scholarly journals Multiple hurdle mechanism and blood-brain barrier in epilepsy: glucocorticoid receptor-heat shock proteins on drug regulation

2021 ◽  
Vol 16 (12) ◽  
pp. 2427
Author(s):  
Chaitali Ghosh ◽  
Aneesha Achar
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Glucocorticoid Receptor ◽  
Blood Brain Barrier ◽  
Drug Regulation ◽  
Brain Barrier ◽  
Blood Brain ◽  
Shock Proteins

scholarly journals Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy

2020 ◽  
Vol 57 (11) ◽  
pp. 4511-4529
Author(s):  
Mohammed Hossain ◽  
Sherice Williams ◽  
Lisa Ferguson ◽  
William Bingaman ◽  
Arnab Ghosh ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Glucocorticoid Receptor ◽  
Drug Resistant ◽  
Brain Endothelial Cell ◽  
Drug Resistant Epilepsy ◽  
Shock Proteins

Inhibition of Proteasomal Glucocorticoid Receptor Degradation Restores Dexamethasone-Mediated Stabilization of the Blood–Brain Barrier After Traumatic Brain Injury*

2013 ◽  
Vol 41 (5) ◽  
pp. 1305-1315 ◽  
Author(s):  
Serge C. Thal ◽  
Eva-Verena Schaible ◽  
Winfried Neuhaus ◽  
David Scheffer ◽  
Moritz Brandstetter ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Glucocorticoid Receptor ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Disruption of Glial Ca2+ Oscillations at the Drosophila Blood-Brain Barrier Predisposes to Seizure-Like Behavior

2020 ◽  
Author(s):  
Shirley Weiss ◽  
Lauren C. Clamon ◽  
Julia E. Manoim ◽  
Kiel G. Ormerod ◽  
Moshe Parnas ◽  
...  
Keyword(s):  
Heat Shock ◽  
Blood Brain Barrier ◽  
Neuronal Development ◽  
Brain Barrier ◽  
Oscillatory Activity ◽  
Distinct Population ◽  
Diverse Range ◽  
Blood Brain ◽  
And Function ◽  
The Brain

AbstractGlia play key roles in regulating multiple aspects of neuronal development and function from invertebrates to humans. We recently found microdomain Ca2+ signaling in Drosophila cortex glia and astrocytes regulate extracellular K+ buffering and neurotransmitter uptake, respectively. Here we identify a role for ER store-operated Ca2+ entry (SOCE) in perineurial glia (PG), a distinct population that contributes to the blood-brain barrier (BBB). PG show a diverse range of Ca2+ oscillatory activity that varies based on their locale within the brain. Unlike cortex glia and astrocytes, PG Ca2+ oscillations do not require extracellular Ca2+ and are blocked by inhibition of SOCE or gap junctions. Disruption of these components triggers heat shock and mechanical-induced seizure-like episodes without effecting PG morphology or large molecule BBB permeability. These findings indicate SOCE-mediated Ca2+ oscillations in PG increase the susceptibility of seizure-like episodes in Drosophila, providing an additional link between glial Ca2+ signaling and neuronal activity.

Immunophilins, Heat Shock Proteins, and Glucocorticoid Receptor Actionsin Vivo

Methods ◽  
1996 ◽  
Vol 9 (2) ◽  
pp. 188-200 ◽  
Author(s):  
Edwin R. Sánchez ◽  
Yang-Min Ning
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Glucocorticoid Receptor ◽  
Shock Proteins
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