scholarly journals The effect of sikkam (Bischofia javanica) leaf extract on blood sugar levels and islet of langerhans in alloxan-induced diabetic rats

2021 ◽  
Vol 713 (1) ◽  
pp. 012046
Author(s):  
C G P Rumahorbo ◽  
S Hutahaean ◽  
S Ilyas
Keyword(s):  
Blood Sugar ◽  
Leaf Extract ◽  
Diabetic Rats ◽  
Islet Of Langerhans ◽  
Bischofia Javanica ◽  
Sugar Levels

scholarly journals Effectiveness of combination of Moringa Leaf Extract (Moringa oleifera Lamk.) and Papaya Seed Extract (Carica papaya L.) in reducing blood sugar levels of diabetic rats

2021 ◽  
pp. 215-219
Author(s):  
Novi Ayuwardani ◽  
Yetti Hariningsih
Keyword(s):  
Blood Sugar ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Diabetic Rats ◽  
Seed Extract ◽  
Lower Blood ◽  
Post Test ◽  
Sugar Levels ◽  
Moringa Leaf Extract ◽  
Papaya Seed

Introduction: Moringa leaf extract and papaya seed extract contain flavonoids that can lower blood sugar levels. Objectives: The purpose of this study was to determine the antidiabetic effectiveness of moringa leaf extract and papaya seed extract and the effective dose of moringa leaf extract and papaya seed extract in reducing blood sugar levels. Methods: This study used 24 diabetic rats. Diabetes was induced by giving rats glucose 10% for four days. Measurement of blood sugar levels was carried out on the 0th, 5th, 8th, and 15th days. The pre-test (T1) and post-test (T2 and T3) blood sugar levels were measured, as well as the percentage of reduction at T2 and T3. Results: The result was that the treatment group with an extract combination of 700:500 showed decreased blood sugar levels on day 15 (57.24%), indicating antidiabetic effectiveness of the extract combination.

scholarly journals UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN ECENG GONDOK (Eichhornia crassipes (Mart.)Solms) DAN DAUN SINTRONG (Crassocephalum crepidioides (Benth.) S. Moore) PADA MENCIT

2021 ◽  
Vol 4 (1) ◽  
pp. 44-53
Author(s):  
Andri Priyoherianto ◽  
◽  
Panji Ratih Suci ◽  
Putri Rizki Cahya Fatimah ◽  
Atik Nur Wijayanti
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Water Hyacinth ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Glucose Levels ◽  
Normal Limits ◽  
Blood Glucose Levels ◽  
Sugar Levels

Diabetes mellitus is a chronic metabolic disorder that occurs due to destruction of pancreatic ? cells characterized by blood glucose levels that exceed normal limits. The purpose of this study was to determine the therapeutic effect of the combination of water hyacinth leaf extract and Sintrong leaf in reducing blood glucose levels in alloxan-induced experimental animals. Water hyacinth leaf powder and Sintrong leaves were extracted using the maceration method with 70% ethanol as a solvent. A total of 25 mice were divided into 5 groups, namely negative control CMC-Na 0.5%, positive control glibenclamide 0.00065 mg / g BW, water hyacinth leaf extract 17.5 mg / kg BW, Sintrong leaf extract 10.5 mg/ kg BW and a combination of water hyacinth leaf extract 17.5 mg / kg BW and sintrong leaf 10.5 mg / kg BW. The results showed that a single extract of water hyacinth and Sintrong leaves was able to reduce blood sugar levels for 7 days. The combination dose was effective in reducing blood sugar levels with a combination dose of 17.5 mg/ kg water hyacinth leaf extract in combination for 7 days.

scholarly journals The Difference in Effect of Arabica Coffee Gayo Beans and Leaf (Coffea Arabica Gayo) Extract on Decreasing Blood Sugar Levels in Healthy Mice

