Radiation-induced dysphagia and life-threatening stridor in nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC), an uncommon malignancy in Western Countries and Radiotherapy, remains an effective treatment. Its side effects are classified as either immediate or late; postradiation necrosis is as an important late side effect with a strong impact on the prognosis in patients with NPC. We report the case of 65-year-old Caucasian man presenting with a deep necrotic ulcer of the nasopharynx and osteoradionecrosis of the skull base that appeared 3 months after radiotherapy for nasopharyngeal carcinoma. Conservative treatment was applied with surgical management of the ulcer. Clinical and radiological outcomes are presented. Radiotherapy remains a good treatment option with varying degrees of side effects, in particular, postradiation necrosis and ulcer. Multiple options of treatment have been described. However, the surgical management could be indicated in cases of deep ulcer with life-threatening prognosis.

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Machine-Learning-Assisted Radiomic Biomarkers for Early Detection of Radiation-Induced Brain Injury in Nasopharyngeal Carcinoma

SSRN Electronic Journal ◽

10.2139/ssrn.3324730 ◽

2019 ◽

Author(s):

Bin Zhang ◽

Zhouyang Lian ◽

Liming Zhong ◽

Xiao Zhang ◽

Yuhao Dong ◽

...

Keyword(s):

Machine Learning ◽

Brain Injury ◽

Nasopharyngeal Carcinoma ◽

Early Detection ◽

Radiation Induced

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Liver Tolerance to Repeat 90Y-Microsphere Radioembolization

Journal of Medical Devices ◽

10.1115/1.2932344 ◽

2008 ◽

Vol 2 (2) ◽

Author(s):

Patrick McNeillie ◽

Andrew S. Kennedy ◽

William Dezarn ◽

Scott L. Sailer ◽

Mary England ◽

...

Keyword(s):

Liver Function ◽

Liver Tumors ◽

Liver Volume ◽

Dose Calculation ◽

External Beam Radiation ◽

Beam Radiation ◽

Resin Microspheres ◽

Life Threatening ◽

Radiation Induced ◽

And Function

Purpose: Liver tolerance to multiple doses of Y90-microspheres is not known. Many patients (pts) are surviving long enough to be considered for a second and third liver treatments with internal radiation. Materials and Methods: The experience of a single center treating liver tumors with resin Y90-microspheres. Pts that received liver radiation prior to or after resin microsphere therapy were studied. Endpoints were toxicity, tumor response, shunting to lung, and effects on liver volume and function. The delivery activity of microspheres selected was not reduced below BSA dose calculation for patients without prior treatment. All patients received bilobar single session delivery. Results: A total of 38 pts; 14 women, 24 men, treated 6∕2003 to 9∕2006, with 33 pts receiving 2 courses and 5 pts with 3 courses of liver radiation. Retreatment with resin microspheres 26 pts, prior external beam radiation in 7 pts, prior glass microspheres in 2 pts, prior systemic radiotherapy in 2 pts, and prior stereotactic liver radiation in 1 pt. Liver function was stable and adequate in all patients after additional liver radiation, and no pts developed radiation-induced liver dysfunction (RILD) or veno-occlusive disease (VOD). The percentage of shunting to the lung decreased with retreatment. Conclusions: Repeated implantation in the liver with Y90-microspheres is safe in patients that have sufficient liver function and reserve based on known and accepted laboratory parameters already used for selection of microsphere therapy. No acute life-threatening, fatal, or late liver damage was observed, RILD or VOD. No specific dose reduction is recommended for retreatment of the liver.

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The Use of Multiple Foley Balloon Catheters for Treating Life-Threatening Radiation Induced Hemorrhagic Cystitis

Journal of Clinical Case Reports ◽

10.4172/2165-7920.1000899 ◽

2016 ◽

Vol 6 (12) ◽

Author(s):

Wen Ming Chen ◽

Hsien Chih Lin ◽

Chuo Jung Tsai

Keyword(s):

Hemorrhagic Cystitis ◽

Balloon Catheters ◽

Life Threatening ◽

Radiation Induced

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Preliminary Nonclinical Toxicity, Pharmacokinetics, and Pharmacodynamics of ALXN4100TPO, a Thrombopoietin Receptor Agonist, in CD2F1 Mice

International Journal of Toxicology ◽

10.1177/1091581813482336 ◽

2013 ◽

Vol 32 (2) ◽

pp. 100-112 ◽

Cited By ~ 6

Author(s):

Merriline Satyamitra ◽

Eric Lombardini ◽

Tao Peng ◽

Denise Devore ◽

John Graves ◽

...

Keyword(s):

Receptor Agonist ◽

Extramedullary Hematopoiesis ◽

Weight Changes ◽

Hematopoietic Tissue ◽

Platelet Counts ◽

Clinical Observations ◽

Significant Survival ◽

Life Threatening ◽

Radiation Induced ◽

Kg Medium

ALXN4100TPO, a thrombopoietin (TPO) receptor agonist, increases platelets, abrogates radiation-induced thrombocytopenia and affords significant survival benefit to lethally irradiated mice. This preliminary nonclinical safety study assessed effects of a single subcutaneous (sc) administration of ALXN4100TPO in CD2F1 mice randomized into naïve, control antibody (ALXN4200, 100 mg/kg), low (1 mg/kg), medium (10 mg/kg), or high (100 mg/kg) ALXN4100TPO doses. End points included clinical observations, body weight changes, hematology, histopathology, pharmacokinetics, pharmacodynamics by measuring platelet counts, and endogenous TPO (eTPO) levels. Salient findings were prominent increase in platelet counts and end cells of myeloid and lymphoid lineages; elevated megakaryopoiesis in bone marrow; and extramedullary hematopoiesis in spleen and liver. Serum ALXN4100TPO levels were maximum 24 hours after administration, with a half-life of 13 days. Endogenous TPO levels were elevated in 10 and 100 mg/kg ALXN4100TPO-treated groups. In conclusion, ALXN4100TPO (1-100 mg/kg, sc) treatment in CD2F1 mice resulted in profound pharmacological changes in the hematopoietic tissue; however, no life-threatening adverse events were observed.

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