scholarly journals Concurrent Venous Stenting of the Transverse and Occipito-Marginal Sinuses: An Analogy with Parallel Hemodynamic Circuits

2019 ◽  
Vol 10 (02) ◽  
pp. 334-338
Author(s):  
Thomas J. Buell ◽  
Daniel M. S. Raper ◽  
Dale Ding ◽  
Ching-Jen Chen ◽  
Tony R. Wang ◽  
...  

ABSTRACTNonthrombotic intracranial venous occlusive disease (NIVOD) has been implicated in the pathophysiology of idiopathic intracranial hypertension (IIH) and various non-IIH headache syndromes. Endovascular stenting of stenotic, dominant transverse sinuses (TSs) may reduce trans-stenosis pressure gradients, decrease intracranial pressure, and alleviate symptoms in a subset of NIVOD patients. We present a case in which concurrent stenting of the occipito-marginal sinus obliterated the residual trans-stenosis pressure gradient across an initially stented dominant TS. We hypothesize that this observation may be explained using an electric-hydraulic analogy, and that this patient’s dominant TS and occipito-marginal sinus may be modeled as a parallel hemodynamic circuit. Neurointerventionalists should be aware of parallel hemodynamic drainage patterns and consider manometry and possibly additional stenting of stenotic, parallel venous outflow pathways if TS stenting alone fails to obliterate the trans-stenosis pressure gradient.

2014 ◽  
Vol 37 (v1supplement) ◽  
pp. 1 ◽  
Author(s):  
Dale Ding ◽  
Robert M. Starke ◽  
Christopher R. Durst ◽  
R. Webster Crowley ◽  
Kenneth C. Liu

Increasing evidence supports dural venous sinus stenosis as the patho-etiology of pseudotumor cerebri (PTC) in a subset of affected patients. In this video, we demonstrate our technique for 1) diagnostic venous manometry to identify a flow-limiting stenosis of the transverse sinus in a PTC patient; and 2) successful treatment of the patient with venous stenting across the structural and physiological stricture in the dural sinus. The pressure gradient decreased from 20 mmHg pre-stent to 3 mmHg post-stent. In order to further quantify the effect of our intervention, concurrent intracranial pressure monitoring was performed.The video can be found here: http://youtu.be/auxRg17F8yI.


2011 ◽  
Vol 301 (1) ◽  
pp. H48-H60 ◽  
Author(s):  
Michael J. Davis ◽  
Elaheh Rahbar ◽  
Anatoliy A. Gashev ◽  
David C. Zawieja ◽  
James E. Moore

Secondary lymphatic valves are essential for minimizing backflow of lymph and are presumed to gate passively according to the instantaneous trans-valve pressure gradient. We hypothesized that valve gating is also modulated by vessel distention, which could alter leaflet stiffness and coaptation. To test this hypothesis, we devised protocols to measure the small pressure gradients required to open or close lymphatic valves and determine if the gradients varied as a function of vessel diameter. Lymphatic vessels were isolated from rat mesentery, cannulated, and pressurized using a servo-control system. Detection of valve leaflet position simultaneously with diameter and intraluminal pressure changes in two-valve segments revealed the detailed temporal relationships between these parameters during the lymphatic contraction cycle. The timing of valve movements was similar to that of cardiac valves, but only when lymphatic vessel afterload was elevated. The pressure gradients required to open or close a valve were determined in one-valve segments during slow, ramp-wise pressure elevation, either from the input or output side of the valve. Tests were conducted over a wide range of baseline pressures (and thus diameters) in passive vessels as well as in vessels with two levels of imposed tone. Surprisingly, the pressure gradient required for valve closure varied >20-fold (0.1–2.2 cmH2O) as a passive vessel progressively distended. Similarly, the pressure gradient required for valve opening varied sixfold with vessel distention. Finally, our functional evidence supports the concept that lymphatic muscle tone exerts an indirect effect on valve gating.


1997 ◽  
Vol 273 (2) ◽  
pp. H997-H1002 ◽  
Author(s):  
R. E. Drake ◽  
S. Dhother ◽  
R. A. Teague ◽  
J. C. Gabel

Microvascular membranes are heteroporous, so the mean osmotic reflection coefficient for a microvascular membrane (sigma d) is a function of the reflection coefficient for each pore. Investigators have derived equations for sigma d based on the assumption that the protein osmotic pressure gradient across the membrane (delta II) does not vary from pore to pore. However, for most microvascular membranes, delta II probably does vary from pore to pore. In this study, we derived a new equation for sigma d. According to our equation, pore-to-pore differences in delta II increase the effect of small pores and decrease the effect of large pores on the overall membrane osmotic reflection coefficient. Thus sigma d for a heteroporous membrane may be much higher than previously derived equations indicate. Furthermore, pore-to-pore delta II differences increase the effect of plasma protein osmotic pressure to oppose microvascular fluid filtration.