2019 ◽  
Vol 7 (20) ◽  
pp. 3363-3365
Author(s):  
Sake Juli Martina ◽  
Pradeepa A. P. Govindan ◽  
Arlinda Sari Wahyuni
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Leaf Extract ◽  
Alternative Therapy ◽  
Postprandial Blood Glucose ◽  
Control Group ◽  
Arabica Coffee ◽  
Before And After ◽  
The Difference ◽  
Sugar Levels

BACKGROUND: High incidence rate of diabetes mellitus (DM) and increased incidence of complications from DM as well as the use of less effective antidiabetic drugs and high financing to treat demands alternative therapy. AIM: This study was conducted to determine the difference in the effect of Arabica coffee gayo bean and leaf extract on blood sugar levels in healthy mice before and after the intervention of extract and fasting and postprandial blood glucose level after consumption of glucose. METHODS: This research is an experimental research study. The study used experimental animals which were divided into 8 groups which are the control group (Aquadest), group given Acarbose, the group given the Arabica coffee gayo bean extract with dosage of 50 mg, 100 mg and 200 mg in healthy mice, the group given the Arabica coffee gayo leaf extract with dosage of 30 mg, 60 mg and 120 mg in healthy mice. RESULTS: The results of the study obtained are before and after the intervention of extract showed the difference of p= 0.523 and after consumption of glucose the fasting and postprandial result showed the difference of p = 0.005. CONCLUSION: The use of Arabica coffee gayo bean and leaf extract showed a high decrease in blood glucose levels (BGL) compared to the control group.

scholarly journals Effect of Bay Leaf Extract (Syzygium polyanthum) on Blood Sugar Regulation via GLUT4 Protein Regulation in White Rat Muscle Tissue Induced Aloxan

2020 ◽  
Vol 1 (1) ◽  
pp. 24-31
Author(s):  
Rachmat Hidayat ◽  
Lusia Hayati
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Muscle Tissue ◽  
Leaf Extract ◽  
Negative Control ◽  
Diabetes Group ◽  
White Rats ◽  
Target Blood Glucose ◽  
Sugar Regulation ◽  
Sugar Levels

Diabetes mellitus is a chronic condition that disturbs the body's bloodsugar regulation. Bay leaves contain entirely various secondary metabolites,where this plant is rich in flavonoids, alkaloids, terpenes and glycosides. Thisstudy aims to assess the effect of bay leaf extract (Syzygium polyanthum) onblood sugar levels and the expression of GLUT4 protein in muscle tissue. A totalof 30 white rats (Rattus norvegicus) Wistar strain obtained from the EurekaResearch Laboratory (Palembang, Indonesia) weighing between 200 - 250 grams.Bay leaf simplicia was obtained from the Tawangmangu Herbal Research Center,Karanganyar, Indonesia. After 1 week of adaptation, the mice were randomlydivided into the following six groups, each containing 5 animals: Normal controlgroup, diabetes group (negative control), diabetes + metformin group (Met; 45mg / kg), Diabetes + BLE (75 mg/kg), diabetes + BLE group (150 mg / kg) anddiabetes + BLE group (300 mg/kg). Alloxan-induced white rats showed a verysignificant increase in blood sugar levels, where the use of the drug metforminwas able to reduce blood sugar levels significantly even though they had notreached the target blood glucose target of less than 200 mg / dL. The treatmentwith bay leaf extract was able to reduce blood sugar levels significantly. Theadministration of metformin drugs or bay leaf extract showed the ability toincrease the level of GLUT4 protein. In conclusion, bay leaf extract affectsreducing blood sugar levels in diabetes mellitus white rats by increasing glucoseintake to cells and tissues.

scholarly journals Pengaruh Pemberian Koro Benguk (Mucuna pruriens L) terhadap Kadar Gula Darah Tikus Diabetes Melitus yang Diinduksi Streptozotocin

