scholarly journals Burden of different beta-lactamase classes among clinical isolates of AmpC-producing Pseudomonas aeruginosa in burn patients: A prospective study

2012 ◽  
Vol 16 (3) ◽  
pp. 136-140 ◽  
Author(s):  
V. Kumar ◽  
M. R. Sen ◽  
C. Nigam ◽  
R. Gahlot ◽  
S. Kumari



2019 ◽  
Vol 68 (5) ◽  
pp. 778-784 ◽  
Author(s):  
Ana Filipa Pedrosa ◽  
Carmen Lisboa ◽  
Isabel Faria-Ramos ◽  
Raquel Silva ◽  
Elisabete Ricardo ◽  
...  


2010 ◽  
Vol 4 (04) ◽  
pp. 239-242 ◽  
Author(s):  
Supriya Upadhyay ◽  
Malay Ranjan Sen ◽  
Amitabha Bhattacharjee

Introduction: Infections caused by Pseudomonas aeruginosa are difficult to treat as the majority of isolates exhibit varying degrees of beta-lactamase mediated resistance to most of the beta-lactam antibiotics. It is also not unusual to find a single isolate that expresses multiple β-lactamase enzymes, further complicating the treatment options. Thus the present study was designed to investigate the coexistence of different beta-lactamase enzymes in clinical isolates of P. aeruginosa. Methodology: A total of 202 clinical isolates of P. aeruginosa were tested for the presence of AmpC beta-lactamase, extended spectrum beta-lactamase (ESBL) and metallo beta-lactamase (MBL) enzyme. Detection of AmpC beta-lactamase was performed by disk antagonism test and a modified three-dimensional method, whereas detection of ESBL was done by the combined disk diffusion method per Clinical and Laboratory Standards Institute (CLSI) guidelines and MBL were detected by the Imipenem EDTA disk potentiation test. Results: A total of 120 (59.4%) isolates were confirmed to be positive for AmpC beta-lactamase. Among them, 14 strains (7%) were inducible AmpC producers. Co-production of AmpC along with extended spectrum beta-lactamase and metallo beta-lactamase was reported in 3.3% and 46.6% isolates respectively. Conclusion: The study emphasizes the high prevalence of multidrug resistant P. aeruginosa producing beta-lactamase enzymes of diverse mechanisms. Thus proper antibiotic policy and measures to restrict the indiscriminative use of cephalosporins and carbapenems should be taken to minimize the emergence of this multiple beta-lactamase producing pathogens.



Author(s):  
Ana Irina Mereuţă ◽  
Aida Corina Bădescu ◽  
Olivia Simona Dorneanu ◽  
Luminiţa Smaranda Iancu ◽  
Cristina Gabriela Tuchiluş


1992 ◽  
Vol 101 (10) ◽  
pp. 866-869 ◽  
Author(s):  
Dan M. Fliss ◽  
Naftali Meidan ◽  
Ron Dagan ◽  
Alberto Leiberman

Medical management of chronic suppurative otitis media without cholesteatoma in children was shown recently to be efficacious. We undertook a prospective study in order to determine 1) the organisms associated with the disease and their sensitivity to various antibiotics and 2) their association with clinical variables. Pseudomonas was isolated from 84% of the patients, enteric gram-negative bacilli from 32%, Staphylococcus aureus from 20%, streptococci from 14%, and Hemophilus influenzae from 15%. Pseudomonas aeruginosa was the sole isolate in 48 of the 128 patients (38%). The sensitivity of P aeruginosa (78 isolates) was 100% (of isolates) to mezlocillin and ciprofloxacin, 99% to tobramycin and ceftazidime, 97% to piperacillin, 94% to gentamicin, and 78% to ceftriaxone. The isolated organisms and their sensitivity to antibiotics were not associated with age, sex, duration of otorrhea, or the presence of granulation tissue or polyps. We believe that our data may contribute to the appropriate choice of antibiotics when nonsurgical management of chronic suppurative otitis media without cholesteatoma is considered.



2012 ◽  
Vol 5 (3) ◽  
pp. 507-510 ◽  
Author(s):  
Enayatollah Kalantar ◽  
Vahideh Torabi ◽  
Himen Salimizand ◽  
Fariborz Soheili ◽  
Rashid Ramezanzadeh


Burns ◽  
2017 ◽  
Vol 43 (8) ◽  
pp. 1766-1774 ◽  
Author(s):  
Colin Lee ◽  
Sandra A.N. Walker ◽  
Scott E. Walker ◽  
Winnie Seto ◽  
Andrew Simor ◽  
...  


2001 ◽  
Vol 22 ◽  
pp. S66 ◽  
Author(s):  
W. L. Wahl ◽  
M. Brandt ◽  
K. S. Ahrns ◽  
P. J. Zajkowski ◽  
M. C. Proctor ◽  
...  


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