Memorable clinical experiences, all in one year at Queen Square, London, United Kingdom (1968-1969): A tribute to Neurology legends

2017 ◽  
Vol 65 (5) ◽  
pp. 944 ◽  
Author(s):  
K Srinivasan
Keyword(s):  
United Kingdom ◽  
Clinical Experiences ◽  
One Year

scholarly journals A Framework to Assess Fiscal Vulnerability: Empirical Evidence for European Union Countries

2018 ◽  
Vol 10 (7) ◽  
pp. 2482 ◽  
Author(s):  
Andreea Stoian ◽  
Laura Obreja Brașoveanu ◽  
Iulian Brașoveanu ◽  
Bogdan Dumitrescu
Keyword(s):  
European Union ◽  
United Kingdom ◽  
Sovereign Debt ◽  
Debt Crisis ◽  
First Year ◽  
Annual Data ◽  
Budget Balance ◽  
European Union Countries ◽  
One Year ◽  
Fiscal Distress

Following the financial crisis of 2007 and the sovereign debt crisis in 2010 that affected the soundness and reduced the strength of public finance in European countries, there has been a growing interest in developing methodologies to the help assess and signal the vulnerability of fiscal policy. Therefore, the aim of this study is to develop a new framework (V-L-D) to assess fiscal vulnerability. V-L-D represents a new methodology on the measurement of fiscal vulnerability that relies on the assumption that vulnerability can occur even during calm times. In comparison with previous methodologies that studied fiscal vulnerability around crisis and fiscal distress times, our framework investigates fiscal vulnerability near fiscal adjustments episodes. Our methodology relies on two distinct indicators: one showing the vulnerabilities indicated by the level of the cyclically adjusted budget balance and distance-to-stability, and one showing the vulnerabilities pointed out through the changes of the cyclically adjusted budget balance and public debt. V-L-D is able to classify fiscal vulnerability into five distinct categories having scores from 0 (no fiscal vulnerability) to 4 (extreme fiscal vulnerability). Using annual data ranging over 1990–2013 for 28 European Union countries, we evidenced 310 episodes of fiscal vulnerability, out of which 128 episodes of low vulnerability, 94 of moderate, 62 of strong, and 26 of extreme fiscal vulnerability. We also found that over 2004–2013, Greece, Portugal, Romania, United Kingdom, Ireland, Spain, and Slovenia were the most fiscally vulnerable countries in the Union. United Kingdom and Greece went through the longest episodes of fiscal vulnerability, counting 12 and 11 consecutive years, respectively. We tested our framework’s effectiveness against the Excessive Deficit Procedure. We found that the overall performance is good: V-L-D assessed moderate fiscal vulnerability during the procedure, strong fiscal vulnerability in the first year when procedure was initiated, and extreme vulnerability one year before the initiation.

Clinical Experiences with Performing Laparoscopic Radical Nephrectomy after a One-year Educational Program

2008 ◽  
Vol 49 (9) ◽  
pp. 786
Author(s):  
Seung Hyun Jeon ◽  
Ill Young Seo ◽  
Jae-Sung Lim ◽  
Ryohei Hattori ◽  
Momokazu Gotoh ◽  
...  
Keyword(s):  
Radical Nephrectomy ◽  
Educational Program ◽  
Clinical Experiences ◽  
Laparoscopic Radical Nephrectomy ◽  
One Year

History of Life Assurance in the United Kingdom (Continued)

1886 ◽  
Vol 26 (1) ◽  
pp. 1-24
Author(s):  
Cornelius Walford
Keyword(s):  
Eighteenth Century ◽  
United Kingdom ◽  
Life Assurance ◽  
Important Principle ◽  
The United Kingdom ◽  
History Of ◽  
The Law ◽  
One Year

A case arose about this time—the middle of the eighteenth century—which, as it illustrated some points in practice and an important principle in the law of Insurance, I will briefly review. It is the case of Cleeve v. Gascoigne. In June 1749, the defendant (Gascoigne) had applied to an Office-keeper, or Broker, to insure £1,600 for one year at 5 per-cent on the life of one Poulton, from whom the defendant had agreed to purchase an estate, whereof Poulton had the reversion in fee, and also an intervening interest for his own life.

scholarly journals P09.44 One year with Optune in Austria: First report on clinical experiences

