. A comparative analysis was carried out using the questionnaire for assessing menopausal symptoms severity by the Greene Scale (the Greene Climacteric Scale) and Rating Scale for subjective sleep characteristics. After 12 weeks of treatment, a control examination was performed. Results. In group 1 women, the serum orexin A levels were significantly higher compared to the women without the symptoms. The link between the orexin A levels and menopause syndrome severity was established. A significant decrease in the menopausal symptoms severity after 12 weeks of menopausal hormone therapy was shown. It was accompanied by a 1,3-fold decrease in orexin A levels. Conclusions. The obtained data indicate the possible role of orexin A and the orexin neuropeptide system in the pathogenesis of sleep disorder and vasomotor symptoms in postmenopausal women.

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Faculty Opinions recommendation of Vasomotor symptoms and cardiovascular events in postmenopausal women.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.8950957.12585056 ◽

2011 ◽

Author(s):

Margaret Rees

Keyword(s):

Postmenopausal Women ◽

Cardiovascular Events ◽

Vasomotor Symptoms

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Estradiol patches were effective in relieving moderate to severe vasomotor symptoms in postmenopausal women

Evidence-based Obstetrics and Gynaecology ◽

10.1054/ebog.2000.0129 ◽

2000 ◽

Vol 2 (2) ◽

pp. 55

Author(s):

George Adonakis

Keyword(s):

Postmenopausal Women ◽

Vasomotor Symptoms

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CENTRAL OBESITY ASSOCIATED WITH CHARACTERISTICS OF VASOMOTOR SYMPTOMS IN MENOPAUS WOMEN

SEAJOM: The Southeast Asia Journal of Midwifery ◽

10.36749/seajom.v7i1.103 ◽

2021 ◽

Vol 7 (1) ◽

pp. 39-43

Author(s):

YUNIAR SETYAWATI ◽

Ashon Sa’adi ◽

Tiyas Kusumaningrum

Keyword(s):

Postmenopausal Women ◽

Central Obesity ◽

Sampling Technique ◽

Vasomotor Symptoms ◽

Cross Sectional ◽

Direct Measurements ◽

Contingency Coefficient ◽

The Central Nervous System ◽

Cross Sectional Design ◽

System Body

Vasomotor complaints are common on postmenopausal women. Most women feel these complaints within 2 years after entering menopause; some of them will even feel up to a decade. In addition to vasomotor complaints, the incidence of central obesity also increases in menopause. The poor adipocyte system in central obesity that affects the central nervous system, body temperature and excessive sympathetic nerve activity have been suspected to be a cause of vasomotor syndrome at menopause. The purpose of this study was to analyze the relationship between central obesity and the characteristic of vasomotor symptoms in postmenopausal women. Method: this observational analytic study used a cross sectional design. The number of samples were 86 women aged 45-55 years who had been in postmenopausal period. Sampling technique was consecutive sampling. The independent variable was central obesity while the dependent variable was vasomotor symptoms. The data was taken using modified MENQOL questionnaire and direct measurements waist circumference to determine central obesity in the respondents. Data was tested using contingency coefficient test with α 0.05. Results: There were 59.3% respondents who experienced central obesity. More than eighty percent respondents with central obesity also experienced vasomotor symptoms which were considered disturbing. There was a significant relation between central obesity and the characteristic of vasomotor symptoms in postmenopausal women (p=0.00; r=0.513). Conclusion: The presence of central obesity leads to disturbing vasomotor symptoms in postmenopausal women

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Prevalence of menopausal symptoms among women with a history of breast cancer and attitudes toward estrogen replacement therapy.

Journal of Clinical Oncology ◽

10.1200/jco.1995.13.11.2737 ◽

1995 ◽

Vol 13 (11) ◽

pp. 2737-2744 ◽

Cited By ~ 215

Author(s):

R J Couzi ◽

K J Helzlsouer ◽

J H Fetting

Keyword(s):

