scholarly journals Pharmacotherapy of Bipolar I Disorder: Focus on Aripiprazole

2009 ◽  
Vol 1 ◽  
pp. CMT.S2238
Author(s):  
Leo Bastiaens
Keyword(s):  
Bipolar Disorder ◽  
Treatment Options ◽  
Borderline Personality ◽  
Tolerability Profile ◽  
Metabolic Disturbances ◽  
Good Tolerability ◽  
Hyperactivity Disorder ◽  
Good Tolerability Profile ◽  
Co Morbidity ◽  
Chronic Course

Bipolar disorder is a common and complex condition, starting early in life and continuing throughout the life cycle. Most people suffering from bipolar disorder manifest other problems as well, including metabolic disturbances, cardiovascular disease, anxiety disorders, substance use disorders, attention deficit hyperactivity disorder, and borderline personality disorder, among others. The treatment of bipolar disorder needs to be conceptualized within this context of early onset, chronic course, and significant co-morbidity. Because of its unique mode of action, its efficacy and its good tolerability profile, aripiprazole is well placed among the different treatment options to benefit the patient with bipolar disorder. This article will focus on aripiprazole's pharmacology, efficacy, effectiveness, and tolerability from a clinical perspective, while considering the complexities of bipolar disorder.

Bipolar disorder co-morbidity in children with attention deficit hyperactivity disorder

2011 ◽  
Vol 186 (2-3) ◽  
pp. 333-337 ◽  
Author(s):  
Renato Donfrancesco ◽  
Silvia Miano ◽  
Francesca Martines ◽  
Laura Ferrante ◽  
Maria Grazia Melegari ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Hyperactivity Disorder ◽  
Co Morbidity

Gender differences in dual bipolar disorder

2017 ◽  
Vol 41 (S1) ◽  
pp. S477-S478
Author(s):  
G. Mateu-Codina ◽  
R. Sauras-Quetcuti ◽  
A. Farre-Martinez ◽  
L. Galindo-Guarín ◽  
J. Marti-Bonany ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Borderline Personality ◽  
Dually Diagnosed ◽  
Sociodemographic Differences ◽  
Co Morbidity ◽  
Severity Scores ◽  
Substance Abuse Disorders ◽  
Dsm Iv ◽  
Competing Interest ◽  
Image Position

IntroductionWomen with bipolar disorder are more prone to psychiatric co-morbidity as anxiety, substance use disorders, eating disorders and borderline personality disorder. Nevertheless, substance abuse disorders as co-morbidity in bipolarity are higher in males than females.ObjectivesTo describe differential characteristics of patients admitted to a psychiatric unit referring to gender in a group of patients with bipolar disorder co-morbid with substances disorders (dually diagnosed patients).MethodsSociodemographic, clinical and administrative data of all patients diagnosed with bipolar admitted to a dual diagnosis during a 3-year period were collected. The psychiatric diagnosis was made according to DSM-IV-R criteria.ResultsFrom the whole sample (n = 66), males (84.8%) were prevalent. Mean age were 37.71 ± 11.7 and mean length of admission was 24.94 ± 17.9 days. Cannabis (34.8%) and cocaine (33.3%) were the most frequent SUD diagnosis and main reasons for admittance were conduct disorder (33.3%) and mania (25.8%).Women showed higher length of admission, higher severity scores at admission and greater reduction in severity scores along hospitalisation. No other clinical or sociodemographic differences were found comparing both groups of patients (Tables 1–4).ConclusionsWomen affected by dual bipolar disorder showed higher severity scores at admission but achieved better remission rates during hospitalisation.Table 1Demographic characteristics of both groups.Table 2Clinical and functional variables at admission in both groups.Table 3Historical data about age of drug use in both groups.Table 4Severity Scores for both groups of study.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Gender Difference Among Admitted Patients with Bipolar Disorder in a Psychiatric Service During a Three-year Period

2017 ◽  
Vol 41 (S1) ◽  
pp. S115-S115
Author(s):  
M. Fernandes ◽  
D. Mota ◽  
A. Olivera ◽  
J. Ribeiro ◽  
S. Silva ◽  
...  
Keyword(s):  
Gender Differences ◽  
Bipolar Disorder ◽  
Suicide Attempts ◽  
Psychiatric Service ◽  
Treatment Options ◽  
Age At Onset ◽  
Men And Women ◽  
Course Of Illness ◽  
Co Morbidity ◽  
Significant Difference

