scholarly journals Novel advancements in three-dimensional neural tissue engineering and regenerative medicine

2015 ◽  
Vol 10 (3) ◽  
pp. 352 ◽  
Author(s):  
RichardJ McMurtrey
RSC Advances ◽  
2019 ◽  
Vol 9 (63) ◽  
pp. 36838-36848
Author(s):  
Negar Mansouri ◽  
Said F. Al-Sarawi ◽  
Jagan Mazumdar ◽  
Dusan Losic

In this study, a bio-fabrication method has been developed for the preparation of 3D graphene–alginate composite scaffolds with great potential for neural tissue engineering.


2016 ◽  
Vol 4 (5) ◽  
pp. 768-784 ◽  
Author(s):  
Stephanie Knowlton ◽  
Yongku Cho ◽  
Xue-Jun Li ◽  
Ali Khademhosseini ◽  
Savas Tasoglu

Three-dimensional neural tissue engineering has significantly advanced the development of neural disease models and replacement tissues for patients by leveraging the unique capabilities of stem cells.


2005 ◽  
Vol 227 (1) ◽  
pp. 327-334 ◽  
Author(s):  
Wu Ma ◽  
Silvia Chen ◽  
Wendy Fitzgerald ◽  
Dragan Maric ◽  
Hsingch J. Lin ◽  
...  

Polymers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 3876
Author(s):  
Diana María Osorio-Londoño ◽  
José Rafael Godínez-Fernández ◽  
Ma. Cristina Acosta-García ◽  
Juan Morales-Corona ◽  
Roberto Olayo-González ◽  
...  

Promising strategies for neural tissue engineering are based on the use of three-dimensional substrates for cell anchorage and tissue development. In this work, fibrillar scaffolds composed of electrospun randomly- and aligned-oriented fibers coated with plasma synthesized pyrrole polymer, doped and undoped with iodine, were fabricated and characterized. Infrared spectroscopy, thermogravimetric analysis, and X-ray diffraction analysis revealed the functional groups and molecular integration of each scaffold, as well as the effect of plasma polymer synthesis on crystallinity. Scanning microscopy imaging demonstrated the porous fibrillar micrometric structure of the scaffolds, which afforded adhesion, infiltration, and survival for the neural cells. Orientation analysis of electron microscope images confirmed the elongation of neurite-like cell structures elicited by undoped plasma pyrrole polymer-coated aligned scaffolds, without any biochemical stimuli. The MTT colorimetric assay validated the biocompatibility of the fabricated composite materials, and further evidenced plasma pyrrole polymer-coated aligned scaffolds as permissive substrates for the support of neural cells. These results suggest plasma synthesized pyrrole polymer-coated aligned scaffolds are promising materials for tissue engineering applications.


2017 ◽  
Vol 5 (10) ◽  
pp. 2024-2034 ◽  
Author(s):  
Shuping Wang ◽  
Shui Guan ◽  
Jianqiang Xu ◽  
Wenfang Li ◽  
Dan Ge ◽  
...  

Engineering scaffolds with excellent electro-activity is increasingly important in tissue engineering and regenerative medicine.


2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Khadijeh Zeinali ◽  
Mohammad Taghi Khorasani ◽  
Alimorad Rashidi ◽  
Morteza Daliri Jouparid

: The neural tissue engineering has been designed as a subset of tissue engineering for treating congenital malformations and accident injuries, particularly for individuals requiring tissue grafting. Such transplants, usually performed as autografting, can often not meet the requirements of an effective scaffold used in nerve tissue engineering. A novel neural tissue scaffold was introduced here to solve the problem concerning the reduced graphene oxide. The three-dimensional graphene oxide in the neural canal restricts the formation of fibroglandular tissues and facilities neural stem cell proliferation and growth. In these techniques, graphene oxide aerogel was initially made. Then, the freeze-drying process was used to fix the geometry of reduced graphene oxide hydrogels prepared using graphene oxide dispersion and ethylenediamine and gain aerogels. The X-ray diffraction patterns, FTIR and morphological related to samples were examined, followed by conducting in-vitro micropropagation and 4, 6-diamidino-2-phenylindol (DAPI) staining in fibroblast and P19 cultures. The results from immunofluorescence staining demonstrated the neural differentiation of P19 cells. It can be concluded that most cells attached to and differentiated on the scaffold surface and axons can penetrate randomly through them. Finally, the three-dimensional graphene oxide was proposed as an ideal alternative to be used in neural tissue engineering.


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