scholarly journals Preparation of polypyrrole-embedded electrospun poly(lactic acid) nanofibrous scaffolds for nerve tissue engineering

2016 ◽  
Vol 11 (10) ◽  
pp. 1644 ◽  
Author(s):  
Xiao-dan Sun ◽  
Jiang Peng ◽  
Jun-feng Zhou ◽  
Yi-guo Wang ◽  
Liang Cheng ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Nerve Tissue ◽  
Poly Lactic Acid ◽  
Nanofibrous Scaffolds ◽  
Nerve Tissue Engineering

scholarly journals Tailoring Nano-Porous Surface of Aligned Electrospun Poly (L-Lactic Acid) Fibers for Nerve Tissue Engineering

2021 ◽  
Vol 22 (7) ◽  
pp. 3536
Author(s):  
Hongyun Xuan ◽  
Biyun Li ◽  
Feng Xiong ◽  
Shuyuan Wu ◽  
Zhuojun Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Bacterial Adhesion ◽  
Bacterial Colonization ◽  
Cellular Responses ◽  
Surface Structures ◽  
Porous Surface ◽  
Nerve Tissue ◽  
Proliferation And Differentiation ◽  
Nerve Tissue Engineering

Despite the existence of many attempts at nerve tissue engineering, there is no ideal strategy to date for effectively treating defective peripheral nerve tissue. In the present study, well-aligned poly (L-lactic acid) (PLLA) nanofibers with varied nano-porous surface structures were designed within different ambient humidity levels using the stable jet electrospinning (SJES) technique. Nanofibers have the capacity to inhibit bacterial adhesion, especially with respect to Staphylococcus aureus (S. aureus). It was noteworthy to find that the large nano-porous fibers were less detrimentally affected by S. aureus than smaller fibers. Large nano-pores furthermore proved more conducive to the proliferation and differentiation of neural stem cells (NSCs), while small nano-pores were more beneficial to NSC migration. Thus, this study concluded that well-aligned fibers with varied nano-porous surface structures could reduce bacterial colonization and enhance cellular responses, which could be used as promising material in tissue engineering, especially for neuro-regeneration.

Electrical Stimulation of Nerve Cells Using Conductive Nanofibrous Scaffolds for Nerve Tissue Engineering

2009 ◽  
Vol 15 (11) ◽  
pp. 3605-3619 ◽  
Author(s):  
Laleh Ghasemi-Mobarakeh ◽  
Molamma P. Prabhakaran ◽  
Mohammad Morshed ◽  
Mohammad Hossein Nasr-Esfahani ◽  
Seeram Ramakrishna
Keyword(s):  
Tissue Engineering ◽  
Electrical Stimulation ◽  
Nerve Cells ◽  
Nerve Tissue ◽  
Nanofibrous Scaffolds ◽  
Nerve Tissue Engineering ◽  
Stimulation Of Nerve ◽  
Stimulation Of

Electrospun poly(ɛ-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering

Biomaterials ◽  
2008 ◽  
Vol 29 (34) ◽  
pp. 4532-4539 ◽  
Author(s):  
Laleh Ghasemi-Mobarakeh ◽  
Molamma P. Prabhakaran ◽  
Mohammad Morshed ◽  
Mohammad-Hossein Nasr-Esfahani ◽  
Seeram Ramakrishna
Keyword(s):  
Tissue Engineering ◽  
Nerve Tissue ◽  
Nanofibrous Scaffolds ◽  
Nerve Tissue Engineering

scholarly journals Poly(lactic acid) nanofibrous scaffolds for tissue engineering

2016 ◽  
Vol 107 ◽  
pp. 206-212 ◽  
Author(s):  
Marco Santoro ◽  
Sarita R. Shah ◽  
Jennifer L. Walker ◽  
Antonios G. Mikos
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Poly Lactic Acid ◽  
Nanofibrous Scaffolds

Surface modified electrospun nanofibrous scaffolds for nerve tissue engineering

2008 ◽  
Vol 19 (45) ◽  
pp. 455102 ◽  
Author(s):  
Molamma P Prabhakaran ◽  
J Venugopal ◽  
Casey K Chan ◽  
S Ramakrishna
Keyword(s):  
Tissue Engineering ◽  
Nerve Tissue ◽  
Nanofibrous Scaffolds ◽  
Nerve Tissue Engineering ◽  
Surface Modified

scholarly journals Fabrication and evaluation of porous and conductive nanofibrous scaffolds for nerve tissue engineering

2021 ◽  
Vol 32 (4) ◽  
Author(s):  
Yasaman Pooshidani ◽  
Nastaran Zoghi ◽  
Mina Rajabi ◽  
Masoumeh Haghbin Nazarpak ◽  
Zahra Hassannejad
Keyword(s):  
Tissue Engineering ◽  
Nerve Repair ◽  
Average Diameter ◽  
Nerve Tissue ◽  
Neural Cells ◽  
Implantable Medical Devices ◽  
Angle Measurements ◽  
Nanofibrous Scaffolds ◽  
Nerve Tissue Engineering ◽  
Controlled Porosity

AbstractPeripheral nerve repair is still one of the major clinical challenges which has received a great deal of attention. Nerve tissue engineering is a novel treatment approach that provides a permissive environment for neural cells to overcome the constraints of repair. Conductivity and interconnected porosity are two required characteristics for a scaffold to be effective in nerve regeneration. In this study, we aimed to fabricate a conductive scaffold with controlled porosity using polycaprolactone (PCL) and chitosan (Chit), FDA approved materials for the use in implantable medical devices. A novel method of using tetrakis (hydroxymethyl) phosphonium chloride (THPC) and formaldehyde was applied for in situ synthesis of gold nanoparticles (AuNPs) on the scaffolds. In order to achieve desirable porosity, different percentage of polyethylene oxide (PEO) was used as sacrificial fiber. Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FE-SEM) results demonstrated the complete removing of PEO from the scaffolds after washing and construction of interconnected porosities, respectively. Elemental and electrical analysis revealed the successful synthesis of AuNPs with uniform distribution and small average diameter on the PCL/Chit scaffold. Contact angle measurements showed the effect of porosity on hydrophilic properties of the scaffolds, where the porosity of 75–80% remarkably improved surface hydrophilicity. Finally, the effect of conductive nanofibrous scaffold on Schwann cells morphology and vaibility was investigated using FE-SEM and MTT assay, respectively. The results showed that these conductive scaffolds had no cytotoxic effect and support the spindle-shaped morphology of cells with elongated process which are typical of Schwann cell cultures.

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