IntroductionGender differences in bipolar disorder are becoming apparent, but have been less studied compared with major depression. The presentation, clinical features, course and evolution of bipolar disorder differ between men and women. Research data on these differences will help determine whether gender is important in influencing illness variables.ObjectivesDetermine whether men and women with bipolar disorder have statistical significant differences in socio-demographic and clinical data.MethodsCharts of all patients with a diagnosis of bipolar disorder admitted in the Coimbra Hospital and Universitary Center over a three-year period (between 2013 and 2015) were reviewed to gather data on socio-demographic, clinical and psychopathological variables to assess differences across genders. Statistical analysis of data with “SPSS21”.ResultsDuring a three-year period, 189 patients were admitted with bipolar disorder, the majority were female patients, with ages between 21 and 84 years old. The authors will analyse if there is any statistical significant difference between gender in the rate of bipolar I or II diagnoses, age at onset, symptom presentation, delay in diagnoses, number of depressive, or manic episodes, hospitalisations, involuntarily admissions, number of suicide attempts, co-morbidity rates, negative life events, family history and treatment options. Sociodemograpic characteristics will also be analysed.ConclusionGender differences in bipolar disorder is a controversial issue in the literature. The importance of gender on the course and outcome in bipolar disorder has been widely acknowledged. The limited data suggest that the prevalence is similar between sexes but that the course of illness may be different.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Towards further understanding of the co-morbidity between attention deficit hyperactivity disorder and bipolar disorder: a MRI study of brain volumes

2007 ◽  
Vol 38 (7) ◽  
pp. 1045-1056 ◽  
Author(s):  
J. Biederman ◽  
N. Makris ◽  
E. M. Valera ◽  
M. C. Monuteaux ◽  
J. M. Goldstein ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Attention Deficit Hyperactivity Disorder ◽  
Prefrontal Cortex ◽  
Gray Matter ◽  
Attention Deficit ◽  
Anterior Cingulate ◽  
Mri Findings ◽  
Brain Volumes ◽  
Hyperactivity Disorder ◽  
Co Morbidity

BackgroundAlthough attention deficit hyperactivity disorder (ADHD) and bipolar disorder (BPD) co-occur frequently and represent a particularly morbid clinical form of both disorders, neuroimaging research addressing this co-morbidity is scarce. Our aim was to evaluate the morphometric magnetic resonance imaging (MRI) underpinnings of the co-morbidity of ADHD with BPD, testing the hypothesis that subjects with this co-morbidity would have neuroanatomical correlates of both disorders.MethodMorphometric MRI findings were compared between 31 adults with ADHD and BPD and with those of 18 with BPD, 26 with ADHD, and 23 healthy controls. The volumes (cm3) of our regions of interest (ROIs) were estimated as a function of ADHD status, BPD status, age, sex, and omnibus brain volume using linear regression models.ResultsWhen BPD was associated with a significantly smaller orbital prefrontal cortex and larger right thalamus, this pattern was found in co-morbid subjects with ADHD plus BPD. Likewise, when ADHD was associated with significantly less neocortical gray matter, less overall frontal lobe and superior prefrontal cortex volumes, a smaller right anterior cingulate cortex and less cerebellar gray matter, so did co-morbid ADHD plus BPD subjects.ConclusionsOur results support the hypothesis that ADHD and BPD independently contribute to volumetric alterations of selective and distinct brain structures. In the co-morbid state of ADHD plus BPD, the profile of brain volumetric abnormalities consists of structures that are altered in both disorders individually. Attention to co-morbidity is necessary to help clarify the heterogeneous neuroanatomy of both BPD and ADHD.

The impact of psychiatric co-morbidity in the treatment of bipolar disorder: focus on co-occurring attention deficit hyperactivity disorder and eating disorders

2017 ◽  
Author(s):  
Anna I. Guerdjikova ◽  
Paul E. Keck ◽  
Susan L. McElroy
Keyword(s):  
Bipolar Disorder ◽  
Attention Deficit Hyperactivity Disorder ◽  
Eating Disorders ◽  
Attention Deficit ◽  
Case Reports ◽  
Open Label ◽  
Hyperactivity Disorder ◽  
Randomized Controlled ◽  
Co Morbidity ◽  
The Impact

Bipolar disorder (BD) commonly co-occurs with attention deficit hyperactivity disorder (ADHD) and eating disorders (EDs) in adolescents and in adults. The aim of this chapter is to summarize the available data regarding prevalence, clinical presentation, and psychological and pharmacological treatment of such complicated cases. Results of randomized controlled and open-label trials and case reports are reviewed. The main therapeutic goal when treating BD co-morbid with ADHD or ED is selecting a treatment strategy effective in the management of both syndromes, or at the minimum, selecting one that treats one syndrome without exacerbating the other. Controlled data are scarce. Various classes of medications, including stimulants, atomoxetine, bupropion, and wakefulness-provoking agents, might hold promise as adjunctive medication in improving ADHD symptoms in euthymic BD patients. The specificities of the ED, namely the predominance of undereating or overeating, need to be considered when selecting agents in the treatment of BD co-morbid with EDs.

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