2020 ◽  
Vol 2 (2) ◽  
pp. 136-140
Author(s):  
Endang Widhiyastuti ◽  
Mastuti Widi Lestari
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Observation Time ◽  
The Body ◽  
Mucuna Pruriens ◽  
Control Group ◽  
Sprague Dawley ◽  
Sugar Levels

Diabetes which is well-known in the community as diabetes in Indonesia is a chronic disease, which occurs when the pancreas does not produce enough insulin or when the body cannot utilize the insulin produced by its own products. The Provision of antioxidants in DM mice can reduce blood sugar levels. One of the herbs that can be used for control and management of blood sugar in diabetes is swollen koro. Koro Benguk (Mucuna pruriens L) is a plant that can be used as an alternative treatment because it contains antioxidants that can maintain health without causing toxic effects. The purpose of this study was to determine whether there is an effect of giving koro benguk coffee (Mucuna pruriens L) on blood sugar levels of Streptozotocin-induced Diabetes Mellitus Rats. This study is an experimental study of Sprague Dawley mice. A total of 35 male wistar rats were divided into 5 groups each: normal control (K1); diabetes control (K2); diabetic rats were given a large coffee extract 0.63 mg / g BW rat (P1); diabetic rats were given a large infusion of coffee koro 1.26 mg / g BW rats (P2). Diabetic rats were given an infusion of coffee koro benguk20,52 mg / g BW rats. Fasting blood glucose (GDP) levels were analyzed weekly for 3 weeks using the GOD-PAP method. The results of the study showed a decrease in blood sugar for 4 times the observation time in almost all treatment groups except the positive control group. The conclusions in this study were the provision of related coffee (Mucuna pruriens L) can reduce fasting blood glucose levels in Sprague Dawley rats with diabetes models significantly compared to controls.

scholarly journals UJI EFEK EKSTRAK GEDI MERAH (Abelmoschus manihot L. Medik) TERHADAP KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus novergicus) YANG DIINDUKSI ALOKSAN

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Friska Adeline ◽  
Jane Wuisan ◽  
Henoch Awaloei
Keyword(s):  
Blood Sugar ◽  
Blood Sugar Level ◽  
Leaf Extract ◽  
White Male ◽  
Male Rats ◽  
Male Rat ◽  
The People ◽  
Wistar Strain ◽  
Medicinal Substances ◽  
Sugar Levels

Abstract: Epidemiological study in Manado indicated that the prevalence of Diabetes Melitus (DM) was 6.1%. It is necessary to do scientific assessment of the various species of plants which are thought containing medicinal substances (phytopharmaca). Based on the information from the people living in the subdistrict Pineleng Minahasa red gedi leaves (Abelmoschus manihot L.Medik ) can be used as herbal treatment for lowering blood sugar level. This study aimed to evaluate the effect of red gedi leaves extract in lowering blood sugar level on white male rat induced by aloksan. This study used 15 white male rats of Wistar strain with diabetic induced by 200 mg/kg BW aloksan intraperitoneal. The rats were randomly divided into 5 groups; each group were given aquadest 2,5 ml/ 200 g BW, insulin Novomix 0,9 U/Kg BW, red gedi leaf extract 1.25 mg/200 g BW, 2.5 mg/200 g BW, and 3.75 mg/200 g BW, once daily for 24 hours. Blood sugar levels were measured at 6th, 12th, 18th, and 24 th hours after treatment by using glucometer. The result showed that red gedi leaf extract can lower blood level in diabetic white male rat induced by aloksan.Keywords: red gedi leaf extract, blood glucose, aloksan, diabeticAbstrak: Pada penelitian epidemiologis di kota Manado didapatkan prevalensi penderita DM 6,1 %. Untuk itu perlu dilakukan pengkajian ilmiah terhadap berbagai spesies tumbuhan yang diduga mengandung zat berkhasiat obat (fitofarmaka). Berdasarkan informasi masyarakat di daerah kecamatan Pineleng kabupaten Minahasa daun Gedi Merah (Abelmoschus manihot L.Medik) dapat dimanfaatkan sebagai penanganan herbal untuk menurunkan kadar gula darah. Penelitian ini bertujuan menguji efektivitas ekstrak daun Gedi Merah (Abelmoschus manihot L. Medik) dalam menurunkan kadar gula darah tikus putih jantan galur Wistar (Rattus norvegicus) yang diinduksi aloksan. Tikus galur Wistar sejumlah 15 dinduksi dengan aloksan intraperitoneal 200 mg/kg BB dan dibagi secara acak dalam 5 kelompok penelitian yaitu kelompok perlakuan dengan aquadest 2,5 ml/200 g BB, insulin Novomix 0,9 U / Kg BB, ekstrak daun gedi merah 1,25 mg/ 200 g BB, 2,5 mg/ 200 g BB dan 3,75 mg/ 200 g BB. Perlakuan diberikan satu kali sehari selama 6 hari. Pengukuran kadar glukosa darah dilakukan pada hari ke 2, 4 dan 6 setelah perlakuan menggunakan glukometer. Hasil penelitian menunjukkan bahwa ekstrak daun gedi merah dapat menurunkan kadar glukosa darah tikus putih jantan diabetes yang diinduksi dengan aloksan.Kata kunci: ekstrak daun gedi merah, glukosa darah, aloksan, diabetes

