scholarly journals Alcoholic leaf extract of Plectranthus amboinicus regulates carbohydrate metabolism in alloxan-induced diabetic rats

2011 ◽  
Vol 43 (3) ◽  
pp. 286 ◽  
Author(s):  
A. H. M. Thippeswamy ◽  
A. H. M. Viswanatha Swamy ◽  
Rucha Kulkarni ◽  
BC Koti ◽  
Aparna Gore
Keyword(s):  
Carbohydrate Metabolism ◽  
Leaf Extract ◽  
Diabetic Rats ◽  
Plectranthus Amboinicus

Watermelon ( Citrullus lanatus ) leaf extract attenuates biochemical and histological parameters in high‐fat diet/streptozotocin‐induced diabetic rats

2022 ◽  
Author(s):  
Muhammad Mustapha Jibril ◽  
Azizah Haji‐Hamid ◽  
Faridah Abas ◽  
Jeeven Karrupan ◽  
Abdulkarim Sabo Mohammed ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Leaf Extract ◽  
Citrullus Lanatus ◽  
Diabetic Rats ◽  
High Fat

scholarly journals Alcoholic Stem Extract ofCoscinium fenestratumRegulates Carbohydrate Metabolism and Improves Antioxidant Status in Streptozotocin–Nicotinamide Induced Diabetic Rats

2005 ◽  
Vol 2 (3) ◽  
pp. 375-381 ◽  
Author(s):  
I. R. Punitha ◽  
K. Rajendran ◽  
Arun Shirwaikar ◽  
Annie Shirwaikar
Keyword(s):  
Carbohydrate Metabolism ◽  
Antioxidant Status ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Glutathione Synthetase ◽  
Alcoholic Extract ◽  
Enzymatic Antioxidants ◽  
Stem Extract ◽  
Gluconeogenic Enzyme ◽  
Glucose 6 Phosphate Dehydrogenase

Alcoholic extract of the stems ofCoscinium fenestratum, a medicinal plant indigenous to India and Sri Lanka used in ayurveda and siddha medicine for treating diabetes, was studied for its carbohydrate metabolism effect and antioxidant status in streptozotocin–nicotinamide induced type 2 diabetic rats. Oral administration ofC. fenestratumstem extract in graded doses caused a significant increase in enzymatic antioxidants such as catalase, superoxide dismutase, glutathione synthetase, peroxidase, and glutathione peroxidase and in the nonenzymatic antioxidants ascorbic acid, ceruloplasmin and tocopherol. Effects of alcoholic extract on glycolytic enzymes such as glucose-6-phosphate dehydrogenase, lactate dehydrogenase and hexokinase showed a significant increase in their levels, whereas a significant decrease was observed in the levels of gluconeogenic enzyme, glucose-6-phosphatase and alanine aminotransferase in treated diabetic rats. Serum creatinine and urea levels also declined significantly. This investigation demonstrates significant antidiabetic activity ofC. fenestratum.

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