2017 ◽  
Vol 19 (suppl_3) ◽  
pp. iii80-iii80
Author(s):  
D. Pinggera ◽  
J. Kerschbaumer
Keyword(s):  
Clinical Experiences ◽  
First Report ◽  
One Year

scholarly journals An interactive COVID-19 virus Mutation Tracker (CovMT) with a particular focus on critical mutations in the Receptor Binding Domain (RBD) region of the Spike protein

2021 ◽  
Author(s):  
Intikhab Alam ◽  
Aleksandar Radovanovic ◽  
Roberto Incitti ◽  
Allan Kamau ◽  
Muhammad Alarawi ◽  
...  
Keyword(s):  
United Kingdom ◽  
Receptor Binding ◽  
Treatment Strategies ◽  
Binding Domain ◽  
Spike Protein ◽  
Receptor Binding Domain ◽  
Link Type ◽  
The United Kingdom ◽  
Public Resources ◽  
One Year

AbstractAlmost one year has passed since the appearance of SARS-CoV-2, causing the COVID-19 pandemic. The number of confirmed SARS-Cov-2 cases worldwide has now reached ∼92 million, with 2 million reported deaths (https://covid19.who.int). Nearly 400,000 SARS-Cov-2 genomes were sequenced from COVID-19 samples and added to public resources such as GISAID (https://gisaid.org). With the vaccines becoming available or entering trials (https://covid19.trackvaccines.org), it is vital to keep track of mutations in the genome of SARS-CoV-2, especially in the Spike protein’s Receptor Binding Domain (RBD) region, which could have a potential impact on disease severity and treatment strategies.1–3 In the wake of a recent increase in cases with a potentially more infective RBD mutation (N501Y) in the United Kingdom, countries worldwide are concerned about the spread of this or similar variants. Impressive sampling and timely increase in sequencing efforts related to COVID-19 in the United Kingdom (UK) helped detect and monitor the spread of the new N501Y variant. Similar sequencing efforts are needed in other countries for timely tracking of this or different variants. To track geographic sequencing efforts and mutations, with a particular focus on RBD region of the Spike protein, we present our daily updated COVID-19 virus Mutation Tracker system, see https://www.cbrc.kaust.edu.sa/covmt.

scholarly journals RARE-44. ONE YEAR WITH OPTUNE® IN ROUTINE USE: FIRST REPORT ON CLINICAL EXPERIENCES IN GERMANY

2016 ◽  
Vol 18 (suppl_6) ◽  
pp. vi169-vi169
Author(s):  
Martin Misch ◽  
Julia Onken
Keyword(s):  
Clinical Experiences ◽  
First Report ◽  
One Year

Marijuana Use and Sickle Cell Disease

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 4826-4826 ◽  
Author(s):  
Vladimir K. Gotlieb ◽  
Khine Z. Oo
Keyword(s):  
United Kingdom ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Hospital Admissions ◽  
Pain Syndrome ◽  
Marijuana Use ◽  
Clinical Severity ◽  
Cell Disease ◽  
Severe Nausea ◽  
One Year

Abstract A 45-year old Jamaican man with sickle cell disease came to our clinic complaining of chronic left ankle ulcer for one year. He stated that when he was a young boy he had had several hospital admissions for sickle cell crisis, usually precipitated by physical activity or infection, once or twice per month. We were surprised to find out that he had never had a crisis since the age of fifteen. We doubted his diagnosis yet his hemoglobin electrophoresis revealed HbS was 94.7%, HbF was 0.6% and HbA2 was 4.7%. He denied taking any medication. However, he admitted smoking 4 to 5 cigarettes of marijuana a day for the past 30 years. Cannabis has been used as a medicine even before the Christian era in Asia, first in China then mainly in India. Its use was later spread to the West. The general indications for marijuana were reported as severe nausea and vomiting, weight loss associated with debilitating illnesses, spasticity, pain syndrome, and glaucoma. Numerous Phase I–III studies in 2000 subjects with exposure of Sativex by GW Pharmaceuticals from United Kingdom demonstrated that the patients attained good sleep quality, which may improve patients’ quality of life in disabling chronic pain syndromes. We reviewed the literature on any report that cannabinoids could change the severity of sickle cell disease. We found the study from West Indies, which investigated the perception that marijuana use ameliorated the complications of sickle cell disease, in year 2000 and 2004. The study concluded that marijuana smoking is common in adults with sickle cell disease but its usage is unrelated to clinical severity of the disease. We also found a report, from Central Middlesex Hospital in London, United Kingdom, which observed 86 young adults with HbSS, HbSC and HbSbetathalassemia disease, median age being 30 years. Results of this study showed that 31 (36%) had used cannabis in the previous 12 months to relieve the symptoms associated with sickle cell disease. Symptoms related to sedation and mood effects were reported in 77% of patients. The main reasons for use of cannabis were to reduce pain in 52% and to induce relaxation or relieve anxiety and depression in 39%. (5) We wondered if any physicians had observed similar effects of marijuana in sickle cell disease patients in their practice. Could ‘Marijuana Use has beneficial effect on Sickle Cell Disease’ be an interesting topic for a broader clinical trial or a retrospective analysis?

