scholarly journals Uterine torsion in a Sprague Dawley rat (Rattus norvegicus)

2011 ◽  
Vol 82 (3) ◽  
Author(s):  
K. H. Erlwanger ◽  
M. A. Costello ◽  
L. C. R. Meyer
Keyword(s):  
Histopathological Examination ◽  
Rare Condition ◽  
Hepatic Necrosis ◽  
Uterine Horn ◽  
Sprague Dawley ◽  
Metabolic Complications ◽  
Sprague Dawley Rat ◽  
Uterine Torsion ◽  
Lymphocytic Infiltrates ◽  
The Right

Uterine torsion is a twisting of the uterus or uterine horn perpendicular to its long axis.We report a case of uterine torsion in an adult breeding Sprague Dawley rat. The rat died a month after her last recorded delivery. Post mortem examination of the rat revealed 270° torsion of the right uterine horn. The uterus contained a single foetus. The liver was pale and enlarged. The rest of the viscera appeared normal. Histopathological examination showed acute hepatic necrosis and pulmonary congestion with mild lymphocytic infiltrates peribronchially. The acute hepatic necrosis may have been associated with septicaemia due to compromised blood vessels following the uterine torsion. The presence of a single foetus could have resulted in foeto-maternal disproportion with resultant uterine torsion. Torsion of the uterus can be accompanied by haemostatic and metabolic complications, which could have caused the death of the rat. Although uterine torsion is a rare condition in rats, it should be considered as a potential complication of gestation in animal breeding units.

scholarly journals Potency of Murraya koenigii Leaves as Anti-Cancer Mammary in 7,12 dimethylbenz(α) anthracene (DMBA) induced-Sprague Dawley Rats

2020 ◽  
Vol 151 ◽  
pp. 01058
Author(s):  
Siti Aisyah ◽  
Ekowati Handharyani ◽  
Nurliani Bermawie ◽  
Agus Setiyono
Keyword(s):  
Mammary Tumor ◽  
Tumor Size ◽  
Histopathological Examination ◽  
Tumor Development ◽  
Collagen Fibers ◽  
Female Rats ◽  
Sprague Dawley ◽  
Murraya Koenigii ◽  
Sprague Dawley Rat ◽  
Sprague Dawley Rats

The purpose of the research was to study the potency of Murraya koenigii leaves extract to overcome the mammary tumor in Sprague Dawley rat. Thirty-five female rats were divided into seven groups: control (P1), tumor without therapy (P2), methotrexate group (P3), curative groups (P4 and P5) were given extract after the tumor was formed, and preventive groups (P6 and P7) were given extract before the tumor was formed with dose of 300 and 400 mg/kg, respectively. The induction of mammary tumor in rats were carried out using 7,12 dimethylbenz(α) anthracene (DMBA) subcutaneously. Bodyweight and tumor size were measured every week for 4 weeks. At the end of treatment, rats were euthanized and mammary glands were collected for histopathological examination. The result showed tumor size in P2 was significantly higher (p<0.05) than in other groups. On the other hand, tumor size in P4 and P6 were significantly smaller (p<0.05) compared to P5 and P7. Histopathological changes showed PMN cells, 1-3 layers of cuboid epithelial and solid collagen fibers proliferation in P2, while in P3 to P7 showed moderate collagen fibers proliferation. In conclusion, the administration of the extract at a dose of 300 mg/kg can decelerate tumor development in Sprague Dawley rat mammary gland.

scholarly journals Vasa Vasorum Formation is Associated With Rupture of Intracranial Aneurysms

Neurosurgery ◽  
2019 ◽  
Vol 66 (Supplement_1) ◽  
Author(s):  
Haruka Miyata ◽  
Hirokazu Koseki ◽  
Kampei Shimizu ◽  
Yu Abekura ◽  
Mieko Oka ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Intracranial Aneurysms ◽  
Histopathological Examination ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Vasa Vasorum ◽  
Systemic Hypertension ◽  
External Carotid ◽  
Anterior Communicating Artery ◽  
Sprague Dawley ◽  
The Right

