Postcholecystectomy benign biliary stricture: Surgery is the gold standard

AbstractPost cholecystectomy bile duct strictures present a challenge to the treating physicians. Advancement in skills and technology offers alternative treatment modalities to the standard surgical repair. Contemporary series of surgical repair by experienced surgeons report excellent long-term results with <5% restricture rates. Endoscopic therapy is conceptually flawed, is not applicable to all patients, requires prolonged duration of treatment with multiple interventions. Surgical repair by an experienced surgeon is the “Gold Standard” of care in management of postcholecystectomy bile duct strictures.

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Long-term results of surgical repair of bile duct injuries following laparoscopic cholecystectomy

Surgery ◽

10.1067/msy.2000.108422 ◽

2000 ◽

Vol 128 (4) ◽

pp. 668-677 ◽

Cited By ~ 93

Author(s):

Scott R. Johnson ◽

Alison Koehler ◽

Linda K. Pennington ◽

Douglas W. Hanto

Keyword(s):

Laparoscopic Cholecystectomy ◽

Bile Duct ◽

Surgical Repair ◽

Long Term Results ◽

Bile Duct Injuries

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Long-Term Results of Surgical Repair of Bile Duct Injuries Following Laparoscopic Cholecystectomy

Surgery Gastroenterology and Oncology ◽

10.21614/sgo-25-4-194 ◽

2020 ◽

Vol 25 (4) ◽

pp. 194

Author(s):

Ghofrane Talbi ◽

Wael Ferjaoui ◽

Mohamed Hajri ◽

Houssem eddine Smati ◽

Sahir Omrani ◽

...

Keyword(s):

Laparoscopic Cholecystectomy ◽

Bile Duct ◽

Surgical Repair ◽

Long Term Results ◽

Bile Duct Injuries

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Surgical repair for bile duct injuries after cholecistectomy in a tertiary referral center: long term results

HPB ◽

10.1016/j.hpb.2019.10.1239 ◽

2019 ◽

Vol 21 ◽

pp. S961

Author(s):

E. Panettieri ◽

A.M. De Rose ◽

F. Ardito ◽

A. Coppola ◽

G. Nuzzo ◽

...

Keyword(s):

Bile Duct ◽

Surgical Repair ◽

Long Term Results ◽

Tertiary Referral ◽

Tertiary Referral Center ◽

Referral Center ◽

Bile Duct Injuries

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Surgical repair for bile duct injuries after cholecistectomy in a tertiary referral center: long term results

HPB ◽

10.1016/j.hpb.2019.10.136 ◽

2019 ◽

Vol 21 ◽

pp. S560

Author(s):

E. Panettieri ◽

A.M. De Rose ◽

F. Ardito ◽

A. Coppola ◽

G. Nuzzo ◽

...

Keyword(s):

Bile Duct ◽

Surgical Repair ◽

Long Term Results ◽

Tertiary Referral ◽

Tertiary Referral Center ◽

Referral Center ◽

Bile Duct Injuries

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Herbal Medicine for Glioblastoma: Current and Future Prospects

Medicinal Chemistry ◽

10.2174/1573406416666200130100833 ◽

2020 ◽

Vol 16 (8) ◽

pp. 1022-1043

Author(s):

Imran Khan ◽

Sadaf Mahfooz ◽

Mustafa A. Hatiboglu

Keyword(s):

Cell Proliferation ◽

Survival Rates ◽

Standard Of Care ◽

Natural Compounds ◽

Treatment Modalities ◽

Normal Brain ◽

The Central Nervous System ◽

Cycle Regulation ◽

Immense Potential

Background: Glioblastoma is one of the most aggressive and devastating tumours of the central nervous system with short survival time. Glioblastoma usually shows fast cell proliferation and invasion of normal brain tissue causing poor prognosis. The present standard of care in patients with glioblastoma includes surgery followed by radiotherapy and temozolomide (TMZ) based chemotherapy. Unfortunately, these approaches are not sufficient to lead a favorable prognosis and survival rates. As the current approaches do not provide a long-term benefit in those patients, new alternative treatments including natural compounds, have drawn attention. Due to their natural origin, they are associated with minimum cellular toxicity towards normal cells and it has become one of the most attractive approaches to treat tumours by natural compounds or phytochemicals. Objective: In the present review, the role of natural compounds or phytochemicals in the treatment of glioblastoma describing their efficacy on various aspects of glioblastoma pathophysiology such as cell proliferation, apoptosis, cell cycle regulation, cellular signaling pathways, chemoresistance and their role in combinatorial therapeutic approaches was described. Methods: Peer-reviewed literature was extracted using Pubmed, EMBASE Ovid and Google Scholar to be reviewed in the present article. Conclusion: Preclinical data available in the literature suggest that phytochemicals hold immense potential to be translated into treatment modalities. However, further clinical studies with conclusive results are required to implement phytochemicals in treatment modalities.