scholarly journals STUDIES ON GLYCOGEN NEPHROSIS IN ALLOXAN-TREATED DIABETIC RATS

1947 ◽  
Vol 85 (4) ◽  
pp. 373-379 ◽  
Author(s):  
G. W. Curtis ◽  
S. L. Robbins ◽  
I. Glickman
Keyword(s):  
Blood Sugar ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Maximum Height ◽  
A Value ◽  
Reversible Lesion ◽  
Glycogen Deposition ◽  
Sugar Levels ◽  
Terminal Blood ◽  
Convoluted Tubules

Two hundred and seven albino rats were injected subcutaneously with alloxan in doses varying from 140 to 200 mg. per cent per kilo of body weight. Fifty-nine animals which developed hyperglycemia (blood sugar levels above 150 mg. per cent) were observed for periods from 5 days to 32 weeks. Postmortem examination of the kidneys of these diabetic animals revealed glycogen deposition in the loops of Henle and convoluted tubules in 26 rats or 44 per cent. Glycogen could not be demonstrated in the glomeruli. Within the time limits of this experiment (32 weeks) no intercapillary glomerulosclerosis was observed. The following facts were revealed regarding glycogen nephrosis in alloxan diabetes: (a) Its appearance in the kidneys of the diabetic rats depended solely upon the terminal blood sugar levels of these animals. A value of 350 mg. per cent was the critical level, above which glycogen nephrosis was almost invariably demonstrable. With terminal levels below 300 mg. per cent no glycogen nephrosis was found. (b) No relationship existed between the postmortem finding of glycogen nephrosis and the initial blood sugar level, or the maximum height of the hyperglycemia attained by individual rats. (c) The results suggest that glycogen nephrosis is a reversible lesion.

scholarly journals Anti-hyperglyceamic Effects of Psidium guajava LINN Crude Leaf Extracts and Fractions in Alloxan- induced Diabetic Mice.

2021 ◽  
Author(s):  
Eze Uchenna Nwabunwanne ◽  
Eze Anthonius Anayaochukwu ◽  
Ugwu Chukwuebuka Victor ◽  
Onuoha Maxwell ◽  
Ubenyi Stanley Mary
Keyword(s):  
Ethyl Acetate ◽  
Blood Sugar ◽  
Leaf Extract ◽  
Lethal Dose ◽  
Psidium Guajava ◽  
Diabetic Mice ◽  
Leaf Extracts ◽  
Crude Leaf Extract ◽  
The Mean ◽  
Sugar Levels