Abstract INTRODUCTION Subarachnoid hemorrhage has a poor outcome despite a modern advancement in medical care. The development of a novel therapeutic strategy to prevent rupture of intracranial aneurysms (IAs) or a novel diagnostic marker to predict rupture-prone lesions is thus mandatory. Therefore, in the present study, we established a rat model in which IAs spontaneously rupture and examined this model to clarify histopathological features associated with rupture of lesions. METHODS In detail, female Sprague-Dawley rats were subjected to the bilateral ovariectomy, the ligation of the left common carotid, the right external carotid, and the right pterygopalatine arteries, the induced systemic hypertension, and the administration of a lysyl oxidase inhibitor. RESULTS Aneurysmal subarachnoid hemorrhage occurred one-thirds of manipulated animals and locations of ruptured IAs were exclusively at a posterior or an anterior communicating artery. Histopathological examination using ruptured IAs, rupture-prone ones induced at a posterior or an anterior communicating artery, ones induced at an anterior cerebral artery-olfactory artery bifurcation that never rupture revealed the formation of vasa vasorum as an event associated with rupture of IAs. CONCLUSION We thus proposed the contribution of a structural change in an adventitia, vasa vasorum formation, to rupture of IAs. Findings from this study provide important insights about the pathogenesis of IAs.

A Rare Case of a Pedicled Mobile Thrombus in Right Atrium

2016 ◽  
Vol 19 (6) ◽  
pp. 269 ◽  
Author(s):  
Xiaodong Li ◽  
Liping Chen ◽  
Xiumei Duan ◽  
Xiaocong Wang
Keyword(s):  
Right Atrium ◽  
Histopathological Examination ◽  
Rare Condition ◽  
Computed Tomographic Angiography ◽  
Right Atrial ◽  
Atrial Thrombus ◽  
Computed Tomographic ◽  
Right Atrial Thrombus ◽  
The Right ◽  
Tomographic Angiography

Pedicled mobile thrombus in the right atrium is an extremely rare condition. Here, we described a case of a 42-year-old male hospitalized with complaints of chest pain and hemoptysis. Computed tomographic angiography of the pulmonary artery showed signs of embolism, and thoracic echocardiography indicated a pedicled mobile cloudy echo in the right atrium, which was initially suspected to be a myxoma. However, it was confirmed to be a thrombus by histopathological examination. Postoperatively, the patient was treated with anticoagulant therapy comprising of low molecular heparin and warfarin, and the patient recovered well. Thoracic echocardiography performed 3 months after surgery ruled out any recurrence of right atrial thrombus.

scholarly journals Elastofibroma Dorsi, a Rare Condition, with Challenging Diagnosis. Case Report and Literature Review

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 370
Author(s):  
Octavian Neagoe ◽  
Cosmin Ioan Faur ◽  
Mihaela Ionică ◽  
Flavia Baderca ◽  
Roxana Folescu ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Histopathological Examination ◽  
Rare Condition ◽  
Surgical Excision ◽  
High Rate ◽  
Biological Entity ◽  
Fatty Tissue ◽  
Oncologic Surgery ◽  
Elastofibroma Dorsi ◽  
The Right

Elastofibroma dorsi (ED) is known as a particular clinical and biological entity. We report a case of a bilateral elastofibroma dorsi (ED) in a 65-year-old female who presented to the Department of General and Oncologic Surgery of Emergency Clinical Municipal Hospital Timisoara, Romania. The patient was symptomatic on the right side, presenting pain in the interscapulothoracic region associated with a variable tumoral mass, dependent on the position of the right arm. Imaging studies revealed a well-defined, bilateral tumoral mass with alternation of the muscular and fatty tissue. The initial diagnosis of lipoma was taken into consideration based on the CT scan and clinical findings. Surgical excision of the right subscapular tumor was performed without any postoperative complications. Microscopic examination of hematoxylin and eosin, Masson’s trichrome, and orcein stained slides revealed the diagnosis of ED. Considering the high rate of reported postoperative complications and the asymptomatic presentation of the contralateral subscapular mass, the patient underwent clinical and imagistic monitoring for the contralateral tumor. Due to its rare nature, ED is a difficult preoperative diagnosis that can, however, be suggested by its specific location and may require an accurate histopathological examination for a final diagnosis.

scholarly journals The role of adipose tissue in the healing of rat uterine wall after a full-thickness surgical incision

2021 ◽  
Vol 10 (4) ◽  
pp. 72-80
Author(s):  
N.B. Tikhonova ◽  
◽  
A.P. Milovanov ◽  
V.V. Aleksankina ◽  
T.V. Fokina ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Uterine Wall ◽  
Uterine Horn ◽  
Morphometric Study ◽  
Full Thickness ◽  
Sprague Dawley ◽  
Surgical Incision ◽  
Laboratory Rodents ◽  
The Right