Breast Cancer ◽

Replacement Therapy ◽

Postmenopausal Women ◽

Cancer Patients ◽

Estrogen Replacement Therapy ◽

Uterine Cancer ◽

Emotional Problem ◽

Vasomotor Symptoms ◽

Breast Cancer Patients ◽

Estrogen Replacement

PURPOSE To determine the prevalence and severity of vasomotor, gynecologic, and other symptoms among breast cancer patients, their health concerns, beliefs about estrogen replacement therapy (ERT), and willingness to take estrogen under medical supervision. MATERIALS AND METHODS A questionnaire was mailed to 320 women aged 40 to 65 years and diagnosed with in situ or invasive locoregional breast cancer in the years 1988 to 1992. RESULTS Of 222 eligible respondents, 190 were postmenopausal. The prevalence of symptoms among the postmenopausal women was as follows: hot flashes, 65%; night sweats, 44%; vaginal dryness, 48%; dyspareunia, 26%; difficulty sleeping, 44%; and feeling depressed, 44%. The latter two symptoms increased in frequency with increasing severity of vasomotor symptoms (P for trend < or = .001). Forty-one percent of menopausal women perceived that they had experienced, since their breast cancer diagnosis, a physical or emotional problem related to menopause. Of these women, 50% felt they needed treatment. Overall, 31% of postmenopausal women would consider taking estrogen. Those who perceived that they had experienced a menopausal problem were more likely to consider estrogen than those who did not (42% v 22%, P = .003). The proportions willing to take estrogen increased with increasing severity of symptoms, particularly feelings of depression and sleep disturbance (P for trend = .008 and .007, respectively). Awareness that estrogen decreases the risks of heart disease and osteoporosis was not associated with an increased willingness to take it. However, beliefs that estrogen increases the risks of recurrent breast cancer and uterine cancer were associated with a decreased willingness to take it (P = .003 and .08, respectively). CONCLUSION Vasomotor symptoms have a significant impact on the quality of life of breast cancer patients. Clinical trials to determine the safest and the most effective ways to relieve these symptoms are needed.

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A 17β-Estradiol–Progesterone Oral Capsule for Vasomotor Symptoms in Postmenopausal Women

Obstetrics and Gynecology ◽

10.1097/aog.0000000000002645 ◽

2018 ◽

Vol 132 (1) ◽

pp. 161-170 ◽

Cited By ~ 27

Author(s):

Rogerio A. Lobo ◽

David F. Archer ◽

Risa Kagan ◽

Andrew M. Kaunitz ◽

Ginger D. Constantine ◽

...

Keyword(s):

Postmenopausal Women ◽

Vasomotor Symptoms ◽

17Β Estradiol ◽

Oral Capsule

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Efficacy of Citalopram as a Monotherapy or as an Adjunctive Treatment to Estrogen Therapy for Perimenopausal and Postmenopausal Women With Depression and Vasomotor Symptoms

The Journal of Clinical Psychiatry ◽

10.4088/jcp.v64n0419 ◽

2003 ◽

Vol 64 (4) ◽

pp. 473-479 ◽

Cited By ~ 72

Author(s):

Claudio N. Soares ◽

Jennifer R. Poitras ◽

Jennifer Prouty ◽

Allison B. Alexander ◽

Jan L. Shifren ◽

...

Keyword(s):

Postmenopausal Women ◽

Estrogen Therapy ◽

Adjunctive Treatment ◽

Vasomotor Symptoms

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Resistance training decreases plasma levels of adipokines in postmenopausal women

Scientific Reports ◽

10.1038/s41598-020-76901-w ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Liam J. Ward ◽

Sigrid Nilsson ◽

Mats Hammar ◽

Lotta Lindh-Åstrand ◽

Emilia Berin ◽

...

Keyword(s):

Resistance Training ◽

Postmenopausal Women ◽

Sex Hormones ◽

Plasma Levels ◽

Controlled Trial ◽

Venous Blood ◽

Sex Hormone Binding Globulin ◽

Vasomotor Symptoms ◽

Lipocalin 2 ◽

Randomised Controlled

AbstractPhysical inactivity and the onset of menopause increase the risk of cardiovascular disease amongst postmenopausal women. We aim to investigate the effect of resistance training (RT) on plasma levels of selected cytokines, adipokines, myokines, and sex hormones in postmenopausal women with vasomotor symptoms. This was a sub-study of a randomised controlled trial investigating the effects of RT on vasomotor symptoms in postmenopausal women. Women were randomised to join a 15-week RT program (n = 26) or remain sedentary as control (n = 29). Venous blood samples were taken at week-0 and week-15 for all participants. Enzyme-linked immunosorbent assays and multiple bead assays were used to measure cytokines, adipokines, myokines, and sex hormones in plasma. Plasma measurements of 16 of 33 analytes were within detectable limits. After adjusting for good compliance in the RT group (58% of RT participants), after 15 weeks, significantly lower plasma levels of adiponectin (p < 0.001), lipocalin-2 (p < 0.01) and resistin (p = 0.04) were found. Comparing control and RT women, using change-over-time values, significant increases in median testosterone and sex hormone binding globulin levels were seen in RT women. RT intervention lowers the levels of adipokines, particularly adiponectin, in postmenopausal women with vasomotor symptoms. These results were secondary outcomes of a clinical trial, and further investigations in a larger cohort are essential with the additional control of diet control and body composition analyses. Nevertheless, our study shows RT may be a beneficial intervention in reducing inflammation amongst postmenopausal women.

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