Blood groups in dementia (SDAT) — a pilot study

1993 ◽  
Vol 10 (2) ◽  
pp. 96-97
Author(s):  
V M Mathew
Keyword(s):  
United Kingdom ◽  
Pilot Study ◽  
Senile Dementia ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
United Kingdom Population ◽  
Dementia Of Alzheimer’S Type ◽  
Group A ◽  
One Year ◽  
Group B

AbstractObjective:Various studies have shown an association between ABO blood groups and both physical and mental illness. This pilot study was conducted to find out whether there is any association between ABO blood groups and senile dementia of Alzheimer's type.Methods:The sample was selected from 107 patients admitted to the psychogeriatric assessment unit of the district psychiatric hospital over a period of one year. All Caucasian patients of United Kingdom origin above the age of 70 with confirmed diagnosis of Alzheimer's dementia according to DSM-III criteria who had developed dementia after the age of 65 were included (N = 33); 74 patients were excluded for various reasons.Results:Out of the 33 patients there were 21 (64%) with group A, 3 (9%) with group B, 9 (27%) with group O and none with group AB blood. Among the United Kingdom population there were 79,334 (42%) with group A, 16,280 (9%) with group B, 88,782 (47%) with group O and 5,781 (3%) with group AB blood (p = 0.038).Conclusions:Although the number of cases were not large, the results of this study suggest that the prevalence of type A blood group was greater and O was less for Caucasian Alzheimer's subjects than for the general population.

Factors influencing the rate of incidents in a United Kingdom high secure psychiatric hospital: Weekend, ward round and diagnostic effect?

2017 ◽  
Vol 41 (S1) ◽  
pp. S353-S354
Author(s):  
F. Lewis ◽  
H. Blott ◽  
S. Bhattacherjee
Keyword(s):  
Mental Illness ◽  
United Kingdom ◽  
Personality Disorder ◽  
Psychiatric Hospital ◽  
Ward Round ◽  
Factors Influencing ◽  
Incident Reports ◽  
The Difference ◽  
Competing Interest ◽  
One Year

IntroductionBroadmoor is a high secure psychiatric hospital divided into personality disorder (PD) and mental illness (MI) pathways. Whenever an incident occurs, it should be recorded. To better understand which factors influence the rate of incidents, such as diagnosis or intervention by medical and psychological staff, we examined the difference in the number of incidents recorded on weekdays versus weekends, ward round (WR) versus non-WR days and the PD versus MI pathways.MethodAll incidents recorded over a one-year period (3.11.2014–2.11.2015) were examined. Extraneous incidents were excluded, leaving subgroups of “aggressive” (physical and verbal) and “physical” (excluding verbal) incidents which were analysed. Data were adjusted for the difference in number of beds in each pathway.ResultsOf the 2369 incident reports included, more were recorded per day on weekdays than weekends, with little difference on WR versus non-WR days. The rates of both types of incidents were similar on both PD and MI admission wards, although the rate of “physical” incidents was 2.6 times higher and “aggressive” incidents 3.3 times higher in PD compared to MI rehabilitation wards.ConclusionThe findings suggest the presence of medical and psychological staff during the week, and possibly the requirements they place on patients, may increase the rate of incidents within the hospital. Despite comparable rates on admission, MI rehabilitation wards have far fewer incidents than PD rehab wards, which may reflect the more intractable nature of PD versus MI. More work is required to confirm these findings.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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