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Analysis of response of vitiligo to treatment with NBUVB

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20185105 ◽

2019 ◽

Vol 5 (1) ◽

pp. 37

Author(s):

J. Madhava Praveen ◽

Jatin Sidhwa

Keyword(s):

Adverse Effects ◽

Skin Disorder ◽

Environmental Risks ◽

Treatment Modalities ◽

Duration Of Treatment ◽

Autoimmune Attack ◽

Self Worth ◽

Good Treatment Response ◽

Dynamic Interplay

Background: Vitiligo is an acquired skin disorder characterised by white (depigmented) patches in the skin, due to the loss of functioning melanocytes. The disease can have devastating consequences on an individual’s relationships with others and internal feelings of self-worth. Vitiligo is caused by a dynamic interplay between genetic and environmental risks that initiates an autoimmune attack on melanocytes in the skin. Long term phototherapy has shown good response in the management of vitiligo. In this study we explore the efficacy of phototherapy in management of our vitiligo patients.Methods: 30 subjects were included in the study. Subjects were started on NBUVB at 300mj/cm2. Weekly 3 doses were given. Doses were increased after every 3rd sitting by 10%. In case of adverse effects treatment is withheld till resolution of symptoms following which NBUVB is given at 50% of the last dose and patient managed based on the response.Results: A majority of the subjects showed significant and persistent improvement within the first 3 months of initiation of treatment. The proportion of the patients showing improvement increased with duration of treatment.Conclusions: Our study has revealed the standard and significant role the phototherapy plays in the treatment of vitiligo as a monotherapy or as an adjuvant with other treatment modalities. With good treatment response and minimal side effect incidence, phototherapy is an important treatment modality in the management of vitiligo.

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Long-term results of secondary biliary repair for cholecystectomy-related bile duct injury: results of a tertiary referral center

Acta Chirurgica Belgica ◽

10.1080/00015458.2019.1570741 ◽

2019 ◽

Vol 120 (2) ◽

pp. 92-101

Author(s):

Julie Navez ◽

Jean-François Gigot ◽

Pierre H. Deprez ◽

Pierre Goffette ◽

Laurence Annet ◽

...

Keyword(s):

Bile Duct ◽

Bile Duct Injury ◽

Long Term Results ◽

Tertiary Referral ◽

Tertiary Referral Center ◽

Referral Center

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The long term results of endoscopic sphincterotomy (ES) for common bile duct lithiasis

Gastrointestinal Endoscopy ◽

10.1016/s0016-5107(05)80402-x ◽

1995 ◽

Vol 41 (4) ◽

pp. 387

Author(s):

N. Abdel Malak ◽

F. Prat ◽

G. Pelletier ◽

C. Buffet ◽

J. Fritsch ◽

...

Keyword(s):

Bile Duct ◽

Common Bile Duct ◽

Endoscopic Sphincterotomy ◽

Long Term Results

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Long-Term Results of Surgical Treatment of Popliteal Artery Aneurysms

International Surgery ◽

10.9738/intsurg-d-14-00301.1 ◽

2016 ◽

Vol 103 (5-6) ◽

pp. 315-322

Author(s):

Kimihiro Igari ◽

Toshifumi Kudo ◽

Takahiro Toyofuku ◽

Takehisa Iwai ◽

Yoshinori Inoue

Keyword(s):

Limb Salvage ◽

Popliteal Artery ◽

Surgical Repair ◽

Graft Patency ◽

Primary Patency ◽

Long Term Results ◽

Open Surgical Repair ◽

Autologous Vein ◽

Medial Approach

The aim of this study was to evaluate the long-term outcomes of the surgical repair of popliteal artery aneurysms (PAAs), and to analyze the factors associated with graft patency. Between January 1980 and December 2013, 45 limbs were subjected to open surgical repair at Tokyo Medical and Dental Hospital. We retrospectively examined the patients' clinical characteristics, clinical symptoms, and aneurysm-related anatomy. Surgical procedures were performed through a posterior or medial approach using autologous vein or prosthetic graft. Surgical outcomes were evaluated by postoperative mortality, postoperative morbidity, graft patency, and limb salvage. During the study period, 45 limbs (35 patients; mean age, 60 years) underwent open surgical repair. A total of 25 limbs were treated through a posterior approach using 23 autologous vein grafts (AVGs) and 2 expanded polytetrafluoroethylene (ePTFE) grafts. The other 20 limbs were treated through a medial approach using 13 AVGs and 7 ePTFE grafts. During the mean follow-up period of 65 months, the primary patency rates at 1, 3, and 5 years were 88.0%, 75.7%, and 75.7%, respectively, and the limb salvage rates at 1, 3, and 5 years were 97.1%, 91.4%, and 91.4%, respectively. In the univariate analysis, the ligation and bypass grafting affected the primary patency rate significantly, and the ePTFE graft was associated with a poor primary patency in the multivariate analysis (hazard ratio, 17.8). The use of resection or endoaneurysmorrhaphy for PAAs and graft interposition with an AVG might be more effective for the open repair of PAAs.

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