Retinol-binding protein 4 as a biomarker of cardiometabolic risk in rheumatoid arthritis

2020 ◽  
Vol 4 (2) ◽  
pp. 106
Author(s):  
RadwaM Fath Allah ◽  
KhalidaE El-Refaei ◽  
EnayatE Osman ◽  
Seham Sabry ◽  
ImanM Elbagoury
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiometabolic Risk ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4

Serum retinol-binding protein 4 is associated with insulin resistance in patients with early and untreated rheumatoid arthritis

2019 ◽  
Vol 86 (3) ◽  
pp. 335-341 ◽  
Author(s):  
Yanlin Wei ◽  
Nannan Xia ◽  
Weifeng Zhang ◽  
Jiashu Huang ◽  
Zhijuan Ren ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Insulin Resistance ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Serum Retinol ◽  
Retinol Binding Protein 4

scholarly journals The Relationship of Retinol Binding Protein 4 to Changes in Insulin Resistance and Cardiometabolic Risk in Overweight Black Adolescents

2009 ◽  
Vol 154 (1) ◽  
pp. 67-73.e1 ◽  
Author(s):  
Elizabeth Goodman ◽  
Timothy E. Graham ◽  
Lawrence M. Dolan ◽  
Stephen R. Daniels ◽  
Eric R. Goodman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cardiometabolic Risk ◽  
Black Adolescents ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4 ◽  
Relationship Of ◽  
The Relationship

The Association between Cardiometabolic Risk Clustering, Retinol-binding Protein 4 and Adolescent Insulin Resistance

2017 ◽  
Vol 27 (8) ◽  
pp. 511
Author(s):  
Pei-Chen Lin ◽  
Wei-Ting Lin ◽  
Yi-Ling Chen ◽  
Te-Fu Chan ◽  
Chun-Ying Lee ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cardiometabolic Risk ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4

THU0065 Role of retinol binding protein 4 in insulin resistance of rheumatoid arthritis patients

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 174.3-175
Author(s):  
M. Flores-Rodríguez ◽  
I. Ferraz-Amaro ◽  
V. Hernández-Hernández ◽  
J. Viotti ◽  
C. Rodríguez de la Rosa ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Insulin Resistance ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4

scholarly journals Retinol Binding Protein 4 Concentrations Relate to Enhanced Atherosclerosis in Obese Patients with Rheumatoid Arthritis

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e92739 ◽  
Author(s):  
Patrick H. Dessein ◽  
Linda Tsang ◽  
Gavin R. Norton ◽  
Angela J. Woodiwiss ◽  
Ahmed Solomon
Keyword(s):  
Rheumatoid Arthritis ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Obese Patients ◽  
Retinol Binding Protein 4

Retinol-binding Protein 4 in Rheumatoid Arthritis-related Insulin Resistance and β-cell Function

2014 ◽  
Vol 41 (4) ◽  
pp. 658-665 ◽  
Author(s):  
Iván Ferraz-Amaro ◽  
Miguel A. González-Gay ◽  
Federico Diaz-González
Keyword(s):  
Rheumatoid Arthritis ◽  
Insulin Resistance ◽  
Cell Function ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Β Cell ◽  
C Peptide ◽  
Retinol Binding Protein 4 ◽  
Significant Difference ◽  
Β Cell Function

Objective.Retinol-binding protein 4 (RBP4), an adipokine related to impaired glucose tolerance, has been associated with insulin resistance (IR) and β-cell function in subjects with obesity or diabetes. In our study we assessed RBP4 levels in patients with rheumatoid arthritis (RA). We also determined whether any correlation exists between RBP4 levels and the presence of IR in these patients.Methods.Plasma RBP4, insulin, C-peptide concentrations, and homeostasis model assessment (HOMA)-IR were measured in 101 patients with RA and 115 sex-matched and age-matched controls. A multivariable analysis adjusted for IR classic cardiovascular risk factors and body mass index was performed to establish the correlation between RBP4 plasma concentrations and features of IR in RA. Data were adjusted for glucocorticoid intake in patients with RA.Results.Patients had higher levels of insulin, C-peptide levels, HOMA-percentage of β-cell secretion (%B) index, and HOMA-IR index than controls. RBP4 levels were significantly lower in the whole group of patients than in controls [13.99 (9.78–19.88) vs 21.50 (10.28–32.59) μg/ml, p < 0.01]. However, only those who were glucocorticoid-naive showed significant difference in RBP4 plasma concentration when compared to controls [11.88 (7.93–17.96) vs 21.50 (10.28–32.59) μg/ml, p < 0.01]. The HOMA-%B [log β coefficient 0.00 (0.00–0.01), p < 0.01] showed positive relationships regarding RBP4 in controls. That was not the case in patients with RA [log β coefficient 0.00 (−0.0–0.00), p = 0.93 for HOMA-%B].Conclusion.RBP4 does not correlate with the presence of IR and β-cell function in patients with RA. The mechanisms leading to IR in RA may be different from those occurring in obesity or diabetes.

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