scholarly journals Rare case of an isolated myeloid sarcoma presenting as dysphagia

2018 ◽  
Vol 04 (01) ◽  
pp. 030-033
Author(s):  
Rishu Sangal ◽  
Vivek Mahawar ◽  
Ankush Jajodia ◽  
Himanshu Mahanthi ◽  
Venkata Koyyala
Keyword(s):  
Myeloid Leukemia ◽  
Rare Case ◽  
De Novo ◽  
Case Reports ◽  
Bone Marrow Involvement ◽  
Myeloid Sarcoma ◽  
Response To Treatment ◽  
Hematological Disease ◽  
Present Case Report ◽  
Rare Site

AbstractMyeloid sarcoma (MS) is an unusual neoplasm whose understanding is principally based on the case reports and/or theoretically dated contributions. MS represents the proliferation of myeloblasts of acute myeloid leukemia (AML) at extramedullary sites. While extramedullary involvement in AML is unusual in itself, isolated (de novo) MSs that is MSs devoid of any bone marrow involvement are exceptionally rare. The present case report study expands the gamut of our acquaintance showing that MS can occur de novo, with no apparent sign or symptom of concomitant hematological disease and may show a significant response to treatment this may be omitted here. This case reports described a middle-aged male presenting as with dysphagia with isolated MS in the stomach, a very rare site.

scholarly journals Spine Myeloid Sarcoma: A Case Series with Review of Literature

2021 ◽  
Vol 10 (04) ◽  
pp. 251-254
Author(s):  
Kajal Shah ◽  
Harsha Panchal ◽  
Apurva Patel
Keyword(s):  
Myeloid Leukemia ◽  
De Novo ◽  
Correct Diagnosis ◽  
Relevant Literature ◽  
Bone Marrow Involvement ◽  
Case Series ◽  
Diagnostic Algorithm ◽  
Myeloid Sarcoma ◽  
Diagnostic Challenge ◽  
Extramedullary Tumor

AbstractMyeloid sarcoma (MS) is a malignant extramedullary tumor consisting of immature cells of myeloid origin. It may precede, present concurrently or follow acute myeloid leukemia (AML) in de novo case or may also be present and might be the only manifestation of recurrent AML, myelodysplastic syndrome, or chronic myeloid leukemia. It frequently involves skin, orbit, bone, periosteum, lymph nodes, and gastrointestinal tract, soft tissue, central nervous system, and testis. Because of its different localization and symptoms, and the lack of diagnostic algorithm, MS is a real diagnostic challenge particularly in patients without initial bone marrow involvement. The correct diagnosis of MS is important for optimum therapy, which is often delayed because of a high misdiagnosis rate. We reported three cases of MS derived from spine presented with back pain, paraplegia, paraparesis, respectively, and reviewed the relevant literature.

scholarly journals GASTROINTESTINAL MYELOID SARCOMA A CASE PRESENTATION AND CRITICAL REVIEW OF THE LITERATURE

2021 ◽  
Vol 13 (1) ◽  
pp. e2021067
Author(s):  
Pouyan Kheirkhah ◽  
Ana M. Avila-Rodriguez ◽  
Bartlomiej Radzik ◽  
Carlos Murga-Zamalloa
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
De Novo ◽  
Abdominal Cavity ◽  
Bone Marrow Involvement ◽  
Myeloid Sarcoma ◽  
Cell Transplant ◽  
Review Of The Literature ◽  
Hematopoietic Stem ◽  
Acute Myeloid

