scholarly journals Nephroprotective effect of Bauhinia variegata (linn.) whole stem extract against cisplatin-induced nephropathy in rats

2011 ◽  
Vol 43 (2) ◽  
pp. 200 ◽  
Author(s):  
Sabuj Sahoo ◽  
PrasanaK Panda ◽  
SaumyaR Pani ◽  
Satyaranjan Mishra
Keyword(s):  
Stem Extract ◽  
Bauhinia Variegata ◽  
Nephroprotective Effect

Identification and Isolation of lupeol and β-sitosterol from Iraqi Bauhinia variegata and determination the cytotoxic activity of the hexane extract of its leaves, stems and flowers

2021 ◽  
pp. 5703-5708
Author(s):  
Mais Mohammed ◽  
Monther F Mahdi ◽  
Bassma Talib ◽  
Ibrahim S Abaas
Keyword(s):  
Cytotoxic Activity ◽  
Pharmacological Study ◽  
Hexane Extract ◽  
Cytotoxic Action ◽  
Tropical Regions ◽  
Medicinal Tree ◽  
Aerial Parts ◽  
Stem Extract ◽  
Bauhinia Variegata ◽  
Mcf 7

Objective: Bauhinia variegata is evergreen small medicinal tree grows all over the world especially in the tropical regions. The aims of the study were detection, isolation quantification and identification of β-sitosterol and lupeol of Iraqi B. variegata stem using various chromatographic and spectroscopic methods, beside the cytotoxic investigation of hexane extract of different aerial parts. Methods: detection by GC mass spectroscopy, isolated by preparative TLC. The identification and the structural elucidation of isolated β-sitosterol and lupeol were performed by 1H nuclear magnetic resonance and FTIR. While the cytotoxic activity was performed against MCF-7 cells line. Results: Results highlighted that β-sitosterol and lupeol present in Iraqi B. variegata stem that confirmed by different chromatographic and spectroscopic analysis. Also the leaves extract has the superior action on MCF-7 cells followed by stem extract and end up by flower extract. Conclusions: The plant has a good content of both β-sitosterol and lupeol and the good cytotoxic action of aerial parts hexane extract confirm the successful plantation of B. variegata. These isolated compounds are a suitable candidate for further pharmacological study.

Extraction, isolation and characterization of Bauhinia variegata flower

2020 ◽  
pp. 9-12
Author(s):  
Akanksha Gupta ◽  
Abhishek K Tripathi ◽  
Pushpraj S Gupta
Keyword(s):  
Biological Activities ◽  
Molecular Formula ◽  
Native Plant ◽  
Compound A ◽  
Active Constituents ◽  
Chromatographic Techniques ◽  
Isolation And Characterization ◽  
Soxhlet Apparatus ◽  
Bauhinia Variegata

Background: Bauhinia variegata Linn. is a native plant of Asia and China. B. variegata is found in tropical regions of the world. It belongs to family Leguminosae. It is used for diarrhea, hemorrhoids, constipation, piles, edema, leprosy, wounds, tumors, etc.  Objective: The objective of the present study was to perform extraction of B. variegata flower and isolation of active constituents from the extract. Materials and Methods: The ethanolic extraction of B. variegata flower was performed using the Soxhlet apparatus. The isolation of active constituents from the extract was performed using chromatographic techniques. In column chromatographic studies, n-hexane- [dichloromethane (DCM)] (2:8) was used as an eluting system and further purified through thin layer chromatography (TLC). Compound A and B were isolated through chromatographic techniques, then the molecular formula and characterization of these compounds were carried out with mass and infrared (IR) spectral analysis. Results and Discussion: The percentage yield of B. variegata ethanolic extract (BVE) was found to be 20.8% w/w. The different fractions were F1 having 12.5 grams with n-hexane, F2 (17.1 grams) with CH2Cl2, F3 (21.2 grams) with EtOAc, and F4 (13.4 grams) with EtOH. Compound A and B were isolated from the solvent fractions of n-hexane-DCM (2:8) and EtOAc-DCM (1:9), respectively. The compound A was characterized as 3-hydroxy-6-methoxy-2-phenyl-4H-chromen-4-one. The compound B was characterized as 3-hydroxy-6-methyl-2-phenyl-4H-chromen-4-one. Conclusion: Thus, B. variegata flowers possess active components that need to identify their biological activities.

