scholarly journals High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk

2016 ◽  
Vol 20 (5) ◽  
pp. 656 ◽  
Author(s):  
Lopamudra Ray ◽  
StephenR James ◽  
Kandasamy Ravichandran ◽  
SunilKumar Nanda
Keyword(s):  
Cardiovascular Disease ◽  
Subclinical Hypothyroidism ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Atherogenic Index ◽  
Atherogenic Index Of Plasma

Metabolic cardiovascular disease risk factors and their clustering in subclinical hypothyroidism

2010 ◽  
Vol 72 (5) ◽  
pp. 689-695 ◽  
Author(s):  
Kiyoto Ashizawa ◽  
Misa Imaizumi ◽  
Toshiro Usa ◽  
Tan Tominaga ◽  
Nobuko Sera ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Subclinical Hypothyroidism ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factors

scholarly journals Association of Apolipoprotein E Polymorphism with Adipokines and Cardiovascular Disease Risk in Rheumatoid Arthritis Patients

Life ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 330
Author(s):  
Yi-Ming Chen ◽  
Po-Ku Chen ◽  
Ching-Kun Chang ◽  
Chi-Chen Lin ◽  
Hsin-Hua Chen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Disease ◽  
Apolipoprotein E ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Cvd Risk ◽  
Tnf Α ◽  
Apoe Genotypes

Apolipoprotein E (ApoE) polymorphism and adipokines are linked to atherosclerosis. We aimed to investigate the associations of apoE genotypes with adipokines, inflammatory parameters, and cardiovascular disease (CVD) risks in rheumatoid arthritis (RA) patients. We enrolled 152 RA patients and 49 healthy control (HC) subjects. The apoE genotyping was determined by a polymerase chain reaction, while plasma levels of adipokines and inflammatory cytokines were measured with ELISA. Although apoE genotypes distributions were indistinguishable between RA patients and HC, we found significantly higher levels of apoE and adipokines in RA patients compared with HC. RA patients with ε2ε3 genotype had lower levels of TNF-α, IL-6, resistin, and visfatin, but higher leptin levels compared with ε3ε3 genotype patients. Patients with ε3ε4 genotype had significantly higher low-density lipoprotein-cholesterol (LDL-C) levels and atherogenic index scores compared with ε2ε3 genotype carriers. Moreover, patients with ε2ε3 genotype had significantly lower 10-year CVD risk than ε3ε3 or ε3ε4 genotype patients. ε3ε4 genotype and adiponectin levels were independent predictors of a high 10-year CVD risk. RA patients with ε2ε3 genotype are associated with lower levels of TNF-α, IL-6, resistin, visfatin, and CVD risk, while RA patients with ε3ε4 genotype exhibited higher levels of LDL-C, insulin resistance, and higher CVD risks.

scholarly journals NDSP-12: Atherogenic index of plasma as a useful marker of cardiovascular disease risk among Pakistani individuals; a study from the second National Diabetes Survey of Pakistan (NDSP) 2016-2017

2021 ◽  
Author(s):  
Asher Fawwad ◽  
Yasir Mahmood ◽  
Saima Askari ◽  
Anum Butt ◽  
Abdul Basit ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Atherogenic Index ◽  
Risk Category ◽  
Oral Glucose ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Atherogenic Index Of Plasma ◽  
Diabetes Survey

Aim To assess the correlation between atherogenic index of plasma (AIP) and cardiovascular disease (CVD) risk factors. Methodology This is a sub study of the second National Diabetes Survey of Pakistan (NDSP) 2016–2017, an epidemiological survey including people of > 20 years of age and both genders in all four provinces of Pakistan. Out of 213 clusters, twenty-seven clusters were selected from all over the Pakistan. Households were identified and selected members of every 10th household were counseled to come to the campsite after observing an overnight fast. Standardized techniques were used for measuring height, weight, BMI, waist circumference, and blood pressure. Standard methods were used for analyzing biochemical parameters including oral glucose tolerance test, lipid profile and various lipid derived parameter/ratios were calculated. The AIP was calculated by using formula log10 (TG/HDL) for all survey participants. Statistical analyses were conducted by using statistical package for social sciences, version 20. Results A total of 7351 people (2877 males and 4201females) were selected for this sub-analysis after fulfilling the inclusion criteria. Overall AIP score was calculated as 0.74±0.31 and according to the AIP risk categorization, the majority 6996 (95.2%) fell in the high-risk category of developing CVD, whereas 258(3.5%) were in moderate and only 97(1.3%) people were found in low-risk category. Multiple logistic regression analyses showed male gender and diabetes as risk factor for developing CVD based on AIP score. Furthermore, various lipid derived parameters LDL-C and HDL-C, TG and HDL-C, lipoprotein combined index (LCI) were shown strong correlation with AIP. Conclusion The significant association between AIP and CVD risk factors exists and high levels of AIP in Pakistani population may be an alarming sign in developing cardiovascular disease.

scholarly journals Salusin-β in patients with subclinical hypothyroidism and low to moderate cardiovascular disease risk

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Hassan Hassanin ◽  
Hala Abomandour ◽  
Ahmad Hassaneen ◽  
Alaa Farag ◽  
Amany Sediq
Keyword(s):  
Cardiovascular Disease ◽  
Subclinical Hypothyroidism ◽  
Disease Risk ◽  
Cardiovascular Disease Risk

scholarly journals Novel Lipid Indices as a Better Marker of Cardiovascular Disease Risk in Postmenopausal Women

2017 ◽  
Vol 21 (1) ◽  
pp. 38-41
Author(s):  
Muruga Sirigere ◽  
S Meera
Keyword(s):  
Cardiovascular Disease ◽  
Lipid Profile ◽  
Postmenopausal Women ◽  
Plasma Lipids ◽  
Disease Risk ◽  
Risk Index ◽  
Cardiovascular Disease Risk ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Hormonal Changes

ABSTRACT Introduction Cardiovascular disease (CVD) is the major leading cause of mortality in men and women around the globe. The incidence of CVD increases with age in both the sexes, whereas it has been noted that there is a marked increase in risk among women after menopause. The hormonal changes associated with the menopause like low level of plasma estrogen and marked increase in follicle stimulating hormone levels exert a significant effect on metabolism of plasma lipids and lipoproteins leading to atherosclerosis, thereby increasing the risk of CVD in postmenopausal women. Objectives To study the lipid profile parameters and to calculate and compare the lipid indices with lipid profile parameters in pre- and postmenopausal women. Materials and methods The study group included 90 women comprising 45 postmenopausal (cases) and 45 premenopausal (control) women. To estimate lipid profile, enzymatic method was used and for calculation of lipid indices appropriate formula was used. Results Altered lipid profile was observed in postmenopausal women, but it was not statistically significant. Atherogenic Index of Plasma, Castelli's risk index-I, atherogenic coefficient, and nonhigh-density lipoprotein cholesterol were significantly increased in postmenopausal women compared with premenopausal women, but there was no significant increase in Castelli's risk index-II. Conclusion Lipid indices may be considered as a better and cost-effective tool in assessing the risk of CVD in postmenopausal women. How to cite this article Sirigere M, Meera S. Novel Lipid Indices as a Better Marker of Cardiovascular Disease Risk in Postmenopausal Women. Indian J Med Biochem 2017;21(1):38-41.

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