Myeloid sarcomas can be detected in up to 30% of acute myeloid leukemia cases or occur de-novo without bone marrow involvement. The most frequent localization of myeloid sarcomas in the abdominal cavity is the small intestine, and gastric presentations are infrequent, frequently misdiagnosed, and a high level of suspicion should exist when the characteristic histomorphology features are present. The current review features a case report with gastric presentation of myeloid sarcoma in a patient with a diagnosis of acute myeloid leukemia with trisomy 8. In addition, a review of the literature of intestinal type myeloid sarcomas shows that less than 15% of these cases have been reported in the stomach. The most common molecular aberrancy detected in intestinal myeloid sarcomas is the fusion protein CBFB-MYH11. Review of several large studies demonstrates that the presence of myeloid sarcoma does not constitute an independent prognostic factor. The therapeutic approach will be tailored to the specific genetic abnormalities present, and systemic chemotherapy with hematopoietic stem cell transplant are the most efficient strategies.

scholarly journals A Case of Myeloid Sarcoma in the Nasal Cavity Occurred in the Patient with Leukemic Transformation in Myelodysplastic Syndrome

2020 ◽  
Vol 63 (2) ◽  
pp. 81-84
Author(s):  
Dong Hoo Lee ◽  
Sung Yool Park ◽  
Ha Young Park ◽  
Seong Kook Park
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myelodysplastic Syndrome ◽  
Nasal Cavity ◽  
Myeloid Leukemia ◽  
Rare Case ◽  
De Novo ◽  
Myeloid Sarcoma ◽  
Leukemic Transformation ◽  
Normal Architecture ◽  
Acute Myeloid

Myeloid sarcoma is characterized by the presence of myeloid blasts at an extramedullar site that disrupts the normal architecture of the organ. Many of these cases are associated with acute myeloid leukemia, chronic myeloid leukemia, myelodysplastic syndrome, or occur in de novo. It occurs most commonly in skin, lymph node, gastrointestinal tract, bone, soft tissue but, rarely in head and neck; especially in nasal cavity. Therefore, it is often misdiagnosed as a different disease: most commonly as lymphoma. Here we report a rare case of myeloid sarcoma in the nasal cavity that occurred in a patient with leukemic transformation with myelodysplastic syndrome, provided with literature review.

scholarly journals Isolated Gastric Myeloid Sarcoma: A Case Report and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Pankit Vachhani ◽  
Prithviraj Bose
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Myeloid Leukemia ◽  
Bone Marrow Involvement ◽  
Myeloid Sarcoma ◽  
Review Of The Literature ◽  
Aged Woman ◽  
Middle Aged Woman ◽  
Acute Myeloid

Myeloid sarcoma represents the proliferation of myeloblasts of acute myeloid leukemia (AML) at extramedullary sites. While extramedullary involvement in AML is uncommon in itself, isolated myeloid sarcomas, that is, myeloid sarcomas without any bone marrow involvement, are extremely rare and pose a diagnostic and therapeutic challenge. Here, we present the case of a middle-aged woman with isolated myeloid sarcoma in the stomach—an organ seldom involved by this disease. Additionally, the literature on the epidemiology, diagnosis, pathology, prognosis, and therapeutic options in myeloid sarcomas has been reviewed.

scholarly journals Isolated myeloid sarcoma of lumbar spine without bone marrow involvement: a rare case report and treatment dilemma

2021 ◽  
Vol 0 ◽  
pp. 0-0
Author(s):  
Janpreet S. Bhandohal ◽  
Leila Moosavi ◽  
Igor Garcia-Pacheco ◽  
Gian Yakoub ◽  
Rahul D. Polineni ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Case Report ◽  
Lumbar Spine ◽  
Rare Case ◽  
Bone Marrow Involvement ◽  
Myeloid Sarcoma ◽  
Rare Case Report

scholarly journals Extramedullary Monoblastic Sarcoma/Myeloid Sarcoma of Paraspinal Region Without Myeloid Leukemia: A Rare Case Report

2018 ◽  
Vol 150 (suppl_1) ◽  
pp. S49-S50
Author(s):  
Mitul Modi ◽  
Vipulkumar Prajapati ◽  
Irappa Madabhavi ◽  
Himanshu Kavani ◽  
Mansi Shah
Keyword(s):  
Case Report ◽  
Myeloid Leukemia ◽  
Rare Case ◽  
Myeloid Sarcoma ◽  
Rare Case Report

scholarly journals Immunotherapy- (Blinatumomab-) Related Lineage Switch of KMT2A/AFF1 Rearranged B-Lymphoblastic Leukemia into Acute Myeloid Leukemia/Myeloid Sarcoma and Subsequently into B/Myeloid Mixed Phenotype Acute Leukemia