Anti-inflammatory, analgesic activity, and toxicity of Pituranthos scoparius stem extract: An ethnopharmacological study in rat and mouse models

2020 ◽  
Vol 258 ◽  
pp. 112936 ◽  
Author(s):  
Ahlem Karbab ◽  
Kamel Mokhnache ◽  
Soraya Ouhida ◽  
Noureddine Charef ◽  
Farida Djabi ◽  
...  
Keyword(s):  
Mouse Models ◽  
Analgesic Activity ◽  
Stem Extract ◽  
Anti Inflammatory

Nephroprotective effect of Vanillic acid in STZ-induced diabetic rats

2021 ◽  
Author(s):  
Savita Kumari ◽  
Anjoo Kamboj ◽  
Manish Wanjari ◽  
Anil Kumar Sharma
Keyword(s):  
Vanillic Acid ◽  
Diabetic Rats ◽  
Nephroprotective Effect

scholarly journals Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy

2021 ◽  
Vol 22 (3) ◽  
pp. 1239
Author(s):  
Matilde Zaballos ◽  
Mercedes Power ◽  
María Iluminada Canal-Alonso ◽  
María Ángeles González-Nicolás ◽  
Wenceslao Vasquez-Jimenez ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Fluid Management ◽  
Urine Volume ◽  
Chemotherapeutic Agents ◽  
Control Group ◽  
Specific Data ◽  
Preoperative Risk Factors ◽  
Hyperthermic Chemotherapy ◽  
Chemotherapy Perfusion ◽  
Nephroprotective Effect

Cisplatin is one of the most widely used chemotherapeutic agents in oncology, although its nephrotoxicity limits application and dosage. We present the results of a clinical study on prophylaxis of cisplatin-induced nephrotoxicity in patients with peritoneal carcinomatosis undergoing cytoreduction and hyperthermic intraperitoneal intraoperative chemotherapy (HIPEC-cisplatin). Prophylaxis was with imipenem/cilastatin. Cilastatin is a selective inhibitor of renal dehydropeptidase I in the proximal renal tubule cells that can reduce the nephrotoxicity of cisplatin. Unfortunately, cilastatin is not currently marketed alone, and can only be administered in combination with imipenem. The study has a retrospective part that serves as a control (n = 99 patients receiving standard surgical prophylaxis) and a prospective part with imipenem/cilastatin prophylaxis corresponding to the study group (n = 85 patients). In both groups, we collected specific data on preoperative risk factors of renal damage, fluid management, hemodynamic control, and urine volume during surgery (including the hyperthermic chemotherapy perfusion), as well as data on hemodynamic and renal function during the first seven days after surgery. The main finding of the study is that cilastatin may exert a nephroprotective effect in patients with peritoneal carcinomatosis undergoing cytoreduction and hyperthermic intraperitoneal cisplatin perfusion. Creatinine values remained lower than in the control group (ANOVA test, p = 0.037). This translates into easier management of these patients in the postoperative period, with significantly shorter intensive care unit (ICU) and hospital stay.

scholarly journals Histochemistry and immunolocalisation of glucokinin in antidiabetic plants used in traditional Mexican medicine

2017 ◽  
Author(s):  
Guillermo Laguna-Hernández ◽  
Carlos A. Rio-Zamorano ◽  
Itzel G. Meneses-Ochoa ◽  
Alicia E. Brechú-Franco
Keyword(s):  
Medicinal Plants ◽  
Public Health Problem ◽  
Direct Application ◽  
Glucosidase Inhibitors ◽  
Naphthol Blue Black ◽  
Bauhinia Variegata ◽  
Alpha Glucosidase ◽  
Antidiabetic Plants

Mexico is a megadiverse country that has 3,600 to 4,000 species of medicinal plants, of which approximately 800 are used to treat conditions related to diabetes mellitus (DM). DM is a chronic degenerative disease of energy metabolism that exists as two types: type 1 (DM1) and type 2 (DM2). DM is considered a public health problem that affects 7% of the Mexican population older than 20 years. DM is clinically controlled with hypoglycaemic drugs, alpha-glucosidase inhibitors, insulin secretion stimulants or the direct application of insulin. The hypoglycaemic effectiveness of specific molecules has been determined only for some medicinal plants in Mexico used to treat DM2. The presence of molecules called glucokinins, wich are similar to animal insulin molecules, has been reported in some plant species; glucokinins act as both growth factors and regulators of glucose metabolism in plants. Therefore, we hypothesized that the hypoglycaemic effectiveness of some of the popularly used species for the control of DM could be due to the presence of glucokinin, as reported for Bauhinia variegata. The goal of this work was to use histochemistry to detect, the accumulation of protein that is immunocytochemically compatible with glucokinin in slide sections of hypoglycaemic species used as remedies for DM2. The top fourteen most used medicinal plants in Mexico were selected for study via microscopic sections. Proteins were histochemically detected using naphthol blue black and Johansen’s quadruple stain, and the immunocytochemical correspondence of the proteins with glucokinin was investigated using an insulin antibody. All species studied reacted positively to proteins and glucokinin in the same structures. The presence of glucokinin in these structures and the corresponding hypoglycaemic effects are discussed in the contex of the actions of other compounds.

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