scholarly journals Transforming growth factor-β1 and TGF-β2 act synergistically in the fibrotic pathway in oral submucous fibrosis: An immunohistochemical observation

2015 ◽  
Vol 36 (2) ◽  
pp. 111 ◽  
Author(s):  
VenkateshViswanath Kamath ◽  
Shruti Krishnamurthy ◽  
KrishnanandP Satelur ◽  
Komali Rajkumar
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Oral Submucous Fibrosis ◽  
Transforming Growth Factor Β1 ◽  
Submucous Fibrosis

scholarly journals Small Molecule “Silmitasertib” Repurposed as Inhibitor of Transforming Growth Factor Beta 1 for the Development of Therapeutics for Oral Submucous Fibrosis

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Nezar Boreak
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Oral Submucous Fibrosis ◽  
Normal Tissues ◽  
Premalignant Condition ◽  
Submucous Fibrosis ◽  
Transformation Potential ◽  
Growth Factor Beta ◽  
Tgf Β1

Oral submucous fibrosis (OSMF) is considered a premalignant condition characterized by aggressive fibrosis of the submucosal tissues of the oral cavity reflecting its malignant transformation potential. Activation of transforming growth factor beta (TGF-β) signaling has been reported to lead increased collagen production and fibrosis. Recently, significant upregulation of TGF-β1 has been reported in OSMF as compared to normal tissues. Therefore, inhibition of the TGF-β1 may pave for the development of therapeutics of OSMF. Based on the structure-assisted drug designing, we found “silmitasertib” as potent inhibitor of TGF-β1. We suggest that this molecule can be validated and implemented for the treatment of OSMF.

scholarly journals Expression of transforming growth factor beta in oral submucous fibrosis

2020 ◽  
Vol 10 (2) ◽  
pp. 166-170 ◽  
Author(s):  
Arpita Rai ◽  
Tanveer Ahmad ◽  
Shama Parveen ◽  
Saba Parveen ◽  
Md Imam Faizan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis ◽  
Growth Factor Beta
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