scholarly journals Squamous cell carcinoma cervix with metastasis to pyloroduodenal region

2011 ◽  
Vol 7 (2) ◽  
pp. 183 ◽  
Author(s):  
JomonC Raphael ◽  
Simon Pavamani ◽  
PN Viswanathan ◽  
ThomasSamuel Ram ◽  
Lisa Choudharie
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cervix

A PROSPECTIVE RANDOMIZED STUDY TO COMPARE THE CONCURRENT CHEMO-RADIATION VERSUS HYPO-FRACTIONATED CHEMO-RADIATION IN LOCALLY ADVANCED CERVICAL CANCER.

2021 ◽  
pp. 40-42
Author(s):  
Arpan Jana ◽  
Pabitra Das ◽  
Poulami Gupta ◽  
Phalguni Gupta
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
External Beam Radiotherapy ◽  
Locally Advanced ◽  
Intracavitary Brachytherapy ◽  
External Beam ◽  
Carcinoma Cervix ◽  
Advanced Carcinoma

Background: Concurrent chemo-radiation is the standard treatment worldwide for locally advanced squamous Cell carcinoma cervix. However, conventional chemo-radiotherapy is also associated with unacceptable local and systemic failure rates for locally advanced disease. Biologically squamous cell carcinoma of head- neck cancer and cervical cancer behaves quite similarly in response to radiotherapy. So, it can be expected that, altered fractionation can increase the local control in case of squamous cell carcinoma cervix than conventional radiotherapy. There is no randomised control trial for carcinoma cervix till date, which compares conventional chemo-radiation with hypo-fractionated chemo-radiation. Aims And Objectives: The present study was planned to compare local disease control and acute toxicity of conventional chemo-radiation with hypo-fractionated chemo-radiation in locally advanced carcinoma cervix. Materials And Methods: In Conventional Chemo-radiation Arm A patients (n=30) received external beam radiotherapy 50 Gy in 25 fractions in 5 weeks accompanied by weekly intravenous Cisplatin 40mg/m2 followed by intracavitary brachytherapy 7 Gy per fraction once in a week for 3 weeks. The second group of hypo-fractionated Arm B received external beam radiotherapy 45 Gy in 20 fractions in 4 weeks accompanied by weekly intravenous Cisplatin 40mg/m2 followed by intracavitary brachytherapy 9 Gy per fraction once in a week for 2 weeks. Results: Grade II diarrhea were seen more in Arm B 17 (56.66%) compare to Arm A 12(40%) and grade III diarrhea was seen 4 (3.33%) in Arm B and 2(6.66%) in Arm A. At 2 months and 6 months after completion of treatment Complete response were 25 (83.4%) in Arm A compare to 22 (73.3%) in Arm B and 20 (74.1%) in Arm A and 18 (72%) in Arm B respectively. Conclusion: Hypo-fractioned radiotherapy may be used as an alternate protocol for treatment of locally advanced carcinoma cervix with acceptable toxicities.

A CASE REPORT AND LITERATURE REVIEW: METACHRONOUS TUMOUR IN SINGLE PATIENT (CARCINOMA CERVIX AND CARCINOMA LUNG)

2021 ◽  
pp. 33-34
Author(s):  
Thamizholi S ◽  
Ranu Chourasia ◽  
Pearly Daimari ◽  
Balakyntiew Kharshandi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Systemic Chemotherapy ◽  
Time Interval ◽  
Lung Mass ◽  
Single Patient ◽  
Carcinoma Cervix ◽  
Primary Tumors ◽  
Ct Guided

INTRODUCTION: - Multiple primary tumors can be synchronous when detected simultaneously (or) metachronous when detected after a variable time interval. Association of two cancer in same patient is unusual but has been widely reported in the literature. CASE PRESENTAION: - A 55-year-old women was diagnosed in December 2018 as squamous cell carcinoma cervix FIGO STAGE IIIB & she received denitive chemoradiation 46GY/23# for 5 weeks with 5 cycles weekly injection carboplatin under AUC 2 followed by Brachytherapy and completed treatment in February 2019. She was on regular follow up till December 2020. Later she presented with upper back pain. She was evaluated for the same. CT Thorax suggestive of right upper lobe lung mass and PET- CT S/O Right Lung mass lesion with extension into spinal rd th canal & lytic destruction of D2/D3 Vertebrae and Right 3 , 4 rib. CT guided Biopsy s/o squamous cell carcinoma with IHC- p16 & p40-Positive, nd TTF-Negative and diagnosed as 2 primary carcinoma lung Stage IV. She received 6 cycles systemic chemotherapy completed in May 2021. She improved clinically & radiologically with systemic chemotherapy paclitaxel & carboplatin. CONCLUSION: - Metachronous tumor in single patient is unusual & management depends on stage of presentation.

scholarly journals Chronic uterine inversion with malignancy mimicking carcinoma cervix