2018 ◽  
Vol 2018 ◽  
pp. 1-26 ◽  
Author(s):  
Gang Zhou ◽  
Lei Qiu ◽  
Wenzheng Zhang ◽  
Jiao Xue

The aim of this paper was to develop a model that can characterize the actual micropore structures in coal and gain an in-depth insight into water’s seepage rules in coal pores under different pressure gradients from a microscopic perspective. To achieve this goal, long-flame coals were first scanned by an X-ray 3D microscope; then, through a representative elementary volume (REV) analysis, the optimal side length was determined to be 60 μm; subsequently, by using Avizo software, the coal’s micropore structures were acquired. Considering that the porosity varies in the same coal sample, this study selected four regions in the sample for an in-depth analysis. Moreover, numerical simulations on water’s seepage behaviors in coal under 30 different pressure gradients were performed. The results show that (1) the variation of the simulated seepage velocity and pressure gradient accorded with Forchheimer’s high-velocity nonlinear seepage rules; (2) the permeability did not necessarily increase with the increase of the effective porosity; (3) in the same model, under different pressure gradients, the average seepage pressure decreased gradually, while the average seepage velocity and average mass flow varied greatly with the increase of the seepage length; and (4) under the same pressure gradient, the increase of the average mass flow from the inlet to the outlet became more significant under a higher inlet pressure.


Author(s):  
Frank J. Aldrich

A physics-based approach is employed and a new prediction tool is developed to predict the wavevector-frequency spectrum of the turbulent boundary layer wall pressure fluctuations for subsonic airfoils under the influence of adverse pressure gradients. The prediction tool uses an explicit relationship developed by D. M. Chase, which is based on a fit to zero pressure gradient data. The tool takes into account the boundary layer edge velocity distribution and geometry of the airfoil, including the blade chord and thickness. Comparison to experimental adverse pressure gradient data shows a need for an update to the modeling constants of the Chase model. To optimize the correlation between the predicted turbulent boundary layer wall pressure spectrum and the experimental data, an optimization code (iSIGHT) is employed. This optimization module is used to minimize the absolute value of the difference (in dB) between the predicted values and those measured across the analysis frequency range. An optimized set of modeling constants is derived that provides reasonable agreement with the measurements.


Author(s):  
Jeffrey P. Bons ◽  
Stephen T. McClain

Experimental measurements of heat transfer (St) are reported for low speed flow over scaled turbine roughness models at three different freestream pressure gradients: adverse, zero (nominally), and favorable. The roughness models were scaled from surface measurements taken on actual, in-service land-based turbine hardware and include samples of fuel deposits, TBC spallation, erosion, and pitting as well as a smooth control surface. All St measurements were made in a developing turbulent boundary layer at the same value of Reynolds number (Rex≅900,000). An integral boundary layer method used to estimate cf for the smooth wall cases allowed the calculation of the Reynolds analogy (2St/cf). Results indicate that for a smooth wall, Reynolds analogy varies appreciably with pressure gradient. Smooth surface heat transfer is considerably less sensitive to pressure gradients than skin friction. For the rough surfaces with adverse pressure gradient, St is less sensitive to roughness than with zero or favorable pressure gradient. Roughness-induced Stanton number increases at zero pressure gradient range from 16–44% (depending on roughness type), while increases with adverse pressure gradient are 7% less on average for the same roughness type. Hot-wire measurements show a corresponding drop in roughness-induced momentum deficit and streamwise turbulent kinetic energy generation in the adverse pressure gradient boundary layer compared with the other pressure gradient conditions. The combined effects of roughness and pressure gradient are different than their individual effects added together. Specifically, for adverse pressure gradient the combined effect on heat transfer is 9% less than that estimated by adding their separate effects. For favorable pressure gradient, the additive estimate is 6% lower than the result with combined effects. Identical measurements on a “simulated” roughness surface composed of cones in an ordered array show a behavior unlike that of the scaled “real” roughness models. St calculations made using a discrete-element roughness model show promising agreement with the experimental data. Predictions and data combine to underline the importance of accounting for pressure gradient and surface roughness effects simultaneously rather than independently for accurate performance calculations in turbines.


2021 ◽  
Author(s):  
Nikolay Baryshnikov ◽  
Evgeniy Zenchenko ◽  
Sergey Turuntaev

<p>Currently, a number of studies showing that the injection of fluid into the formation can cause induced seismicity. Usually, it is associated with a change in the stress-strain state of the reservoir during the pore pressure front propagation. Modeling this process requires knowledge of the features of the filtration properties of reservoir rocks. Many researchers note the fact that the measured permeability of rock samples decreases at low pressure gradients. Among other things, this may be due to the formation of boundary adhesion layers with altered properties at the interfaces between the liquid and solid phases. The characteristic thickness of such layer can be fractions of a micron, and the effect becomes significant when filtering the fluid in rocks with a comparable characteristic pore size. The purpose of this work was to study the filtration properties of rock samples with low permeability at low flow rates. Laboratory modeling of such processes is associated with significant technical difficulties, primarily with the accuracy limit of measuring instruments when approaching zero speed values. The technique used by us to conduct the experiment and data processing allows us to study the dependence of the apparent permeability on the pore pressure gradient in the range of 0.01 MPa/m, which is comparable to the characteristic pressure gradients during the development of oil fields. In the course of the study, we carried out laboratory experiments on limestone core samples, during which the dependencies of their apparent permeability on the pore pressure gradient were obtained. We observed a significant decrease in their permeability at low flow rates. In the course of analyzing the experimental results, we proposed that a decrease in apparent permeability may occur due to the effect of even a small amount of residual gas in the pore space of the samples. This has been confirmed by additional experiments. The possibility of clogging of core sample pore space must be considered when conducting when conducting laboratory studies of the core apparent permeability.</p>


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