Abstract In Nigeria, rural inhabitants often resort to herbal remedies and dietary control for the treatment and management of various forms of diabetes mellitus. This study was conducted to provide the rationale for the use of Psidium guajava leaves as a potent traditional antidiabetic remedy. The crude leaf extracts of n-hexane, methanol, and ethyl acetate of Psidium guajava were separately prepared by cold maceration. Then, the ethyl acetate crude extract of Psidium guajava leaves was fractionated by column chromatography to yield ethyl acetate bulked fractions: EF-I (1-75), EF-II (76-150), and EF- III (151-250). The n-hexane, ethyl acetate, and methanol crude leaf extracts and ethyl acetate bulked fractions (EF-I, EF-II, and EF-III) were evaluated for antidiabetic activity in alloxan-induced diabetic mice. The blood sugar levels of treated and untreated alloxan-induced diabetic mice were assayed as indices of antidiabetic effect. The phytochemical constituents of both crude extracts and ethyl acetate fractions of Psidium guajava leaves and the mean lethal dose (LD50) of ethyl acetate crude leaf extract of Psidium guajava were determined. The mean lethal dose (LD50) of ethyl acetate crude leaf extract was calculated to be 1500mg/kg b.w. The results indicated that oral administration of ethyl acetate, n-hexane, methanol crude extract, and ethyl acetate bulked fractions of Psidium guajava leaves at a dose of 100mg/kg b.w on treated groups exhibited much significant[p<0.001, p<0.01and p<0.05]anti- hyperglyceamic effect by ameliorating high blood sugar levels of alloxan-induced diabetic treated mice, while EF-II and EF-III showed non-significant[p>0.05] anti-hyperglyceamic activity for the reduction in blood sugar levels compared with the negative and positive control groups. The anti- diabetic potency of the crude leaf extracts and ethyl acetate fractions were in the order; EC>HC>MC>EF-I>EF-II>EF-III. The results of phytochemical screening of the crude extracts and ethyl acetate bulked fractions showed the presence of tannins, flavonoids, saponins, alkaloids, terpenoids, glycosides, and steroids while reducing sugar was absent. The results from this study give credence to the use of Psidium guajava as an antidiabetic agent in the management of diabetes mellitus.

scholarly journals EFEKTIVITAS ANTIDIABETES EKSTRAK DAUN RAMBUSA (Passiflora foetida L.) PADA MENCIT (Mus musculus) DENGAN INDUKSI GLUKOSA

2015 ◽  
Vol 1 (2) ◽  
pp. 99-104
Author(s):  
Khildah Khaerati ◽  
Ihwan Ihwan ◽  
Musdalifah S Maya
Keyword(s):  
Blood Sugar ◽  
Leaf Extract ◽  
Drug Research ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Antidiabetic Drug ◽  
Passiflora Foetida ◽  
Sugar Levels

Passiflora foetida leaves used by the society for generations as a natural antidiabetic drug research aims to test the effectiveness of the leaf extract of Passiflora foetida with variations of a dose of 250 mg / kg, 500 mg / kg, and 750 mg / kg in lowering blood sugar levels in mice. Passiflora foetida leaves were extracted by sokhletasi method with 70% ethanol, the extract was tested on 15 mice, the test animals were randomized into 5 groups consist of negative control group given 0.5% Na-CMC, positive control group was given glibenclamide 0, 65 mg / kg, and the treatment group were given the leaf extract of Passiflorafoetida with variations of each dose of 250 mg / kg, 500 mg / kg, 750 mg / kg. To increase blood sugar levels in mice induced glucose 50%. Measurement of blood sugar levels in mice were performed using an easy touch glucometer and blood is taken via the lateral tail vein. The results showed that the percentage of blood sugar levels drop to a negative control is 13.1%, for a dose of 250 mg / kg body weight of 29.52%, for a dose of 500 mg / kg was 38.79%, to dosis750 mg / kg was 49, 21%, and 48.1% for the positive control. The results showed that the leaf extract of Passiflorafoetida at a dose of 750 mg / kg is most effective as an antidiabetic

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