Introduction. Data about the role of components of adipose tissue in the repair of damaged uterine walls are limited, although a number of authors claim that cell-based drugs from adipose tissue have a positive effect on the repair of damaged uterine walls in laboratory rodents. Meanwhile, stem cells derived from adipose tissue are considered to be the most promising type of cells in regenerative medicine. The aim of the studywas to evaluate the adipocyte components in the uterine wall of rats in healing after a full-thickness surgi-cal incision. Materials and methods. We conducted the study on 40 female Sprague Dawley rats. The animals were sub-jected to a full-thickness longitudinal incision in the wall of the right uterine horn, with the left one serving as an intact control. We carried out morphological examinations of the uterine walls daily in 5 animals from day 1 to 7 and on day 15. The sections from paraffin blocks were stained with hematoxylin and eosin and Mallory’s trichrome staining. Immunohistochemistry detected FABP4+ adipocytes and CD68+ macrophages. The morphometric study was carried out using the Leica system (Leica, Germany). The results underwent processing in the Statistica 12 software (StatSoft). Results. We noticed the period of the most active interaction of adipose tissue with the damaged horn to last from day 3 to 15 and coincide with the macrophage activation in the healing zone. The intact left uterine horn was not involved in the interaction processes with the mesenteric adipose tissue. Starting from day 3 FABP4+ cells in the uterine wall of the operated horn formed groups, creating rounded nest-like structures. Clusters of FABP4+ cells were localized in the healing zone, near the suture material, and in the perime-trium near the mesentery attachment sites. The changes over time of the indicators of the area of cell nests depended on the localization and duration of healing. There were no FABP4+ cells in the left intact horn. Conclusion. We characterized the morphological interaction of adipose tissue with the damaged uterine wall during the first two weeks after a full-thickness surgical incision of the rat uterine horn. The results of the study indicate that adipocytes take an active part in the healing after a surgical incision of the rat uterine wall at the earliest stages. Keywords: rat uterus, hysterotomy, healing, adipocytes, macrophages

Vasa vasorum formation is associated with rupture of intracranial aneurysms

2020 ◽  
Vol 133 (3) ◽  
pp. 789-799 ◽  
Author(s):  
Haruka Miyata ◽  
Hirohiko Imai ◽  
Hirokazu Koseki ◽  
Kampei Shimizu ◽  
Yu Abekura ◽  
...  
Keyword(s):  
Intracranial Aneurysms ◽  
Lysyl Oxidase ◽  
Histopathological Examination ◽  
Oxidase Inhibitor ◽  
Vasa Vasorum ◽  
Systemic Hypertension ◽  
External Carotid ◽  
Anterior Communicating Artery ◽  
Sprague Dawley ◽  
The Right

OBJECTIVESubarachnoid hemorrhage (SAH) has a poor outcome despite modern advancements in medical care. The development of a novel therapeutic strategy to prevent rupture of intracranial aneurysms (IAs) or a novel diagnostic marker to predict rupture-prone lesions is thus mandatory. Therefore, in the present study, the authors established a rat model in which IAs spontaneously rupture and examined this model to clarify histopathological features associated with rupture of lesions.METHODSFemale Sprague Dawley rats were subjected to bilateral ovariectomy; the ligation of the left common carotid, the right external carotid, and the right pterygopalatine arteries; induced systemic hypertension; and the administration of a lysyl oxidase inhibitor.RESULTSAneurysmal SAH occurred in one-third of manipulated animals and the locations of ruptured IAs were exclusively at a posterior or anterior communicating artery (PCoA/ACoA). Histopathological examination using ruptured IAs, rupture-prone IAs induced at a PCoA or ACoA, and IAs induced at an anterior cerebral artery–olfactory artery bifurcation that never ruptured revealed the formation of vasa vasorum as an event associated with rupture of IAs.CONCLUSIONSThe authors propose the contribution of a structural change in an adventitia, i.e., vasa vasorum formation, to the rupture of IAs. Findings from this study provide important insights about the pathogenesis of IAs.

scholarly journals Torsión uterina e hidrometra unilateral en una coneja (Oryctolagus cuniculus) de compañía

2019 ◽  
Vol 5 ◽  
Author(s):  
Elizabeth Morales-Salinas ◽  
Fabiola Preza-Romero ◽  
Mónica Denise Quintal-Parra ◽  
Juan Cortés García
Keyword(s):  
Oryctolagus Cuniculus ◽  
Reproductive Tract ◽  
Uterine Horn ◽  
Abdominal Distention ◽  
Histopathological Diagnosis ◽  
Female Rabbit ◽  
Uterine Torsion ◽  
Normochromic Anemia ◽  
The Right ◽  
Uterine Adenocarcinoma