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Rui R. He ◽  
Zacharia Nayer ◽  
Matthew Hogan ◽  
Raymund S. Cuevo ◽  
Kimberly Woodward ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Lymphoblastic Leukemia ◽  
Bone Marrow Involvement ◽  
Bone Marrow Examination ◽  
Myeloid Sarcoma ◽  
Poor Prognostic Factor ◽  
Lineage Switch ◽  
Acute Myeloid

The presence of KMT2A/AFF1 rearrangement in B-lymphoblastic leukemia (B-ALL) is an independent poor prognostic factor and has been associated with higher rate of treatment failure and higher risk of linage switch under therapy. Blinatumomab has shown promising therapeutic results in refractory or relapsed B-ALL; however, it has potential risk of inducing lineage switch, especially in KMT2A/AFF1 rearranged B-ALL into acute myeloid leukemia and/or myeloid sarcoma. We report a 40-year-old female with KMT2A/AFF1-rearranged B-ALL that was refractory to conventional chemotherapy. Following administration of blinatumomab, she developed a breast mass proven to be myeloid sarcoma, in addition to bone marrow involvement by AML. Approximately six weeks after cessation of blinatumomab, a repeat bone marrow examination revealed B/myeloid MPAL.

scholarly journals Long-Lasting Remission in De Novo Breast Myeloid Sarcoma Treated with Decitabine and Radiotherapy

Diagnostics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 84
Author(s):  
Carla Minoia ◽  
Vincenza de Fazio ◽  
Giovanni Scognamillo ◽  
Anna Scattone ◽  
Nicola Maggialetti ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Acute Myeloid Leukemia ◽  
Clinical Outcome ◽  
Disease Control ◽  
Myeloid Leukemia ◽  
De Novo ◽  
Myeloid Sarcoma ◽  
Treatment Modalities ◽  
Adverse Clinical Outcome ◽  
Acute Myeloid

Myeloid sarcoma (MS) represents a rare disease with an adverse clinical outcome for patients not candidate to acute myeloid leukemia (AML)-like chemotherapies. Here we present the case of an elderly patient affected by a bilateral breast localization of MS treated with the hypomethylating agent decitabine associated to radiotherapy. The association of the two treatment modalities has allowed an optimal and long-lasting disease control.

scholarly journals A Rare Case of Myeloid Sarcoma Presenting as an Anorectal Ulcer

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Laxmi Parsa ◽  
Priti Bijpuria ◽  
Daniel Ringold ◽  
David Stein
Keyword(s):  
Immunohistochemical Staining ◽  
Myeloid Leukemia ◽  
Rare Case ◽  
Soft Tissues ◽  
Histochemical Staining ◽  
Myeloid Sarcoma ◽  
Atypical Presentation ◽  
Rare Tumor ◽  
Gastrointestinal Complaint ◽  
Acute Myeloid

Myeloid Sarcoma is a rare tumor composed of myeloblasts occurring at an extramedullary site like bones, or various soft tissues. Myeloid sarcoma may involve the gastrointestinal tract very rarely either solitarily, or occurring simultaneously with acute myeloid leukemia. Its diagnosis is challenging and needs biopsy and immunohistochemical staining. We are describing a case of myeloid sarcoma which presented as a painful anal ulcer mimicking an atypical fissure. Its appearance resembled crohn’s disease on sigmoidoscopy. A biopsy of the ulcer along with histochemical staining led to the diagnosis of myeloid sarcoma. Our case demonstrates the need for aggressive evaluation of any common gastrointestinal complaint with an atypical presentation.

Sign in / Sign up

Export Citation Format

Share Document