2019 ◽  
Vol 12 (2) ◽  
pp. bcr-2018-225541
Author(s):  
Bhavana Girish ◽  
Amenda Ann Davis
Keyword(s):  
Squamous Cell Carcinoma ◽  
Postmenopausal Woman ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rare Event ◽  
Postmenopausal Bleeding ◽  
Carcinoma Cervix ◽  
Uterine Inversion ◽  
Irregular Growth ◽  
Uterine Fundus

Chronic non-puerperal uterine inversion is a rare event, with only a handful of cases reported in literature. We report a case of a 64-year-old postmenopausal woman who presented with complaints of mass per vaginam and postmenopausal bleeding. On examination, she appeared to have third-degree cervical descent with an irregular growth seen over what appeared to be the cervix, biopsy of which showed keratinising squamous cell carcinoma. Subsequently, an inverted uterus was diagnosed at laparotomy with an irregular growth seen over the inverted portion of the uterine fundus, histopathology of which revealed squamous cell carcinoma of endometrium.

scholarly journals Carcinoma uterine cervix metastasis to the skin: A rare case report

2016 ◽  
Author(s):  
Gajender Singh ◽  
Sant Parkash Kataria ◽  
Rajeev Sen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Metastasis ◽  
Excision Biopsy ◽  
Carcinoma Cervix ◽  
Morphological Pattern ◽  
Rare Case Report ◽  
Cutaneous Nodule ◽  
Bilateral Lung

Introduction: Most common site of metastasis from carcinoma cervix is lung, liver, bone and brain. Cutaneous metastasis is rare occurrence in carcinoma cervix. Incidence reported ranges from 0.1 to 2%. Common morphological pattern of skin metastases are nodules, plaques and inflammatory telangiectatic lesions. Materials and Methods: A 68 years old postmenopausal female diagnosed as squamous cell carcinoma of cervix stage III B. She was given chemotherapy and radiotherapy and on regular follow up without no evidence of disease locally. After two years she presented with a sub cutaneous nodule of approximately 5x4 cm size just below the left scapula of one month duration. There was no similar swelling in any other region. It was rapidly increased in size and painful. The FNAC of the nodule showed metastatic from squamous cell carcinoma. PET scan showed metastases in bilateral lung and pelvic lymph node with no evidence of local disease. Excision biopsy of the nodule confirmed the diagnosis. Conclusion: Cutaneous metastases from carcinoma cervix are rare. Differential diagnoses include benign dermatitis, subcutaneous phycomycosis, and plaque like mycosis fungoides.

Immunohistochemical expression of P16 and Ki-67 in uterine cervical neoplasms

2021 ◽  
Vol 6 (3) ◽  
pp. 194-200
Author(s):  
Kafil Akhtar ◽  
Shafaque Zabin ◽  
Zehra Mohsin ◽  
Shahid A Siddiqui
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Invasive Carcinoma ◽  
Large Cell ◽  
Carcinoma Cervix ◽  
Ki 67 ◽  
Early Detection Of Disease ◽  
Keratinizing Squamous Cell Carcinoma

To study the expression of Ki-67 and p16 in neoplastic lesions of uterine cervix and to evaluate the prognostic significance of tumour differentiation, histological type, stage and grade, depth of tumour invasion and lymphovascular invasion in women with neoplasia of uterine cervix. This study was performed on 50 biopsies and surgically resected specimens of uterine cervix, which were fixed in 10% formalin, processed, paraffin embedded and cut into 3-5 microns thickness, stained with hematoxylin and eosin stains and immunohistochemical staining by p16 and Ki-67 antibodies was performed and studied. Majority of cases of invasive carcinoma cervix were large cell non-keratinizing squamous cell carcinoma, 58 cases (48.2%). Majority of cases of invasive carcinoma cervix were seen in stage 2B, 40 (40.8%) cases followed by stage 3B, 24 (24.4%) cases. Out of 18 cases of large cell non-keratinizing squamous cell carcinoma, 12 (66.7%) showed 3+ positivity for Ki-67. 7 (53.8%) cases of stage 2A showed 3+ positivity, 3 (23.1%) cases each showed 2+ positivity for p16. 7 (36.8%) cases of moderately differentiated SCC showed 3+ positivity, 4 (21.1%) showed 2+ positivity and 5 (26.3%) showed 1+ positivity of Ki-67. Out of 10 stable patients, 4 (40.0%) showed negative p16 immunoexpression and all the 3 cases (100%) with recurrence showed 2+ positivity and 2 (100%) patients with metastasis showed 3+ positivity. Out of 10 stable patients, 6 (60%) showed negative Ki-67 immunoexpression and all the 3 (100%) cases with recurrence showed 3+ positivity and one each (50.0%) patient with metastasis showed 2+ positivity and 3+ positivity. p16 and Ki-67 immunomarkers are useful as a diagnostic and prognostic tool in cases with recurrence and metastasis, helping in early detection of disease progression.

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