Descripción del caso. Coneja de compañía (Oryctolagus cuniculus) de cinco años de edad, de raza palomino, nulípara, que dejó de comer y beber gradualmente, y estaba apática.Hallazgos clínicos. Tenía el abdomen notablemente distendido, con peloteo y dolor a la palpación, estaba deshidratada y deprimida. El hemograma y la bioquímica sanguínea indicaron anemia severa altamente regenerativa normocrómica, hiperazotemia prerrenal, hipoproteinemia e hipoalbuminemia. En el ultrasonido y estudio radiográfico, se observó que el útero estaba muy dilatado con abundante líquido, lo que sugería hidrometra, o bien, hemometra.Tratamiento y evolución. Durante su hospitalización fue medicada con enrofloxacina, tramadol y meloxicam. Al realizar la ovariohisterectomía, se observó que el cuerno uterino derecho estaba torcido por completo con abundante líquido sanguinolento. Se diagnosticó torsión uterina e hidrometra unilateral derecha. La coneja murió un día después de la cirugía.Pruebas de laboratorio. En el examen histológico, el endometrio estaba muy hemorrágico y necrosado con pérdida de la mucosa y de las glándulas endometriales, con marcada congestión y edema en todas las capas uterinas. El diagnóstico histopatológico del útero fue emitido como hemorragia y necrosis endometrial grave, difusa y edema transmural grave difuso.Relevancia clínica. Las enfermedades del tracto reproductor en conejas de edad avanzada y no esterilizadas como el adenocarcinoma uterino y la hiperplasia endometrial son comunes. Estas patologías pueden acompañarse de hidrometra y hemometra afectando a ambos cuernos uterinos. El hallazgo relevante en este caso es que la torsión y la hidrometra de un solo cuerno uterino se presentaron juntas, quizá estaban relacionadas, lo que se ha documentado poco. Las patologías uterinas en conejas se pueden prevenir con ovariohisterectomía a edad temprana. Cuando una coneja presenta distención abdominal, además de considerar patologías uterinas como en este caso, se debe descartar enfermedad cardiaca, renal o alguna neoplasia abdominal. Abstract Case description. A five years old, palomino breed, nulliparous, pet female rabbit (Oryctolagus cuniculus), which gradually stop eating and drinking and was apathetic.Clinical findings and interpretation. Physical examination revealed prominent abdominal distention, pain and puddle sing on abdominal palpation and depression. Hematological and chemistry values revealed severe strongly regenerative normochromic anemia, prerenal azotemia, hypoproteinemia, and hypoalbuminemia. The ultrasound and radiographic study revealed that the uterus was extremely dilated with abundant fluid suggesting hydrometra or hemometra.Treatment and evolution. The rabbit during her hospitalization was treated with enrofloxacin, tramadol and meloxicam. At ovariohysterectomy, it was observed that the right uterine horn was completely twisted and approximately 800 mL of bloody fluid were collected from inside it. Unilateral uterine torsion and hydrometra were diagnosed. The rabbit died one day after surgery.Laboratory tests. Histologically, the endometrium was severely hemorrhagic and necrotic with loss of the uterine epithelium and endometrial glands, in addition there was marked congestion and edema in all the uterine layers. The histopathological diagnosis of the uterus was emitted as severe diffuse hemorrhage and necrosis endometrial and severe diffuse transmural edema.Clinical relevance. Reproductive tract diseases in unsterilized mature age rabbits such as uterine adenocarcinoma and endometrial hyperplasia are common. These abnormalities can be accompanied by hydrometra and hemometra affecting both uterine horns. As a relevant finding in this case is that the torsion and hydrometra of a single uterine horn were presented together and there may be a relationship between them which has been slight referenced. Uterine pathologies in rabbits can be prevented by performing ovariohysterectomy in young animals. When a female rabbit presents abdominal distention, in addition to considering uterine abnormalities as in this case, heart or kidney disease or some abdominal neoplasm should be included in the differential diagnosis.Keywords: uterus, pseudopregnancy, surgery, lagomorph, pathology.

