Current overview on dental stem cells applications in regenerative dentistry

Angiogenesis is a broad spread term of high interest in regenerative medicine and tissue engineering including the dental field. In the last two decades, researchers worldwide struggled to find the best ways to accelerate healing, stimulate soft, and hard tissue remodeling. Stem cells, growth factors, pathways, signals, receptors, genetics are just a few words that describe this area in medicine. Dental implants, bone and soft tissue regeneration using autologous grafts, or xenografts, allografts, their integration and acceptance rely on their material properties. However, the host response, through its vascularization, plays a significant role. The present paper aims to analyze and organize the latest information about the available dental stem cells, the types of growth factors with pro-angiogenic effect and the possible therapeutic effect of enhanced angiogenesis in regenerative dentistry.

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Use of dental stem cells in regenerative dentistry: A possible alternative

Translational Research ◽

10.1016/j.trsl.2011.07.008 ◽

2011 ◽

Vol 158 (6) ◽

pp. 385-386 ◽

Cited By ~ 5

Author(s):

F.J. Rodríguez-Lozano ◽

J.M. Moraleda

Keyword(s):

Stem Cells ◽

Dental Stem Cells ◽

Regenerative Dentistry

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Stem Cell in Dentistry – Potential Contributions, Challenges and Future

International Journal of Emerging Research in Management and Technology ◽

10.23956/ijermt.v6i10.67 ◽

2017 ◽

Vol 6 (10) ◽

pp. 55

Author(s):

Tejinder Kaur

Keyword(s):

Stem Cells ◽

Stem Cell ◽

Soft Tissues ◽

Donor Site ◽

Donor Site Morbidity ◽

Loss Of Function ◽

Dental Stem Cells ◽

Separate Branch ◽

Regenerative Dentistry ◽

Orofacial Region

Stem cells are unspecialised and unclassified cells but their unique property “pluripotency” makes them special because it has opened the new doors of opportunities and possibilities in the field of dentistry and regenerative medicine to regenerate different organs and tissues. Currently, several studies are undergoing on dental stem cells (SCs) to find out their possible uses in oromaxillofacial region and various stem cells have already been identified for their application in orofacial region. Therefore, a new separate branch of dentistry names as “Regenerative Dentistry” is emerging very fast as dental stem cells offer a lot of benefits over outdated procedures andhave the ability to replace the old restorative techniques of repairing oromaxillofacial trauma which involve disadvantages like scarring, loss of function of replaced part, infection and donor site morbidity with early and late complications [1]. Although oromaxillofacial region is difficult to repair because of its complex anatomical structure but undoubtedly,from past few decades, regeneration of this region using stem cell therapy has also fascinated the entire world of stem cell biologists, molecular biologists, geneticists, clinicians and dentists to discover new advancements in the field of craniofacial engineering[2]. Clearly, future of dentistry lies in stem-cell based powerful therapeutic approach which can potentially transform the reparative and regeneration process of defective hard and soft tissues in orofacial region.

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Human Amniotic Membrane as a Matrix for Endothelial Differentiation of VEGF-Treated Dental Stem Cells

Cellular and Molecular Bioengineering ◽

10.1007/s12195-019-00596-x ◽

2019 ◽

Vol 12 (6) ◽

pp. 599-613 ◽

Cited By ~ 1

Author(s):

Siti Nurnasihah Md Hashim ◽

Muhammad Fuad Hilmi Yusof ◽

Wafa’ Zahari ◽

Hamshawagini Chandra ◽

Khairul Bariah Ahmad Amin Noordin ◽

...

Keyword(s):

Stem Cells ◽

Amniotic Membrane ◽

Endothelial Differentiation ◽

Human Amniotic Membrane ◽

Dental Stem Cells

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Immunomodulatory properties and in vivo osteogenesis of human dental stem cells from fresh and cryopreserved dental follicles

Differentiation ◽

10.1016/j.diff.2015.10.001 ◽

2015 ◽

Vol 90 (1-3) ◽

pp. 48-58 ◽

Cited By ~ 12

Author(s):

Young-Hoon Kang ◽

Hye-Jin Lee ◽

Si-Jung Jang ◽

June-Ho Byun ◽

Jong-Sil Lee ◽

...

Keyword(s):

Stem Cells ◽

Dental Stem Cells ◽

Immunomodulatory Properties

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Today Prospects for Tissue Engineering Therapeutic Approach in Dentistry

The Scientific World JOURNAL ◽

10.1155/2014/151252 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Maurizio Bossù ◽

Andrea Pacifici ◽

Daniele Carbone ◽

Gianluca Tenore ◽

Gaetano Ierardo ◽

...

Keyword(s):

Tissue Engineering ◽

Stem Cells ◽

Current Knowledge ◽

Dental Stem Cells ◽

Therapeutic Tool ◽

Exponential Increase ◽

Major Interest ◽

Adult Mesenchymal Stem Cells ◽

Therapeutic Protocols ◽

Near Future

In dental practice there is an increasing need for predictable therapeutic protocols able to regenerate tissues that, due to inflammatory or traumatic events, may suffer from loss of their function. One of the topics arising major interest in the research applied to regenerative medicine is represented by tissue engineering and, in particular, by stem cells. The study of stem cells in dentistry over the years has shown an exponential increase in literature. Adult mesenchymal stem cells have recently been isolated and characterized from tooth-related tissues and they might represent, in the near future, a new gold standard in the regeneration of all oral tissues. The aim of our review is to provide an overview on the topic reporting the current knowledge for each class of dental stem cells and to identify their potential clinical applications as therapeutic tool in various branches of dentistry.

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