Changing trend in susceptibility to vancomycin of methicillin susceptible and resistant Staphylococcus aureus clinical isolates from a tertiary care centre

Background: Staphylococcus aureus continues to be major healthcare problem worldwide as therapeutic options for its management are limited. Decolonisation regimes using mupiroicin are aimed at reducing the burden of infection due to this microorganism. However resistance to mupirocin poses a threat to the current standard eradication protocols.Aims: To find out the type and extent of mupirocin resistance in clinical isolates of S. aureus. Material and methods: This cross-sectional study was carried out at a tertiary care centre of North India for a period of 6 months. S. aureus recovered by standard microbiological procedures form various clinical samples such as blood, urine, pus and other body fluids was subjected to antimicrobial susceptibility testing along with detection of mupirocin resistance using 5 and 200µg discs. Minimum inhibitory concentration (MIC) of mupirocin was determined using E -test strips. Fisher’s exact test was done to determine the statistical significance. A P-value of <0.05 was considered as statistically significant.Results: A total of 247 S. aureus isolates were recovered of which 81 (32.8%) were resistant to methicillin (MRSA) whereas 166 (67.2%) were sensitive to this antibiotic (MSSA). Low level resistance to mupirocin was seen in 7 (8.6%) MRSA and 3 (1.8%) MSSA isolates. Prior use of this topical antibiotic and previous hospitalisation were found to be the risk factors associated with mupirocin resistance. Conclusion: Low level mupirocin resistance was seen in S. aureus isolates which if left unchecked could in future pave way for high level resistance and subsequent treatment failures.

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Emerging Antimicrobial Resistance Among Methicillin Resistant Staphylococcus Aureus (MRSA) in a Tertiary Care Centre in North India

JMS SKIMS ◽

10.33883/jms.v23i1.747 ◽

2020 ◽

Vol 23 (1) ◽

pp. 48-49

Author(s):

Javaid Ahmad Bhat ◽

Shariq Rashid Masoodi

Keyword(s):

Staphylococcus Aureus ◽

Antimicrobial Resistance ◽

Tertiary Care ◽

Resistance Mechanisms ◽

North India ◽

Global Public Health ◽

Care Centre ◽

Tertiary Care Centre ◽

Effective Prevention ◽

Mupirocin Resistance

Apropos to the article by Dr Bali, titled “Mupirocin resistance in clinical isolates of methicillin-sensitive and resistant Staphylococcus aureus in a tertiary care centre of North India” (1), the authors have raised important issue of emerging antimicrobial resistance (AMR). Antimicrobial resistance is an increasingly serious threat to global public health that requires action across all government sectors and society. As per WHO, AMR lurks the effective prevention and management of an ever-increasing spectrum of infections caused by bacteria, parasites, fungi and viruses. Novel resistance mechanisms are emerging and spreading globally, threatening the man’s ability to treat common infectious diseases.

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