scholarly journals Uterine torsion in a full-term pregnant cat

2017 ◽  
Vol 3 (2) ◽  
pp. 205511691772622
Author(s):  
Kohei Kuroda ◽  
Tomohiro Osaki ◽  
Kazuki Harada ◽  
Masamichi Yamashita ◽  
Yusuke Murahata ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Surgical Intervention ◽  
Uterine Horn ◽  
Fetal Survival ◽  
Uterine Torsion ◽  
Life Saving ◽  
History Of ◽  
Initial Support ◽  
The Right ◽  
Early Surgical Intervention

Case summary A 5-year-old intact female Maine Coon cat presented with a 2 day history of lethargy, anorexia and anaemia. The cat had bred 60 days previously and jumped from a height 3 days earlier, which was followed by a worsening of its condition. Ultrasonography revealed that two fetuses had died and one remained alive. Urgent surgical intervention was deemed necessary, and the cat underwent a blood transfusion and laparotomy. The right uterine horn was dark red in appearance and had rotated 360° in the clockwise direction at its base. Subsequently, an ovariohysterectomy and caesarean section were performed, and the fetus in the left uterine horn initially survived. Although the cat appeared to recover from anaemia and physical injury, the kitten died on postoperative day 1. Relevance and novel information In cases involving only one twisted uterine horn, the fetuses located in the contralateral horn could potentially survive; however, many such fetuses do not survive, and only a few reports have described fetal survival in a pregnant cat with uterine torsion. In the present case, early surgical intervention and blood transfusion allowed us to save the cat. Our findings demonstrate the life-saving abilities of initial support treatment and early surgical intervention for both the pregnant cat and fetuses in cases of acute abdomen caused by uterine torsion.

scholarly journals Giant Inflammatory Fibroid Polyp of the Hepatic Flexure of Colon Presenting with an Acute Abdomen

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Ashish Lal Shrestha ◽  
Pradita Shrestha
Keyword(s):  
Histopathological Examination ◽  
Rare Condition ◽  
Exploratory Laparotomy ◽  
Right Hemicolectomy ◽  
Acute Onset ◽  
Hepatic Flexure ◽  
Inflammatory Fibroid Polyp ◽  
Intermittent Fever ◽  
Fibroid Polyp ◽  
The Right

Background.Inflammatory Fibroid Polyp (IFP) of the colon is an exceedingly rare condition. Since 1952 till now only 32 cases have been reported worldwide of which only 5 were giant (>4 cm) polyps mostly found in the caecum (15 cases) with only 3 in the descending colon.Case Presentation.A 36-year-old female with no previous illness presented to the emergency unit with an acute onset pain over the right hypochondrium for 3 days associated with intermittent fever and anorexia. As she had evidence of localized peritonitis she underwent a diagnostic laparoscopy and subsequently an exploratory laparotomy. A mass measuring 8 × 7 × 5 cm arising from the hepatic flexure of colon was noted. Right hemicolectomy with ileotransverse anastomosis was performed. The mass was subsequently reported to be IFP.Conclusion.IFP is a very rare condition with clinical presentation depending upon its size and location. Definitive diagnosis is possible with histopathological examination of tissue aided by immunohistochemical studies. Surgical resection has been the most common method of treatment especially for large and giant colonic IFPs owing to challenges in terms of diagnosis and technical difficulties associated with endoscopic methods.

Cryptococcal infection of the larynx: case report

2013 ◽  
Vol 127 (S2) ◽  
pp. S54-S56 ◽  
Author(s):  
N Mittal ◽  
P Collignon ◽  
T Pham ◽  
M Robbie
Keyword(s):  
Case Report ◽  
Vocal Fold ◽  
Histopathological Examination ◽  
Rare Condition ◽  
Cryptococcus Gattii ◽  
Causative Organism ◽  
Adequate Treatment ◽  
Imaging Results ◽  
The Right ◽  
Laryngeal Involvement

AbstractObjective:Laryngeal cryptococcosis is a rare condition. In this report, we describe the findings for and treatment of a 58-year-old man withCryptococcus gattiiinfection of the right vocal fold.Method:Case report and review of the relevant English language literature.Results:The patient presented with persistent hoarseness of voice. Laryngoscopy demonstrated an irregular, red lesion on the right vocal fold. Histopathological examination identified cryptococcus. The patient was treated with oral fluconazole 400 mg/day for eight weeks.Conclusion:Laryngeal involvement byCryptococcus gattiican result from prolonged inhaled corticosteroid therapy and proximity to eucalyptus trees. The clinical presentation, laryngoscopic findings and imaging results of laryngeal involvement may mimic a neoplasm. Histopathological examination can demonstrate the causative organism. Management consists of advice from an infectious disease specialist together with adequate treatment by antifungal agents.

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